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glpE glpE plu0298 plu0298 plu0523 plu0523 plu0524 plu0524 serB serB cysJ cysJ cysI cysI cysH cysH cysD cysD cysN cysN cysC cysC plu1004 plu1004 pepD pepD gshA gshA cysP cysP cysT cysT cysW cysW cysA cysA cysM cysM cysK cysK sseA sseA pepN pepN dsdA dsdA plu2021 plu2021 plu2684 plu2684 sdaA sdaA pepB pepB plu3517 plu3517 metK metK plu3731 plu3731 cysS cysS plu3861 plu3861 metC metC tyrB tyrB metA metA metE metE pepA pepA cysQ cysQ plu4568 plu4568 ilvA ilvA metB metB sbp sbp cysE cysE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glpEThiosulfate sulfurtransferase GlpE; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (111 aa)
plu0298Unnamed protein product; Some similarities with the N-terminal region of cysteine synthase A. (109 aa)
plu0523Unnamed protein product; Similar to cystathionine gamma-lyase. (384 aa)
plu0524Unnamed protein product; Similar to cystathionine beta-synthase. (455 aa)
serBPhosphoserine phosphatase. (325 aa)
cysJSulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (600 aa)
cysISulfite reductase [NADPH] hemoprotein beta-component (SIR-HP); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (576 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
cysDSulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). (302 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (461 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (210 aa)
plu1004TauD domain-containing protein; Unnamed protein product; Similar to alpha-ketoglutarate-dependent taurine dioxygenase (2-aminoethanesulfonate dioxygenase). (315 aa)
pepDAminoacyl-histidine dipeptidase (XAA-His dipeptidase) (beta-alanyl-histidine dipeptidase) (carnosinase) (peptidase D). (486 aa)
gshAGlutamate--cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (519 aa)
cysPThiosulfate-binding protein precursor cysP. (340 aa)
cysTSulfate transport system permease protein cysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
cysWSulfate transport system permease protein cysW. (281 aa)
cysASulfate transport ATP-binding protein cysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (362 aa)
cysMCysteine synthase B (O-acetylserine sulfhydrolase B); Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa)
cysKCysteine synthase A (O-acetylserine sulfhydrolase A); Belongs to the cysteine synthase/cystathionine beta- synthase family. (317 aa)
sseASulfurtransferase; Truncated gene. Similar to N-terminal region of transposase. (278 aa)
pepNAminopeptidase N. (870 aa)
dsdAD-serine dehydratase DsdA. (443 aa)
plu2021Serine acetyltransferase; Unnamed protein product; Some similarities with serine O-acetyltransferase. (198 aa)
plu2684GAF domain-containing protein; Unnamed protein product; Similar to probable membrane protein YebR of Escherichia coli. (165 aa)
sdaAL-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
pepBPeptidase B (Aminopeptidase B); Probably plays an important role in intracellular peptide degradation. (431 aa)
plu3517Unnamed protein product; Highly similar to homocysteine synthase. (424 aa)
metKS-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (390 aa)
plu3731Aminotran_1_2 domain-containing protein; Unnamed protein product; Similar to aminotransferases. (392 aa)
cysScysteinyl-tRNA synthetase (cysteine--tRNA ligase) (CysRS); Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
plu3861PALP domain-containing protein; Unnamed protein product; Similar to cysteine synthase. (350 aa)
metCCystathionine beta-lyase (CHL) (beta-cystathionase) (cysteine lyase). (396 aa)
tyrBAromatic-amino-acid aminotransferase (AROAT) (ARAT). (399 aa)
metAHomoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
metE5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa)
pepACytosol aminopeptidase (leucine aminopeptidase) (LAP) (leucyl aminopeptidase) (aminopeptidase A/I); Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (506 aa)
cysQCysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (247 aa)
plu4568PALP domain-containing protein; Unnamed protein product; Similar to cystathionine beta-synthase (cysteine synthase). (342 aa)
ilvAThreonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (519 aa)
metBCystathionine gamma-synthase (CGS) (O-succinylhomoserine (Thiol)-lyase). (390 aa)
sbpSulfate-binding protein precursor (sulfate starvation-induced protein 2) (SSI2). (331 aa)
cysESerine acetyltransferase (SAT). (273 aa)
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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