(5 nodes) beta-Lactam resistance, and Antibiotic resistance network (Psychrobacter arcticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Your Input:
	macB	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (665 aa)
	Psyc_1575	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (448 aa)
	acrB	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30. (1075 aa)
	oprM	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27. (606 aa)
	Psyc_1819	Hypothetical protein. (372 aa)

Your Current Organism:

Psychrobacter arcticus

NCBI taxonomy Id: 259536
Other names: P. arcticus 273-4, Psychrobacter arcticus 273-4, Psychrobacter arcticus str. 273-4, Psychrobacter arcticus strain 273-4, Psychrobacter sp. 273-4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Psyc_1575	acrB	Psyc_1575	Psyc_1576	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	0.999
Psyc_1575	macB	Psyc_1575	Psyc_0572	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.994
Psyc_1575	oprM	Psyc_1575	Psyc_1577	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	0.997
Psyc_1819	acrB	Psyc_1819	Psyc_1576	Hypothetical protein.	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	0.523
Psyc_1819	macB	Psyc_1819	Psyc_0572	Hypothetical protein.	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.993
Psyc_1819	oprM	Psyc_1819	Psyc_1577	Hypothetical protein.	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	0.581
acrB	Psyc_1575	Psyc_1576	Psyc_1575	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.999
acrB	Psyc_1819	Psyc_1576	Psyc_1819	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	Hypothetical protein.	0.523
acrB	macB	Psyc_1576	Psyc_0572	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.547
acrB	oprM	Psyc_1576	Psyc_1577	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	0.999
macB	Psyc_1575	Psyc_0572	Psyc_1575	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.994
macB	Psyc_1819	Psyc_0572	Psyc_1819	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Hypothetical protein.	0.993
macB	acrB	Psyc_0572	Psyc_1576	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	0.547
macB	oprM	Psyc_0572	Psyc_1577	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	0.984
oprM	Psyc_1575	Psyc_1577	Psyc_1575	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	RND membrane fusion protein AcrA; Related to HlyD family; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.676 at residue 22; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.997
oprM	Psyc_1819	Psyc_1577	Psyc_1819	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	Hypothetical protein.	0.581
oprM	acrB	Psyc_1577	Psyc_1576	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	RND Superfmily multidrug/dye/detergent efflux pump AcrB; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.413 at residue 30.	0.999
oprM	macB	Psyc_1577	Psyc_0572	Outer membrane efflux protein, OprM; Signal predicted by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.740 at residue 27.	ABC macrolide efflux transporter MacB, fused ATPase and inner membrane domains; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.984

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