STRINGSTRING
SCF43173.1 SCF43173.1 SCF43539.1 SCF43539.1 SCF41034.1 SCF41034.1 SCF40894.1 SCF40894.1 SCF42084.1 SCF42084.1 SCE75750.1 SCE75750.1 add add SCE74621.1 SCE74621.1 SCE73441.1 SCE73441.1 SCE73326.1 SCE73326.1 SCE73246.1 SCE73246.1 SCE72648.1 SCE72648.1 purK purK purE purE SCE71023.1 SCE71023.1 SCE70444.1 SCE70444.1 SCE64193.1 SCE64193.1 SCE68745.1 SCE68745.1 SCF40769.1 SCF40769.1 SCF38329.1 SCF38329.1 SCF40047.1 SCF40047.1 SCF39973.1 SCF39973.1 SCF39968.1 SCF39968.1 nrdR nrdR SCF39663.1 SCF39663.1 SCF38760.1 SCF38760.1 rph rph SCE68497.1 SCE68497.1 SCE67071.1 SCE67071.1 SCE65948.1 SCE65948.1 SCE65913.1 SCE65913.1 SCE86965.1 SCE86965.1 SCE86948.1 SCE86948.1 SCE86649.1 SCE86649.1 SCE85774.1 SCE85774.1 purA purA purD purD SCE85428.1 SCE85428.1 purS purS purQ purQ purL purL purF purF purM purM guaA guaA purN purN purH purH SCF13950.1 SCF13950.1 ychF ychF SCF12827.1 SCF12827.1 SCF12814.1 SCF12814.1 purC purC SCF12163.1 SCF12163.1 SCF10279.1 SCF10279.1 SCF08759.1 SCF08759.1 SCF03276.1 SCF03276.1 SCF03258.1 SCF03258.1 SCF02387.1 SCF02387.1 SCF02369.1 SCF02369.1 SCF02349.1 SCF02349.1 SCF02313.1 SCF02313.1 SCF02294.1 SCF02294.1 SCF02279.1 SCF02279.1 SCF02264.1 SCF02264.1 SCF02246.1 SCF02246.1 SCE97339.1 SCE97339.1 SCE96821.1 SCE96821.1 SCE96806.1 SCE96806.1 SCE96225.1 SCE96225.1 SCE96188.1 SCE96188.1 SCE95909.1 SCE95909.1 SCE95378.1 SCE95378.1 SCE94202.1 SCE94202.1 SCE64846.1 SCE64846.1 SCE79458.1 SCE79458.1 SCE77057.1 SCE77057.1 SCE64644.1 SCE64644.1 prs prs SCE75809.1 SCE75809.1 SCF34500.1 SCF34500.1 SCF34289.1 SCF34289.1 SCF34278.1 SCF34278.1 SCF34159.1 SCF34159.1 SCF33912.1 SCF33912.1 SCF36981.1 SCF36981.1 SCF36728.1 SCF36728.1 SCF36501.1 SCF36501.1 SCF36162.1 SCF36162.1 SCF33791.1 SCF33791.1 SCF34864.1 SCF34864.1 tilS tilS SCF32755.1 SCF32755.1 cysN cysN SCF32154.1 SCF32154.1 SCF31511.1 SCF31511.1 apt apt SCF31013.1 SCF31013.1 SCF29558.1 SCF29558.1 SCF29315.1 SCF29315.1 SCF28620.1 SCF28620.1 SCF28424.1 SCF28424.1 SCF19090.1 SCF19090.1 SCF24934.1 SCF24934.1 SCF24054.1 SCF24054.1 adk adk truA truA guaB guaB SCF14937.1 SCF14937.1 SCE84684.1 SCE84684.1 SCE84664.1 SCE84664.1 SCE83967.1 SCE83967.1 SCE63874.1 SCE63874.1 ndk ndk SCF46719.1 SCF46719.1 SCF46431.1 SCF46431.1 SCF46380.1 SCF46380.1 SCF46371.1 SCF46371.1 SCF45967.1 SCF45967.1 SCF45378.1 SCF45378.1 SCF44938.1 SCF44938.1 SCF45174.1 SCF45174.1 SCF45151.1 SCF45151.1 SCF45542.1 SCF45542.1 SCF45421.1 SCF45421.1 SCF44634.1 SCF44634.1 SCF44539.1 SCF44539.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCF43173.1AAA ATPase domain-containing protein. (412 aa)
SCF43539.1Hypothetical protein. (294 aa)
SCF41034.1AAA ATPase domain-containing protein. (1121 aa)
SCF40894.1GTP pyrophosphokinase. (596 aa)
SCF42084.1Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
SCE75750.1Putative hemolysin. (346 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (358 aa)
SCE74621.1IMP dehydrogenase. (482 aa)
SCE73441.1XTP/dITP diphosphohydrolase. (331 aa)
SCE73326.1Hypothetical protein. (188 aa)
SCE73246.1Exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase. (314 aa)
SCE72648.1Histidine triad (HIT) family protein. (136 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (375 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa)
SCE71023.1Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (196 aa)
SCE70444.1Uncharacterized conserved protein, DUF427 family. (94 aa)
SCE64193.1Diadenosine tetraphosphate (Ap4A) hydrolase. (203 aa)
SCE68745.12-polyprenyl-6-methoxyphenol hydroxylase. (368 aa)
SCF40769.1Adenosine kinase. (325 aa)
SCF38329.1Hypothetical protein. (327 aa)
SCF40047.1Hypothetical protein. (262 aa)
SCF39973.1Hemolysin, contains CBS domains. (450 aa)
SCF39968.1Hemolysin, contains CBS domains. (354 aa)
nrdRTranscriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (177 aa)
SCF39663.1Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (960 aa)
SCF38760.1ACT domain. (233 aa)
rphRNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (242 aa)
SCE68497.1XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (206 aa)
SCE67071.1Electron transfer flavoprotein beta subunit. (259 aa)
SCE65948.1DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (225 aa)
SCE65913.1CHAD domain-containing protein. (504 aa)
SCE86965.1Hemolysin, contains CBS domains. (435 aa)
SCE86948.1Hemolysin, contains CBS domains. (333 aa)
SCE86649.1Adenine phosphoribosyltransferase. (183 aa)
SCE85774.1Hypothetical protein. (403 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (415 aa)
SCE85428.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (473 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (87 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (227 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (945 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (513 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (384 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (518 aa)
purNPhosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (523 aa)
SCF13950.1Adenylylsulfate kinase. (509 aa)
ychFHypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (361 aa)
SCF12827.1Hypothetical protein. (325 aa)
SCF12814.1Hypothetical protein; Belongs to the LOG family. (181 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (266 aa)
SCF12163.1Ribose-phosphate pyrophosphokinase. (312 aa)
SCF10279.1Predicted kinase. (298 aa)
SCF08759.1Predicted phosphoesterase. (241 aa)
SCF03276.1Hypothetical protein. (145 aa)
SCF03258.1Histidine triad (HIT) family protein. (146 aa)
SCF02387.15-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (108 aa)
SCF02369.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. (138 aa)
SCF02349.1Guanine deaminase. (475 aa)
SCF02313.1Xanthine dehydrogenase, molybdenum binding subunit apoprotein. (809 aa)
SCF02294.1Xanthine dehydrogenase small subunit. (542 aa)
SCF02279.1Allantoinase. (445 aa)
SCF02264.1Urate oxidase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (301 aa)
SCF02246.1Hypothetical protein; Belongs to the LOG family. (211 aa)
SCE97339.1HD domain-containing protein. (239 aa)
SCE96821.1AAA ATPase domain-containing protein. (677 aa)
SCE96806.1Predicted ATPase. (975 aa)
SCE96225.1Hypothetical protein. (163 aa)
SCE96188.1Hypothetical protein. (137 aa)
SCE95909.13',5'-cyclic AMP phosphodiesterase CpdA. (294 aa)
SCE95378.1tRNA(Arg) A34 adenosine deaminase TadA. (144 aa)
SCE94202.1DNA-binding transcriptional activator of the SARP family. (1109 aa)
SCE64846.1Hypothetical protein. (167 aa)
SCE79458.1Predicted PurR-regulated permease PerM. (374 aa)
SCE77057.1Mg/Co/Ni transporter MgtE (contains CBS domain). (428 aa)
SCE64644.1F5/8 type C domain-containing protein. (504 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
SCE75809.1Sulfate adenylyltransferase subunit 2. (303 aa)
SCF34500.1AAA ATPase domain-containing protein. (1206 aa)
SCF34289.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (579 aa)
SCF34278.1Calcineurin-like phosphoesterase. (96 aa)
SCF34159.1Protein of unknown function (DUF1524). (200 aa)
SCF33912.1NUDIX domain-containing protein; Belongs to the Nudix hydrolase family. (224 aa)
SCF36981.1Hypothetical protein. (1088 aa)
SCF36728.1Ppx/GppA phosphatase. (314 aa)
SCF36501.1O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain. (171 aa)
SCF36162.1Predicted PurR-regulated permease PerM. (432 aa)
SCF33791.1Purine-nucleoside phosphorylase. (235 aa)
SCF34864.1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (191 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (327 aa)
SCF32755.1Putative hemolysin. (442 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (435 aa)
SCF32154.1Guanylate kinase. (151 aa)
SCF31511.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (826 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (201 aa)
SCF31013.1Diadenosine tetraphosphate (Ap4A) hydrolase. (181 aa)
SCF29558.1dGTPase; Belongs to the dGTPase family. Type 2 subfamily. (503 aa)
SCF29315.1Phosphoglucomutase. (547 aa)
SCF28620.1Uncharacterized conserved protein, DUF427 family. (153 aa)
SCF28424.1YjbR. (113 aa)
SCF19090.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (596 aa)
SCF24934.1Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (401 aa)
SCF24054.1Predicted PurR-regulated permease PerM. (372 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
truAtRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (277 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (520 aa)
SCF14937.1IMP dehydrogenase. (372 aa)
SCE84684.1Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (333 aa)
SCE84664.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (770 aa)
SCE83967.1Lamin Tail Domain. (151 aa)
SCE63874.1Adenylate kinase. (174 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
SCF46719.1Putative hydrolase of the HAD superfamily. (214 aa)
SCF46431.1Regulatory protein, luxR family. (1009 aa)
SCF46380.1GMP synthase-Glutamine amidotransferase. (273 aa)
SCF46371.1Calcineurin-like phosphoesterase. (515 aa)
SCF45967.1ADP-ribose pyrophosphatase. (201 aa)
SCF45378.1dGTPase; Belongs to the dGTPase family. Type 2 subfamily. (426 aa)
SCF44938.1EDD domain protein, DegV family. (281 aa)
SCF45174.1Hemolysin, contains CBS domains. (463 aa)
SCF45151.1Histidine triad (HIT) family protein. (116 aa)
SCF45542.1Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily. (464 aa)
SCF45421.1Hypothetical protein. (178 aa)
SCF44634.1Hypothetical protein. (345 aa)
SCF44539.1Zn-dependent protease (includes SpoIVFB); Belongs to the peptidase M50B family. (383 aa)
Your Current Organism:
Micromonospora mirobrigensis
NCBI taxonomy Id: 262898
Other names: DSM 44830, JCM 13240, LMG 22229, LMG:22229, M. mirobrigensis, Micromonospora mirobrigensis Trujillo et al. 2005, Micromonospora sp. WA201, NBRC 101890, strain WA201
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