STRINGSTRING
PRU_0373 PRU_0373 purU purU glyA glyA hprA hprA PRU_0872 PRU_0872 PRU_1230 PRU_1230 PRU_1370 PRU_1370 glnA_1 glnA_1 mutB mutB mutA mutA PRU_1696 PRU_1696 glnA_2 glnA_2 PRU_2044 PRU_2044 gcvP2 gcvP2 gcvP1 gcvP1 gcvH gcvH gcvT gcvT PRU_2071 PRU_2071 PRU_2158 PRU_2158 PRU_2205 PRU_2205
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRU_0373Haloacid dehalogenase-like hydrolase domain protein; Identified by match to protein family HMM PF00702. (198 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
hprAGlycerate dehydrogenase (NADH-dependent); Identified by similarity to SP:Q59516; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (299 aa)
PRU_0872Putative 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase; Identified by similarity to SP:P10177; match to protein family HMM PF01081. (216 aa)
PRU_1230Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081. (136 aa)
PRU_1370HAD-superfamily hydrolase, subfamily IA, variant 3; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. (213 aa)
glnA_1Glutamine synthetase, type III; Identified by similarity to GB:AAF91344.1; match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (730 aa)
mutBmethylmalonyl-CoA mutase, large subunit; Identified by similarity to SP:Q05065; match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641. (721 aa)
mutAmethylmalonyl-CoA mutase, small subunit; Identified by match to protein family HMM PF01642; match to protein family HMM TIGR00642. (620 aa)
PRU_1696Identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; Belongs to the glycerate kinase type-1 family. (354 aa)
glnA_2Glutamine synthetase, type III; Identified by similarity to GB:AAF91344.1; match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (737 aa)
PRU_2044Dihydrolipoyl dehydrogenase; Identified by similarity to GB:AAA21748.1; match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF07992; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (428 aa)
gcvP2Glycine dehydrogenase (decarboxylating), subunit 2; Identified by similarity to SP:Q8RCW2. (469 aa)
gcvP1Glycine dehydrogenase (decarboxylating), subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (438 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
PRU_2071Putative glutamine synthetase; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (501 aa)
PRU_2158Putative malate dehydrogenase; Identified by similarity to SP:P10584; match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily. (328 aa)
PRU_2205AMP-binding enzyme; Identified by match to protein family HMM PF00501. (550 aa)
Your Current Organism:
Prevotella ruminicola
NCBI taxonomy Id: 264731
Other names: P. ruminicola 23, Prevotella ruminicola 23, Prevotella ruminicola Bryant 23, Prevotella ruminicola str. 23, Prevotella ruminicola strain 23
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.