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citG citG acoL acoL acoC acoC pycA pycA citB citB citA citA pdhD pdhD pdhC pdhC pdhB pdhB pdhA pdhA bfmBC bfmBC odhB odhB odhA odhA sucC sucC sucD sucD BL01100 BL01100 BL01099 BL01099 pckA pckA mmgD mmgD citZ citZ icd icd mdh mdh sdhC sdhC sdhA sdhA sdhB sdhB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
citGFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
acoLAcetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). (458 aa)
acoCAcetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (377 aa)
pycAPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
citBAconitate hydratase (aconitase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (908 aa)
citACitrate synthase I; Belongs to the citrate synthase family. (363 aa)
pdhDDihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. (470 aa)
pdhCPyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit). (430 aa)
pdhBPyruvate dehydrogenase (E1 beta subunit). (325 aa)
pdhAPyruvate dehydrogenase (E1 alpha subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
bfmBCBranched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). (473 aa)
odhB2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (426 aa)
odhA2-oxoglutarate dehydrogenase (E1 subunit); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (944 aa)
sucCsuccinyl-CoA synthetase (beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase (alpha subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
BL01100Conserved hypothetical protein. (421 aa)
BL01099Putative oxidoreductase. (585 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa)
mmgDCitrate synthase III; Belongs to the citrate synthase family. (371 aa)
citZCitrate synthase II; Belongs to the citrate synthase family. (372 aa)
icdIsocitrate dehydrogenase. (423 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
sdhCSuccinate dehydrogenase (cytochrome b558 subunit). (202 aa)
sdhASuccinate dehydrogenase (flavoprotein subunit). (587 aa)
sdhBSuccinate dehydrogenase (iron-sulfur protein). (254 aa)
Your Current Organism:
Bacillus licheniformis
NCBI taxonomy Id: 279010
Other names: B. licheniformis DSM 13 = ATCC 14580, Bacillus licheniformis ATCC 14580, Bacillus licheniformis ATCC 14580 = DSM 13, Bacillus licheniformis DSM 13, Bacillus licheniformis DSM 13 = ATCC 14580
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