(12 nodes) Neutral amino acid transport network (Schizosaccharomyces pombe)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vba2	Uncharacterized transporter C460.03. (567 aa)
	SPCPB1C11.03	Uncharacterized transporter PB1C11.03. (570 aa)
	SPBPB10D8.01	Uncharacterized transporter PB10D8.01. (552 aa)
	hem25	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (296 aa)
	ymc1	Uncharacterized mitochondrial carrier C4G9.20c. (298 aa)
	fnx1	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds. (531 aa)
	avt5	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family. (420 aa)
	put4	Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. (552 aa)
	per1	Uncharacterized amino-acid permease P7G5.06. (583 aa)
	fnx2	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily. (577 aa)
	agp3	Uncharacterized amino-acid permease C965.11c. (537 aa)
	fsf1	Sideroflexin fsf1; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family. (322 aa)

Your Current Organism:

Schizosaccharomyces pombe

NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPBPB10D8.01	per1	Q9C0V8	Q9P768	Uncharacterized transporter PB10D8.01.	Uncharacterized amino-acid permease P7G5.06.	0.605
SPBPB10D8.01	put4	Q9C0V8	Q9URZ3	Uncharacterized transporter PB10D8.01.	Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.	0.483
SPBPB10D8.01	vba2	Q9C0V8	B5BP47	Uncharacterized transporter PB10D8.01.	Uncharacterized transporter C460.03.	0.724
SPCPB1C11.03	per1	Q9C0U9	Q9P768	Uncharacterized transporter PB1C11.03.	Uncharacterized amino-acid permease P7G5.06.	0.595
SPCPB1C11.03	put4	Q9C0U9	Q9URZ3	Uncharacterized transporter PB1C11.03.	Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.	0.800
agp3	fnx1	O59831	Q09752	Uncharacterized amino-acid permease C965.11c.	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.	0.595
agp3	fnx2	O59831	O59726	Uncharacterized amino-acid permease C965.11c.	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.	0.737
agp3	per1	O59831	Q9P768	Uncharacterized amino-acid permease C965.11c.	Uncharacterized amino-acid permease P7G5.06.	0.500
avt5	fnx1	O74327	Q09752	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.	0.777
avt5	fnx2	O74327	O59726	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.	0.877
avt5	vba2	O74327	B5BP47	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.	Uncharacterized transporter C460.03.	0.877
fnx1	agp3	Q09752	O59831	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.	Uncharacterized amino-acid permease C965.11c.	0.595
fnx1	avt5	Q09752	O74327	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.	0.777
fnx1	put4	Q09752	Q9URZ3	Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.	Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.	0.624
fnx2	agp3	O59726	O59831	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.	Uncharacterized amino-acid permease C965.11c.	0.737
fnx2	avt5	O59726	O74327	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.	Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.	0.877
fnx2	put4	O59726	Q9URZ3	Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.	Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.	0.668
fsf1	hem25	O13793	Q9P6N6	Sideroflexin fsf1; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family.	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	0.551
hem25	fsf1	Q9P6N6	O13793	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	Sideroflexin fsf1; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family.	0.551
per1	SPBPB10D8.01	Q9P768	Q9C0V8	Uncharacterized amino-acid permease P7G5.06.	Uncharacterized transporter PB10D8.01.	0.605