(5 nodes) (2019) A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing. network (Schizosaccharomyces pombe)

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Your Input:
	cdc42	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (192 aa)
	cdc15	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa)
	SPAC23D3.13c	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity). (1616 aa)
	cdc12	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily. (1841 aa)
	gef1	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42. (753 aa)

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Schizosaccharomyces pombe

NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPAC23D3.13c	cdc15	Q09853	Q09822	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	0.424
SPAC23D3.13c	cdc42	Q09853	Q01112	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.935
SPAC23D3.13c	gef1	Q09853	Q09763	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	0.872
cdc12	cdc15	Q10059	Q09822	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	0.998
cdc12	cdc42	Q10059	Q01112	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.984
cdc12	gef1	Q10059	Q09763	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	0.461
cdc15	SPAC23D3.13c	Q09822	Q09853	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	0.424
cdc15	cdc12	Q09822	Q10059	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	0.998
cdc15	cdc42	Q09822	Q01112	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.750
cdc15	gef1	Q09822	Q09763	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	0.587
cdc42	SPAC23D3.13c	Q01112	Q09853	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	0.935
cdc42	cdc12	Q01112	Q10059	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	0.984
cdc42	cdc15	Q01112	Q09822	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	0.750
cdc42	gef1	Q01112	Q09763	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	0.989
gef1	SPAC23D3.13c	Q09763	Q09853	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).	0.872
gef1	cdc12	Q09763	Q10059	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.	0.461
gef1	cdc15	Q09763	Q09822	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.	0.587
gef1	cdc42	Q09763	Q01112	Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.	Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.989