(14 nodes) Pantothenate and CoA biosynthesis network (Acetivibrio ethanolgignens)

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Your Input:
	KSV58656.1	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
	KSV58076.1	Pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
	ilvD	Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (553 aa)
	KSV57441.1	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
	KSV57505.1	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (610 aa)
	acpS	ACP synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (133 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
	KSV59863.1	Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
	KSV59718.1	Phenylhydantoinase; Catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
	coaD	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
	coaE	Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
	KSV58507.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
	coaX	Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa)
	KSV57569.1	Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa)

Your Current Organism:

Acetivibrio ethanolgignens

NCBI taxonomy Id: 290052
Other names: A. ethanolgignens, ATCC 33324, Acetivibrio ethanoligignens, DSM 3005, LMG 7055, LMG:7055, strain 77-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KSV57441.1	KSV57505.1	ASU35_04485	ASU35_04830	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.702
KSV57441.1	KSV58656.1	ASU35_04485	ASU35_02310	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.761
KSV57441.1	KSV59863.1	ASU35_04485	ASU35_07625	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KSV57441.1	ilvC	ASU35_04485	ASU35_07620	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.993
KSV57441.1	ilvD	ASU35_04485	ASU35_04480	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.995
KSV57505.1	KSV57441.1	ASU35_04830	ASU35_04485	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.702
KSV57505.1	KSV58656.1	ASU35_04830	ASU35_02310	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.761
KSV57505.1	KSV59863.1	ASU35_04830	ASU35_07625	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
KSV57505.1	ilvC	ASU35_04830	ASU35_07620	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.980
KSV57505.1	ilvD	ASU35_04830	ASU35_04480	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.949
KSV57569.1	coaD	ASU35_15910	ASU35_08470	Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.	0.925
KSV57569.1	coaE	ASU35_15910	ASU35_10040	Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.	Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.659
KSV57569.1	coaX	ASU35_15910	ASU35_15905	Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.	Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.	0.944
KSV58076.1	coaE	ASU35_03310	ASU35_10040	Pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.633
KSV58076.1	coaX	ASU35_03310	ASU35_15905	Pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.	0.619
KSV58507.1	coaE	ASU35_12645	ASU35_10040	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.413
KSV58656.1	KSV57441.1	ASU35_02310	ASU35_04485	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.761
KSV58656.1	KSV57505.1	ASU35_02310	ASU35_04830	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.761
KSV58656.1	KSV59863.1	ASU35_02310	ASU35_07625	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.810
KSV58656.1	ilvC	ASU35_02310	ASU35_07620	Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.794