STRINGSTRING
CKO_00170 CKO_00170 metE metE pepB pepB CKO_00261 CKO_00261 CKO_00296 CKO_00296 CKO_00365 CKO_00365 CKO_00366 CKO_00366 CKO_00367 CKO_00367 cysA cysA CKO_00369 CKO_00369 CKO_00379 CKO_00379 CKO_00727 CKO_00727 CKO_00830 CKO_00830 cysS cysS CKO_01141 CKO_01141 CKO_01374 CKO_01374 CKO_01563 CKO_01563 CKO_01629 CKO_01629 CKO_01706 CKO_01706 CKO_01707 CKO_01707 CKO_01754 CKO_01754 CKO_01755 CKO_01755 CKO_01896 CKO_01896 CKO_01897 CKO_01897 CKO_01898 CKO_01898 CKO_02129 CKO_02129 CKO_02559 CKO_02559 CKO_02585 CKO_02585 cysS-2 cysS-2 CKO_02713 CKO_02713 CKO_02822 CKO_02822 CKO_02940 CKO_02940 CKO_02941 CKO_02941 CKO_02959 CKO_02959 CKO_03051 CKO_03051 CKO_03055 CKO_03055 CKO_03083 CKO_03083 dgt dgt mtnN mtnN CKO_03210 CKO_03210 CKO_03454 CKO_03454 pepA pepA cysQ cysQ CKO_03855 CKO_03855 CKO_03902 CKO_03902 metAS metAS luxS luxS gshA gshA cysC cysC cysN cysN cysD cysD cysH cysH cysI cysI cysJ cysJ metK metK gshB gshB CKO_04402 CKO_04402 CKO_04539 CKO_04539 glpE glpE CKO_04868 CKO_04868 CKO_04984 CKO_04984 CKO_05064 CKO_05064
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CKO_00170Hypothetical protein; KEGG: shn:Shewana3_3435 1.1e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: Cytoplasmic, score:9.97; Belongs to the LysR transcriptional regulatory family. (317 aa)
metEHypothetical protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
pepBHypothetical protein; Probably plays an important role in intracellular peptide degradation. (427 aa)
CKO_00261Hypothetical protein; KEGG: ssn:SSO_2603 2.3e-132 sseA; putative thiosulfate sulfurtransferase K01011; COG: COG2897 Rhodanese-related sulfurtransferase. (284 aa)
CKO_00296Hypothetical protein; KEGG: pfo:Pfl_0989 6.7e-71 peptidase M17, leucyl aminopeptidase-like K01255; COG: COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family. (440 aa)
CKO_00365Hypothetical protein; COG: COG4150 ABC-type sulfate transport system, periplasmic component; Psort location: Periplasmic, score:10.00. (338 aa)
CKO_00366Hypothetical protein; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
CKO_00367Hypothetical protein; KEGG: pac:PPA0505 1.1e-26 ABC transporter, putative molybdenum transport system K02017:K02018; COG: COG4208 ABC-type sulfate transport system, permease component; Psort location: CytoplasmicMembrane, score:10.00. (291 aa)
cysAHypothetical protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
CKO_00369Hypothetical protein; KEGG: sec:SC2439 1.8e-155 cysM; cysteine synthase B (O-acetylserine sulfhydrolase B) K01738; COG: COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
CKO_00379Hypothetical protein; KEGG: sty:STY2666 1.0e-163 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score:8.96; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
CKO_00727Hypothetical protein; KEGG: stm:STM2114 2.3e-70 wcaB; putative acyl transferase in colanic acid biosynthesis K03819; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score:9.26. (146 aa)
CKO_00830Hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. (411 aa)
cysSHypothetical protein; KEGG: eca:ECA3151 1.2e-151 cysS; cysteinyl-RNA synthetase K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa)
CKO_01141Hypothetical protein; COG: COG1956 GAF domain-containing protein; Psort location: Cytoplasmic, score:8.96. (165 aa)
CKO_01374Hypothetical protein; COG: COG2128 Uncharacterized conserved protein. (385 aa)
CKO_01563Hypothetical protein; KEGG: lsl:LSL_0129 4.2e-78 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score:8.96. (367 aa)
CKO_01629Hypothetical protein; KEGG: ece:Z2627 6.4e-185 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (390 aa)
CKO_01706Hypothetical protein; KEGG: plu:plu0524 1.4e-164 unnamed protein product; similar to cystathionine beta-synthase K01697; COG: COG0031 Cysteine synthase. (456 aa)
CKO_01707Hypothetical protein; KEGG: plu:plu0523 1.2e-149 unnamed protein product; similar to cystathionine gamma-lyase K01758; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (381 aa)
CKO_01754Hypothetical protein; COG: COG1988 Predicted membrane-bound metal-dependent hydrolases. (196 aa)
CKO_01755Hypothetical protein; KEGG: eci:UTI89_C4668 2.4e-36 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
CKO_01896Hypothetical protein; KEGG: wsu:WS1010 5.1e-06 cysH; APS reductase K00390; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96. (414 aa)
CKO_01897Hypothetical protein. (145 aa)
CKO_01898Hypothetical protein; Psort location: Cytoplasmic, score:8.96. (137 aa)
CKO_02129Hypothetical protein; KEGG: stm:STM1057 0. pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: Cytoplasmic, score:9.12. (870 aa)
CKO_02559Hypothetical protein; KEGG: sec:SC0634 8.8e-188 ybdL; putative aminotransferase K00812; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase. (389 aa)
CKO_02585Hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. (372 aa)
cysS-2Hypothetical protein; KEGG: eci:UTI89_C0555 5.3e-245 cysS; cysteinyl-tRNA synthetase (cysteine--tRNA ligase) K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
CKO_02713Hypothetical protein; KEGG: sec:SC0500 8.5e-174 putative cysteine synthase/cystathionine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score:8.96. (351 aa)
CKO_02822Hypothetical protein; KEGG: eco:b0261 1.3e-145 mmuM, yagD; CP4-6 prophage; S-methylmethionine:homocysteine methyltransferase K00547; COG: COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (310 aa)
CKO_02940Hypothetical protein; COG: NOG05997 non supervised orthologous group. (327 aa)
CKO_02941Hypothetical protein; KEGG: eca:ECA3126 2.3e-171 metE; 5-methyltetrahydropteroyltriglutamate- homocystein e methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score:8.96. (343 aa)
CKO_02959Hypothetical protein; KEGG: ece:Z0298 1.7e-225 pepD; aminoacyl-histidine dipeptidase (peptidase D) K01270; COG: COG2195 Di- and tripeptidases; Psort location: Cytoplasmic, score:8.96. (449 aa)
CKO_03051Hypothetical protein; KEGG: stt:t3511 5.6e-154 metF; 5,10 methylenetetrahydrofolate reductase K00297; COG: COG0685 5,10-methylenetetrahydrofolate reductase; Psort location: Cytoplasmic, score:8.96. (296 aa)
CKO_03055Hypothetical protein; KEGG: eco:b3939 2.8e-198 metB, met-1, met1; cystathionine gamma-synthase K01739; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (386 aa)
CKO_03083Hypothetical protein; COG: COG1613 ABC-type sulfate transport system, periplasmic component; Psort location: Periplasmic, score:10.00. (329 aa)
dgtHypothetical protein; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (504 aa)
mtnNHypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa)
CKO_03210COG: COG2860 Predicted membrane protein; Psort location: CytoplasmicMembrane, score:10.00. (207 aa)
CKO_03454Hypothetical protein; KEGG: sfl:SF3053 3.6e-159 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (396 aa)
pepAHypothetical protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa)
cysQHypothetical protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa)
CKO_03855Hypothetical protein; KEGG: eco:b4054 8.6e-197 tyrB; tyrosine aminotransferase, tyrosine repressible K00832; COG: COG1448 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:9.97. (397 aa)
CKO_03902Hypothetical protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1247 aa)
metASHypothetical protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
luxSHypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
gshAHypothetical protein; KEGG: spt:SPA2677 1.2e-270 gshA; gamma-glutamylcysteine synthetase K01919; COG: COG2918 Gamma-glutamylcysteine synthetase; Psort location: Cytoplasmic, score:8.96; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
cysCHypothetical protein; Catalyzes the synthesis of activated sulfate. (201 aa)
cysNHypothetical protein; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa)
cysDHypothetical protein; KEGG: ecp:ECP_2734 3.9e-162 sulfate adenylyltransferase subunit 2 K00957; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96. (302 aa)
cysHHypothetical protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
cysIHypothetical protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
cysJHypothetical protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (601 aa)
metKHypothetical protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
gshBHypothetical protein; KEGG: eci:UTI89_C3336 1.9e-162 gshB; glutathione synthetase K01920; COG: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Psort location: Cytoplasmic, score:8.96. (315 aa)
CKO_04402Hypothetical protein; KEGG: ecc:c3742 8.1e-201 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (421 aa)
CKO_04539Hypothetical protein; KEGG: ecc:c1175 1.0e-184 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Psort location: Cytoplasmic, score:8.96. (390 aa)
glpEHypothetical protein; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (108 aa)
CKO_04868Hypothetical protein; KEGG: sec:SC3480 8.2e-295 ggt; gamma-glutamyltranspeptidase K00681; COG: COG0405 Gamma-glutamyltransferase; Psort location: Periplasmic, score:10.00. (603 aa)
CKO_04984Hypothetical protein; KEGG: tde:TDE2200 6.7e-126 megL; methionine gamma-lyase K01761; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (398 aa)
CKO_05064Hypothetical protein; KEGG: sdy:SDY_4040 2.0e-142 cysE; serine acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score:9.26; Belongs to the transferase hexapeptide repeat family. (273 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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