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fixA fixA argG argG ileS ileS CKO_03367 CKO_03367 CKO_03396 CKO_03396 CKO_03463 CKO_03463 CKO_03497 CKO_03497 CKO_03507 CKO_03507 valS valS trpS trpS CKO_03841 CKO_03841 cysD cysD cysH cysH CKO_04125 CKO_04125 CKO_04943 CKO_04943 hldE hldE CKO_04126 CKO_04126 guaA guaA gltX gltX metG metG cysS cysS CKO_01055 CKO_01055 argS argS ttcA ttcA CKO_01420 CKO_01420 CKO_01446 CKO_01446 CKO_01536 CKO_01536 coaD coaD tyrS tyrS nadE nadE CKO_01830 CKO_01830 mnmA mnmA CKO_01896 CKO_01896 CKO_02466 CKO_02466 glnS glnS CKO_02490 CKO_02490 leuS leuS nadD nadD CKO_02541 CKO_02541 CKO_02557 CKO_02557 cysS-2 cysS-2 queC queC thiI thiI tilS tilS gluQ gluQ panC panC CKO_03340 CKO_03340
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fixAHypothetical protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (268 aa)
argGHypothetical protein; KEGG: sty:STY3470 1.8e-237 argG; argininosuccinate synthetase K01940; COG: COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
ileSHypothetical protein; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa)
CKO_03367Hypothetical protein; KEGG: ecs:ECs0028 8.2e-153 riboflavin kinase / FMN adenylyltransferase K00861:K00953; COG: COG0196 FAD synthase; Psort location: Cytoplasmic, score:8.96; Belongs to the ribF family. (312 aa)
CKO_03396Hypothetical protein; KEGG: stm:STM4580.S 1.5e-217 nadR; nicotinamide-nucleotide adenylyltransferase K00952:K06210:K06211; COG: COG3172 Predicted ATPase/kinase involved in NAD metabolism; Psort location: Cytoplasmic, score:8.96. (410 aa)
CKO_03463Hypothetical protein; KEGG: sec:SC4363 1.4e-157 trpS2; putative tryptophanyl-tRNA synthetase K01867; COG: COG0180 Tryptophanyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa)
CKO_03497Hypothetical protein; KEGG: fnu:FN0444 1.0e-05 phosphoadenosine phosphosulfate reductase K00390; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96. (544 aa)
CKO_03507Hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (446 aa)
valSHypothetical protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (951 aa)
trpSHypothetical protein; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
CKO_03841COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: Cytoplasmic, score:8.96. (143 aa)
cysDHypothetical protein; KEGG: ecp:ECP_2734 3.9e-162 sulfate adenylyltransferase subunit 2 K00957; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96. (302 aa)
cysHHypothetical protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
CKO_04125Hypothetical protein; KEGG: fnu:FN1424 5.0e-08 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: Cytoplasmic, score:8.96. (284 aa)
CKO_04943Hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (144 aa)
hldEHypothetical protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (477 aa)
CKO_04126Hypothetical protein; COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: Cytoplasmic, score:8.96. (260 aa)
guaAHypothetical protein; Catalyzes the synthesis of GMP from XMP. (525 aa)
gltXHypothetical protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa)
metGHypothetical protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (677 aa)
cysSHypothetical protein; KEGG: eca:ECA3151 1.2e-151 cysS; cysteinyl-RNA synthetase K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa)
CKO_01055Hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (142 aa)
argSHypothetical protein; KEGG: eco:b1876 1.0e-296 argS, lov; arginine tRNA synthetase K01887; COG: COG0018 Arginyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97. (577 aa)
ttcAHypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (311 aa)
CKO_01420COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: Cytoplasmic, score:8.96. (144 aa)
CKO_01446Hypothetical protein; COG: COG1434 Uncharacterized conserved protein. (266 aa)
CKO_01536COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: Cytoplasmic, score:8.96. (142 aa)
coaDHypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
tyrSHypothetical protein; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (428 aa)
nadEHypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)
CKO_01830COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins. (142 aa)
mnmAHypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (383 aa)
CKO_01896Hypothetical protein; KEGG: wsu:WS1010 5.1e-06 cysH; APS reductase K00390; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score:8.96. (414 aa)
CKO_02466Hypothetical protein; KEGG: eco:b0695 0. kdpD, kac; sensor for high-affinity potassium transport system K07646; COG: COG2205 Osmosensitive K+ channel histidine kinase; Psort location: CytoplasmicMembrane, score:9.99. (895 aa)
glnSHypothetical protein; KEGG: spt:SPA2055 8.6e-300 glnS; glutaminyl-tRNA synthetase K01886; COG: COG0008 Glutamyl- and glutaminyl-tRNA synthetases; Psort location: Cytoplasmic, score:8.96. (555 aa)
CKO_02490Hypothetical protein; KEGG: stm:STM0680 1.3e-294 asnB; asparagine synthetase B K01953; COG: COG0367 Asparagine synthase (glutamine-hydrolyzing); Psort location: Cytoplasmic, score:8.96. (558 aa)
leuSHypothetical protein; KEGG: ecc:c0733 0. leuS; leucyl-tRNA synthetase K01869; COG: COG0495 Leucyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.26; Belongs to the class-I aminoacyl-tRNA synthetase family. (868 aa)
nadDHypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa)
CKO_02541Hypothetical protein; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (358 aa)
CKO_02557Hypothetical protein; KEGG: eci:UTI89_C2238 1.5e-146 ibrA; hypothetical protein YbdN K00390; COG: COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase. (411 aa)
cysS-2Hypothetical protein; KEGG: eci:UTI89_C0555 5.3e-245 cysS; cysteinyl-tRNA synthetase (cysteine--tRNA ligase) K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: Cytoplasmic, score:9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
queCHypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
thiIHypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (440 aa)
gluQHypothetical protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (298 aa)
panCHypothetical protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (307 aa)
CKO_03340Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. (293 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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