STRINGSTRING
TRAF2 TRAF2 PARP9 PARP9 IL7 IL7 HIF1A HIF1A RIPK2 RIPK2 STING1 STING1 RNF185 RNF185 MED1 MED1 TRIM44 TRIM44 EDN1 EDN1 RIPK1 RIPK1 LSM14A LSM14A TBK1 TBK1 CSF1 CSF1 TREM2 TREM2 PARK2-2 PARK2-2 ENSUMAP00000015922 ENSUMAP00000015922 PARK2 PARK2 TRIM56 TRIM56 GFI1 GFI1 PAFAH1B1 PAFAH1B1 CD300LF CD300LF FADD FADD CXCR4 CXCR4 AXL AXL NLRP6 NLRP6 TRIM32 TRIM32 ENSUMAP00000005498 ENSUMAP00000005498 CPNE1 CPNE1 MAVS MAVS IKBKE IKBKE CD74 CD74 ZBP1 ZBP1 IRF3 IRF3 TXK TXK UBE2K UBE2K HPX HPX TREML1 TREML1 GAS6 GAS6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (827 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
STING1Stimulator of interferon genes protein. (378 aa)
RNF185E3 ubiquitin-protein ligase RNF185. (192 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
TRIM44Tripartite motif-containing protein 44. (516 aa)
EDN1Endothelin-1. (202 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
LSM14AProtein LSM14 homolog A isoform X1. (440 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
ENSUMAP00000015922annotation not available (110 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
TRIM56E3 ubiquitin-protein ligase TRIM56. (716 aa)
GFI1Growth factor independent 1 transcriptional repressor. (135 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
CD300LFCMRF35-like molecule 1 isoform X1. (307 aa)
FADDFAS-associated death domain protein. (192 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (795 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
ENSUMAP00000005498annotation not available (97 aa)
CPNE1Copine-1. (537 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
ZBP1Z-DNA-binding protein 1 isoform X1. (444 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
TXKTyrosine-protein kinase. (527 aa)
UBE2KUbiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
HPXHemopexin. (396 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
GAS6LOW QUALITY PROTEIN: growth arrest-specific protein 6. (614 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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