65 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLRC5	Protein NLRC5. (1728 aa)
	LRRC7	Leucine-rich repeat-containing protein 7. (1544 aa)
	NWD2	NACHT and WD repeat domain-containing protein 2. (1723 aa)
	FOXP3	Forkhead box protein P3. (314 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
	ENSUMAP00000009501	annotation not available (97 aa)
	CACTIN	Cactin. (189 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (404 aa)
	ERBIN	Protein LAP2 isoform X1. (1472 aa)
	RWDD3	RWD domain-containing protein 3 isoform X1. (208 aa)
	LOC103659111	LOW QUALITY PROTEIN: coiled-coil domain-containing protein 22-like. (621 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10. (297 aa)
	ENSUMAP00000014414	annotation not available (310 aa)
	COMMD6	COMM domain-containing protein 6. (85 aa)
	BRMS1	Breast cancer metastasis-suppressor 1. (348 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	NLRP12	NACHT, LRR and PYD domains-containing protein 12. (552 aa)
	ENSUMAP00000015418	annotation not available (242 aa)
	ENSUMAP00000015424	annotation not available (80 aa)
	NWD1	LOW QUALITY PROTEIN: NACHT and WD repeat domain-containing protein 1. (1555 aa)
	ENSUMAP00000018906	annotation not available (223 aa)
	ADORA3	Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	LOC103671894	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (172 aa)
	NFKBIL1	NF-kappa-B inhibitor-like protein 1 isoform X1. (366 aa)
	CDK5RAP3	LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 3. (149 aa)
	ENSUMAP00000021840	annotation not available (165 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (486 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (632 aa)
	TRIM40	LOW QUALITY PROTEIN: tripartite motif-containing protein 40. (262 aa)
	NFKBIB	LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta. (360 aa)
	LRRC14	Leucine-rich repeat-containing protein 14 isoform X2. (219 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3. (517 aa)
	COMMD1	Copper metabolism domain containing 1. (188 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	SETD6	N-lysine methyltransferase SETD6. (383 aa)
	UFL1	E3 UFM1-protein ligase 1. (792 aa)
	OTULIN	Ubiquitin thioesterase otulin. (317 aa)
	OTULINL	OTU deubiquitinase with linear linkage specificity like. (327 aa)
	DAP	Death-associated protein 1. (77 aa)
	TRAIP	E3 ubiquitin-protein ligase TRAIP. (469 aa)
	TRIM37	E3 ubiquitin-protein ligase TRIM37 isoform X3. (963 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
	BCL3	B-cell lymphoma 3 protein. (355 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (714 aa)
	COMMD7	COMM domain-containing protein 7. (184 aa)
	PTGIS	Prostacyclin synthase; Belongs to the cytochrome P450 family. (485 aa)
	PRMT2	Protein arginine N-methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
	CYLD	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (948 aa)
	CMKLR1	Chemerin chemokine-like receptor 1. (360 aa)
	TRIM21	E3 ubiquitin-protein ligase TRIM21. (469 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	PKHD1	LOW QUALITY PROTEIN: fibrocystin. (4039 aa)
	USP7	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1086 aa)
	DAB2IP	Disabled homolog 2-interacting protein. (877 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2 isoform X1. (280 aa)
	TAX1BP1	Tax1-binding protein 1 isoform X2. (757 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (486 aa)
	NLRC3	Protein NLRC3. (1085 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
	LOC103674831	Transcription elongation factor A protein-like 7 isoform X1. (100 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA3	ENSUMAP00000018906	ENSUMAP00000018910	ENSUMAP00000018906	Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	annotation not available	0.959
BCL3	CHUK	ENSUMAP00000032162	ENSUMAP00000031552	B-cell lymphoma 3 protein.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.516
BCL3	CYLD	ENSUMAP00000032162	ENSUMAP00000007602	B-cell lymphoma 3 protein.	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.437
BCL3	NFKBIB	ENSUMAP00000032162	ENSUMAP00000026412	B-cell lymphoma 3 protein.	LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta.	0.428
CDK5RAP3	ENSUMAP00000021840	ENSUMAP00000021834	ENSUMAP00000021840	LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 3.	annotation not available	0.900
CDK5RAP3	UFL1	ENSUMAP00000021834	ENSUMAP00000029894	LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 3.	E3 UFM1-protein ligase 1.	0.819
CHUK	BCL3	ENSUMAP00000031552	ENSUMAP00000032162	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	B-cell lymphoma 3 protein.	0.516
CHUK	CYLD	ENSUMAP00000031552	ENSUMAP00000007602	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.886
CHUK	IRAK2	ENSUMAP00000031552	ENSUMAP00000025559	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Interleukin-1 receptor-associated kinase-like 2.	0.657
CHUK	LRRC14	ENSUMAP00000031552	ENSUMAP00000026643	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Leucine-rich repeat-containing protein 14 isoform X2.	0.937
CHUK	NFKBIA	ENSUMAP00000031552	ENSUMAP00000015252	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor alpha.	0.998
CHUK	NFKBIB	ENSUMAP00000031552	ENSUMAP00000026412	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta.	0.845
CHUK	NLRC5	ENSUMAP00000031552	ENSUMAP00000000559	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Protein NLRC5.	0.970
CHUK	NOD2	ENSUMAP00000031552	ENSUMAP00000007686	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Nucleotide-binding oligomerization domain-containing protein 2.	0.521
CHUK	PELI1	ENSUMAP00000031552	ENSUMAP00000028938	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.489
CHUK	RBCK1	ENSUMAP00000031552	ENSUMAP00000001068	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	ranBP-type and C3HC4-type zinc finger-containing protein 1.	0.596
CHUK	TNFAIP3	ENSUMAP00000031552	ENSUMAP00000033041	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Tumor necrosis factor alpha-induced protein 3.	0.621
CHUK	TRAF3	ENSUMAP00000031552	ENSUMAP00000008025	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.854
COMMD1	COMMD6	ENSUMAP00000028811	ENSUMAP00000014740	Copper metabolism domain containing 1.	COMM domain-containing protein 6.	0.948
COMMD1	COMMD7	ENSUMAP00000028811	ENSUMAP00000033544	Copper metabolism domain containing 1.	COMM domain-containing protein 7.	0.832