34 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NTF4	LOW QUALITY PROTEIN: neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
	DAB2IP	Disabled homolog 2-interacting protein. (877 aa)
	TRAF1	TNF receptor-associated factor. (408 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	TNFSF8	Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (215 aa)
	TNFSF15	Tumor necrosis factor ligand superfamily member 15. (174 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	TNFSF9	Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (212 aa)
	CD70	CD70 antigen; Belongs to the tumor necrosis factor family. (195 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14; Belongs to the tumor necrosis factor family. (245 aa)
	NGF	Beta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
	TRAF4	TNF receptor-associated factor. (435 aa)
	FEM1B	Protein fem-1 homolog B. (627 aa)
	EDARADD	ectodysplasin-A receptor-associated adapter protein. (208 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
	TNFSF13	Tumor necrosis factor ligand superfamily member 13-like isoform X1; Belongs to the tumor necrosis factor family. (242 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	TMBIM1	Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
	TNFSF18	Tumor necrosis factor ligand superfamily member 18. (178 aa)
	TNFSF4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	BABAM2	BRCA1-A complex subunit BRE isoform X1. (383 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
	TNFSF13B	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (293 aa)
	TRIM37	E3 ubiquitin-protein ligase TRIM37 isoform X3. (963 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
	SIVA1	Apoptosis regulatory protein Siva. (216 aa)
	EDA	ectodysplasin-A; Belongs to the tumor necrosis factor family. (242 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40LG	CD70	ENSUMAP00000014138	ENSUMAP00000015306	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD70 antigen; Belongs to the tumor necrosis factor family.	0.731
CD40LG	FASLG	ENSUMAP00000014138	ENSUMAP00000027494	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.584
CD40LG	LTA	ENSUMAP00000014138	ENSUMAP00000020608	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.671
CD40LG	TNF	ENSUMAP00000014138	ENSUMAP00000020603	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.778
CD40LG	TNFSF11	ENSUMAP00000014138	ENSUMAP00000021848	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family.	0.614
CD40LG	TNFSF13B	ENSUMAP00000014138	ENSUMAP00000031250	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family.	0.723
CD40LG	TNFSF14	ENSUMAP00000014138	ENSUMAP00000015319	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member 14; Belongs to the tumor necrosis factor family.	0.656
CD40LG	TNFSF4	ENSUMAP00000014138	ENSUMAP00000027508	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family.	0.439
CD40LG	TRAF1	ENSUMAP00000014138	ENSUMAP00000005091	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor.	0.519
CD40LG	TRAF2	ENSUMAP00000014138	ENSUMAP00000032192	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.604
CD40LG	TRAF3	ENSUMAP00000014138	ENSUMAP00000008025	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.677
CD40LG	TRAF4	ENSUMAP00000014138	ENSUMAP00000015918	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor.	0.507
CD40LG	TRAF5	ENSUMAP00000014138	ENSUMAP00000029062	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.549
CD70	CD40LG	ENSUMAP00000015306	ENSUMAP00000014138	CD70 antigen; Belongs to the tumor necrosis factor family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.731
CD70	TNFSF18	ENSUMAP00000015306	ENSUMAP00000027500	CD70 antigen; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member 18.	0.466
CD70	TNFSF4	ENSUMAP00000015306	ENSUMAP00000027508	CD70 antigen; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family.	0.470
CD70	TNFSF9	ENSUMAP00000015306	ENSUMAP00000015300	CD70 antigen; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family.	0.607
EDA	EDARADD	ENSUMAP00000001226	ENSUMAP00000018829	ectodysplasin-A; Belongs to the tumor necrosis factor family.	ectodysplasin-A receptor-associated adapter protein.	0.510
EDARADD	EDA	ENSUMAP00000018829	ENSUMAP00000001226	ectodysplasin-A receptor-associated adapter protein.	ectodysplasin-A; Belongs to the tumor necrosis factor family.	0.510
EDARADD	TRAF6	ENSUMAP00000018829	ENSUMAP00000023966	ectodysplasin-A receptor-associated adapter protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.937