STRINGSTRING
PRPF19 PRPF19 STAG3 STAG3 FKBP6 FKBP6 BRCA2 BRCA2 LRWD1 LRWD1 INO80E INO80E NUFIP1 NUFIP1 MCM2 MCM2 PLK1 PLK1 SETD5 SETD5 KAT5 KAT5 C17orf64 C17orf64 CFDP1 CFDP1 BRMS1 BRMS1 POLD4 POLD4 GINS4 GINS4 MCM3 MCM3 A0A4W2BZ05 A0A4W2BZ05 SUN2 SUN2 SYCE1 SYCE1 TONSL TONSL YY1 YY1 POLA2 POLA2 BAZ1A BAZ1A MEI4 MEI4 RAD1 RAD1 POLE POLE SMC1B SMC1B TUBG1 TUBG1 RRS1 RRS1 SPIDR SPIDR MCM4 MCM4 POLD1 POLD1 LRPPRC LRPPRC INO80D INO80D SMARCAL1 SMARCAL1 WDHD1 WDHD1 ORC6 ORC6 A0A4W2CRC2 A0A4W2CRC2 ING3 ING3 XPA XPA BRMS1L BRMS1L RPA2 RPA2 KIFAP3 KIFAP3 INO80 INO80 HNRNPU HNRNPU SYCP2 SYCP2 A0A4W2CWS1 A0A4W2CWS1 SPO11 SPO11 CCNB1IP1 CCNB1IP1 RCC1 RCC1 PINX1 PINX1 CHD1 CHD1 RAD51 RAD51 ORC2 ORC2 TRIM24 TRIM24 ORC3 ORC3 SHOC1 SHOC1 SMC2 SMC2 A0A4W2D2X3 A0A4W2D2X3 CCDC155 CCDC155 WAPL WAPL HSPA2 HSPA2 ACTL6A ACTL6A CDC45 CDC45 NCAPG2 NCAPG2 HORMAD1 HORMAD1 PCNA PCNA ZMIZ2 ZMIZ2 SYCP1 SYCP1 AGO3 AGO3 C14orf39 C14orf39 A0A4W2DD02 A0A4W2DD02 POLE2 POLE2 SIN3B SIN3B SMARCAD1 SMARCAD1 ZRANB3 ZRANB3 DMAP1 DMAP1 ACTR5 ACTR5 NIFK NIFK IK IK ORC1 ORC1 MCM7 MCM7 SLX1A SLX1A MSH4 MSH4 KMT2E KMT2E ACTR8 ACTR8 A0A4W2DR27 A0A4W2DR27 CCDC36 CCDC36 CHEK1 CHEK1 SYCP2L SYCP2L PRIM2 PRIM2 A0A4W2DUI9 A0A4W2DUI9 INCENP INCENP RUVBL1 RUVBL1 SMCHD1 SMCHD1 H2AFY H2AFY RAD9A RAD9A MORF4L1 MORF4L1 NCAPG NCAPG A0A4W2DY12 A0A4W2DY12 TOP2A TOP2A BLM BLM SUDS3 SUDS3 SMARCA5 SMARCA5 SLX4 SLX4 NCAPD2 NCAPD2 MCM10 MCM10 SRCAP SRCAP GINS3 GINS3 ETAA1 ETAA1 POLD3 POLD3 GINS1 GINS1 EP400 EP400 SETX SETX BRCA1 BRCA1 CDC5L CDC5L HDAC1 HDAC1 POLE4 POLE4 HMGA2 HMGA2 HUS1 HUS1 SIRT7 SIRT7 RAD9B RAD9B CPSF6 CPSF6 SMARCB1 SMARCB1 A0A4W2EQA4 A0A4W2EQA4 RNF212B RNF212B MLH3 MLH3 REC8 REC8 TIPIN TIPIN FIGNL1 FIGNL1 NOL6 NOL6 SMC4 SMC4 RPA3 RPA3 BRD8 BRD8 A0A4W2EZ53 A0A4W2EZ53 SINHCAF SINHCAF TOPBP1 TOPBP1 MCM6 MCM6 RSPH1 RSPH1 SYCP3 SYCP3 A0A4W2F3C1 A0A4W2F3C1 SYCE2 SYCE2 LOC113877969 LOC113877969 NFRKB NFRKB HORMAD2 HORMAD2 CDX2 CDX2 POLE3 POLE3 SIN3A SIN3A SFR1 SFR1 TIMELESS TIMELESS PHF12 PHF12 SMC3 SMC3 ING2 ING2 RAD21 RAD21 ACTR6 ACTR6 MCRS1 MCRS1 DNMT3L DNMT3L POLD2 POLD2 INO80C INO80C BCAS2 BCAS2 NEK2 NEK2 MCM5 MCM5 RAD21L1 RAD21L1 ORC5 ORC5 UCHL5 UCHL5 EXOSC9 EXOSC9 MMS22L MMS22L GINS2 GINS2 HELB HELB HDAC2 HDAC2 CHMP1A CHMP1A BAZ1B BAZ1B SAP130 SAP130 INO80B INO80B RPA1 RPA1 PRIM1 PRIM1 SMC1A SMC1A LOC113904482 LOC113904482 ADD3 ADD3 LRIF1 LRIF1 H2AFY2 H2AFY2 TFPT TFPT TEX11 TEX11 RUVBL2 RUVBL2 DHX9 DHX9 DMC1 DMC1 PLRG1 PLRG1 PSMC3IP PSMC3IP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRPF19Pre-mRNA processing factor 19. (504 aa)
STAG3Stromal antigen 3. (1362 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (739 aa)
INO80EINO80 complex subunit E. (244 aa)
NUFIP1Nuclear FMR1 interacting protein 1. (492 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
SETD5SET domain containing 5. (1478 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
CFDP1Craniofacial development protein 1. (377 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
POLD4Uncharacterized protein. (315 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
A0A4W2BZ05Uncharacterized protein. (246 aa)
SUN2Sad1 and UNC84 domain containing 2. (925 aa)
SYCE1Synaptonemal complex central element protein 1. (400 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
YY1YY1 transcription factor. (415 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1557 aa)
MEI4Meiotic double-stranded break formation protein 4. (388 aa)
RAD1RAD1 checkpoint DNA exonuclease. (279 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
SPIDRScaffold protein involved in DNA repair. (831 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
POLD1DNA polymerase. (1106 aa)
LRPPRCLeucine rich pentatricopeptide repeat containing. (1394 aa)
INO80DINO80 complex subunit D. (1026 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
A0A4W2CRC2Uncharacterized protein. (164 aa)
ING3Inhibitor of growth protein. (418 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
BRMS1LUncharacterized protein. (323 aa)
RPA2RPA_C domain-containing protein. (270 aa)
KIFAP3Kinesin associated protein 3. (793 aa)
INO80INO80 complex ATPase subunit. (1584 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
SYCP2Synaptonemal complex protein 2. (1336 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
CCNB1IP1Cyclin B1 interacting protein 1. (277 aa)
RCC1Regulator of chromosome condensation 1. (458 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (309 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1710 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
TRIM24Tripartite motif containing 24. (1016 aa)
ORC3Origin recognition complex subunit 3. (713 aa)
SHOC1Shortage in chiasmata 1. (1439 aa)
SMC2Structural maintenance of chromosomes protein. (1191 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
CCDC155Coiled-coil domain containing 155. (565 aa)
WAPLWAPL cohesin release factor. (1208 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
CDC45Cell division cycle 45. (616 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1140 aa)
HORMAD1HORMA domain containing 1. (392 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (934 aa)
SYCP1Synaptonemal complex protein 1. (980 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (1077 aa)
C14orf39Chromosome 14 open reading frame 39. (466 aa)
A0A4W2DD02MRG domain-containing protein. (235 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
SIN3BSIN3 transcription regulator family member B. (1271 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1096 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (513 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (615 aa)
NIFKNucleolar protein interacting with the FHA domain of MKI67. (362 aa)
IKIK cytokine. (555 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa)
MSH4MutS homolog 4. (934 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (832 aa)
A0A4W2DR27Uncharacterized protein. (293 aa)
CCDC36Coiled-coil domain containing 36. (592 aa)
CHEK1Checkpoint kinase 1. (677 aa)
SYCP2LSynaptonemal complex protein 2 like. (797 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
A0A4W2DUI9Uncharacterized protein. (146 aa)
INCENPInner centromere protein. (877 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa)
H2AFYH2A histone family member Y. (412 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (422 aa)
MORF4L1Mortality factor 4 like 1. (362 aa)
NCAPGNon-SMC condensin I complex subunit G. (1018 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1532 aa)
BLMBLM RecQ like helicase. (1430 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (432 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1422 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (916 aa)
SRCAPUncharacterized protein. (3291 aa)
GINS3GINS complex subunit 3. (216 aa)
ETAA1ETAA1 activator of ATR kinase. (899 aa)
POLD3Uncharacterized protein. (425 aa)
GINS1GINS complex subunit 1. (196 aa)
EP400E1A binding protein p400. (3096 aa)
SETXSenataxin. (2683 aa)
BRCA1BRCA1 DNA repair associated. (1941 aa)
CDC5LCell division cycle 5 like. (802 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (513 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
HMGA2Uncharacterized protein. (109 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
SIRT7Sirtuin 7. (420 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (724 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (436 aa)
A0A4W2EQA4RING-type domain-containing protein. (225 aa)
RNF212BRing finger protein 212B. (300 aa)
MLH3MutL homolog 3. (1514 aa)
REC8REC8 meiotic recombination protein. (579 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa)
FIGNL1Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa)
NOL6Nucleolar protein 6. (1145 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
RPA3Replication protein A3. (121 aa)
BRD8Bromodomain containing 8. (1235 aa)
A0A4W2EZ53MRG domain-containing protein. (258 aa)
SINHCAFSIN3-HDAC complex associated factor. (221 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
RSPH1Radial spoke head component 1. (308 aa)
SYCP3Synaptonemal complex protein 3. (235 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
SYCE2Synaptonemal complex central element protein 2. (214 aa)
LOC113877969Histone H3; Belongs to the histone H3 family. (136 aa)
NFRKBNuclear factor related to kappaB binding protein. (1291 aa)
HORMAD2HORMA domain containing 2. (306 aa)
CDX2Caudal type homeobox 2. (306 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
SFR1SWI5 dependent homologous recombination repair protein 1. (243 aa)
TIMELESSTimeless circadian regulator. (1213 aa)
PHF12PHD finger protein 12. (1004 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
ING2Inhibitor of growth protein. (284 aa)
RAD21RAD21 cohesin complex component. (630 aa)
ACTR6Actin related protein 6; Belongs to the actin family. (396 aa)
MCRS1Microspherule protein 1. (462 aa)
DNMT3LPHD-type domain-containing protein. (386 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
INO80CINO80 complex subunit C. (192 aa)
BCAS2BCAS2 pre-mRNA processing factor. (225 aa)
NEK2NIMA related kinase 2. (445 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
RAD21L1RAD21 cohesin complex component like 1. (555 aa)
ORC5Origin recognition complex subunit 5. (446 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (328 aa)
EXOSC9Exosome component 9. (451 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa)
HELBDNA helicase B. (1136 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
SAP130Sin3A associated protein 130. (1083 aa)
INO80BPAPA-1 domain-containing protein. (373 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
LOC113904482Uncharacterized protein. (293 aa)
ADD3Adducin 3. (706 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (769 aa)
H2AFY2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
TFPTTCF3 fusion partner. (251 aa)
TEX11Testis expressed 11. (918 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
DHX9DExH-box helicase 9. (1287 aa)
DMC1DNA meiotic recombinase 1; Belongs to the RecA family. (340 aa)
PLRG1Pleiotropic regulator 1. (513 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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