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GRWD1 | Glutamate rich WD repeat containing 1. (446 aa) | ||||
CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa) | ||||
DHX9 | DExH-box helicase 9. (1287 aa) | ||||
ZPR1 | ZPR1 zinc finger. (459 aa) | ||||
CENPS | Centromere protein S. (139 aa) | ||||
DDX21 | DExD-box helicase 21. (784 aa) | ||||
A0A4W2HXL3 | Uncharacterized protein. (76 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (157 aa) | ||||
PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) | ||||
MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) | ||||
HELB | DNA helicase B. (1136 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) | ||||
GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa) | ||||
MMS22L | MMS22 like, DNA repair protein. (1243 aa) | ||||
TM4SF19 | Uncharacterized protein. (209 aa) | ||||
ORC5 | Origin recognition complex subunit 5. (446 aa) | ||||
MCM5 | DNA helicase; Belongs to the MCM family. (892 aa) | ||||
RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa) | ||||
SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1061 aa) | ||||
POLD2 | DNA polymerase delta 2, accessory subunit. (580 aa) | ||||
RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa) | ||||
CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (494 aa) | ||||
TIMELESS | Timeless circadian regulator. (1213 aa) | ||||
THOC1 | THO complex 1. (657 aa) | ||||
PURA | Purine rich element binding protein A. (322 aa) | ||||
TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa) | ||||
UPF1 | UPF1 RNA helicase and ATPase. (1127 aa) | ||||
RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) | ||||
SIN3A | SIN3 transcription regulator family member A. (1274 aa) | ||||
POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) | ||||
SMIM26 | Small integral membrane protein 26. (90 aa) | ||||
A0A4W2F3C1 | RPA_C domain-containing protein. (250 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) | ||||
A0A4W2EYQ3 | CAF1C_H4-bd domain-containing protein. (93 aa) | ||||
NASP | Nuclear autoantigenic sperm protein. (1094 aa) | ||||
RBMS1 | RNA binding motif single stranded interacting protein 1. (419 aa) | ||||
RFC1 | Replication factor C subunit 1. (1146 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
RBM48 | RNA binding motif protein 48. (372 aa) | ||||
TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa) | ||||
BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (2982 aa) | ||||
GMNC | Geminin coiled-coil domain containing. (335 aa) | ||||
CHAF1A | Chromatin assembly factor 1 subunit A. (957 aa) | ||||
POLQ | DNA polymerase theta. (2585 aa) | ||||
CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) | ||||
SIRT7 | Sirtuin 7. (420 aa) | ||||
CDT1 | Chromatin licensing and DNA replication factor 1. (600 aa) | ||||
A0A4W2EG77 | D-aminoacyl-tRNA deacylase. (372 aa) | ||||
TOP1MT | DNA topoisomerase I mitochondrial. (560 aa) | ||||
POLE4 | DNA polymerase epsilon 4, accessory subunit. (120 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (906 aa) | ||||
CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) | ||||
GINS1 | GINS complex subunit 1. (196 aa) | ||||
POLD3 | Uncharacterized protein. (425 aa) | ||||
ETAA1 | ETAA1 activator of ATR kinase. (899 aa) | ||||
MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) | ||||
CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) | ||||
GINS3 | GINS complex subunit 3. (216 aa) | ||||
MCM10 | Minichromosome maintenance 10 replication initiation factor. (916 aa) | ||||
SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) | ||||
FBH1 | F-box DNA helicase 1. (1045 aa) | ||||
KIN | Kin17 DNA and RNA binding protein. (392 aa) | ||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (574 aa) | ||||
A0A4W2DZY8 | MOEP19 domain-containing protein. (598 aa) | ||||
RFC5 | Replication factor C subunit 5. (527 aa) | ||||
BLM | BLM RecQ like helicase. (1430 aa) | ||||
A0A4W2DY12 | RPA_C domain-containing protein. (270 aa) | ||||
GMNN | Geminin DNA replication inhibitor. (186 aa) | ||||
LIG3 | DNA ligase. (943 aa) | ||||
PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa) | ||||
TTC38 | Uncharacterized protein. (628 aa) | ||||
DDX50 | DExD-box helicase 50. (737 aa) | ||||
WDR18 | WD repeat domain 18. (431 aa) | ||||
RFC2 | Replication factor C subunit 2. (352 aa) | ||||
RMI1 | RecQ mediated genome instability 1. (624 aa) | ||||
SRPK2 | SRSF protein kinase 2. (754 aa) | ||||
REPIN1 | Replication initiator 1. (614 aa) | ||||
RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa) | ||||
ATAD5 | ATPase family AAA domain containing 5. (1893 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) | ||||
ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa) | ||||
DONSON | Downstream neighbor of SON. (620 aa) | ||||
RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa) | ||||
ZRANB3 | Zinc finger RANBP2-type containing 3. (1096 aa) | ||||
NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (553 aa) | ||||
POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) | ||||
POLK | DNA polymerase kappa. (911 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa) | ||||
RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (298 aa) | ||||
RFC4 | Replication factor C subunit 4. (364 aa) | ||||
NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (569 aa) | ||||
CDC45 | Cell division cycle 45. (616 aa) | ||||
POLN | DNA polymerase nu. (791 aa) | ||||
MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa) | ||||
SSBP1 | Single stranded DNA binding protein 1. (159 aa) | ||||
DDX23 | DEAD-box helicase 23. (909 aa) | ||||
ORC3 | Origin recognition complex subunit 3. (713 aa) | ||||
ORC2 | Origin recognition complex subunit 2. (577 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) | ||||
RTF2 | Replication termination factor 2. (299 aa) | ||||
PCLAF | PAF domain-containing protein. (114 aa) | ||||
PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa) | ||||
A0A4W2CWS1 | RPA_C domain-containing protein. (253 aa) | ||||
SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa) | ||||
RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) | ||||
DSCC1 | DNA replication and sister chromatid cohesion 1. (389 aa) | ||||
RPA2 | RPA_C domain-containing protein. (270 aa) | ||||
A0A4W2CRB3 | BRCT domain-containing protein. (169 aa) | ||||
ORC6 | Origin recognition complex subunit 6. (203 aa) | ||||
POLG | DNA polymerase gamma, catalytic subunit. (1217 aa) | ||||
ING4 | Inhibitor of growth protein. (248 aa) | ||||
WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1127 aa) | ||||
SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa) | ||||
NRM | Nurim. (262 aa) | ||||
POLD1 | DNA polymerase. (1106 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (836 aa) | ||||
SSRP1 | Structure specific recognition protein 1. (852 aa) | ||||
WRN | WRN RecQ like helicase. (1409 aa) | ||||
A0A4W2CIJ2 | Uncharacterized protein. (164 aa) | ||||
FAM111B | Family with sequence similarity 111 member B. (735 aa) | ||||
LIG1 | DNA ligase. (1303 aa) | ||||
KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa) | ||||
A0A4W2CET4 | Uncharacterized protein. (58 aa) | ||||
FANCM | FA complementation group M. (2084 aa) | ||||
BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1557 aa) | ||||
POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa) | ||||
POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) | ||||
OOEP | Oocyte expressed protein. (140 aa) | ||||
RPAIN | RPA interacting protein. (295 aa) | ||||
TICRR | TOPBP1 interacting checkpoint and replication regulator. (1902 aa) | ||||
MCMBP | Minichromosome maintenance complex binding protein. (642 aa) | ||||
RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa) | ||||
CINP | Uncharacterized protein. (212 aa) | ||||
NOC3L | Nucleolar complex protein 3 homolog. (799 aa) | ||||
TONSL | Tonsoku like, DNA repair protein. (1375 aa) | ||||
E4F1 | E4F transcription factor 1. (806 aa) | ||||
PRIMPOL | Primase and DNA directed polymerase. (555 aa) | ||||
MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) | ||||
TRAIP | TRAF interacting protein. (472 aa) | ||||
MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) | ||||
GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (790 aa) | ||||
POLD4 | Uncharacterized protein. (315 aa) | ||||
TBRG1 | Transforming growth factor beta regulator 1. (411 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3420 aa) | ||||
LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (739 aa) | ||||
WRNIP1 | WRN helicase interacting protein 1. (638 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (902 aa) | ||||
ZNF830 | Zinc finger protein 830. (373 aa) | ||||
A0A4W2BUF7 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |