STRINGSTRING
GRWD1 GRWD1 CDC6 CDC6 DHX9 DHX9 ZPR1 ZPR1 CENPS CENPS DDX21 DDX21 A0A4W2HXL3 A0A4W2HXL3 RMI2 RMI2 PRIM1 PRIM1 RPA1 RPA1 MCM8 MCM8 HELB HELB FEN1 FEN1 GINS2 GINS2 MMS22L MMS22L TM4SF19 TM4SF19 ORC5 ORC5 MCM5 MCM5 RRM1 RRM1 SUPT16H SUPT16H DNA2 DNA2 POLD2 POLD2 RTEL1 RTEL1 CDK9 CDK9 TIMELESS TIMELESS THOC1 THOC1 PURA PURA TOP1 TOP1 UPF1 UPF1 RRM2B RRM2B SIN3A SIN3A POLE3 POLE3 SMIM26 SMIM26 A0A4W2F3C1 A0A4W2F3C1 MCM6 MCM6 TOPBP1 TOPBP1 A0A4W2EYQ3 A0A4W2EYQ3 NASP NASP RBMS1 RBMS1 RFC1 RFC1 RPA3 RPA3 RBM48 RBM48 TIPIN TIPIN BOD1L1 BOD1L1 GMNC GMNC CHAF1A CHAF1A POLQ POLQ CCNE2 CCNE2 SIRT7 SIRT7 CDT1 CDT1 A0A4W2EG77 A0A4W2EG77 TOP1MT TOP1MT POLE4 POLE4 GEN1 GEN1 CCNE1 CCNE1 GINS1 GINS1 POLD3 POLD3 ETAA1 ETAA1 MCM9 MCM9 CHTF8 CHTF8 GINS3 GINS3 MCM10 MCM10 SLX4 SLX4 FBH1 FBH1 KIN KIN POLL POLL EME1 EME1 A0A4W2DZY8 A0A4W2DZY8 RFC5 RFC5 BLM BLM A0A4W2DY12 A0A4W2DY12 GMNN GMNN LIG3 LIG3 PRIM2 PRIM2 TTC38 TTC38 DDX50 DDX50 WDR18 WDR18 RFC2 RFC2 RMI1 RMI1 SRPK2 SRPK2 REPIN1 REPIN1 RNASEH2A RNASEH2A ATAD5 ATAD5 MCM7 MCM7 ORC1 ORC1 DONSON DONSON RECQL RECQL ZRANB3 ZRANB3 NFIA NFIA POLE2 POLE2 POLK POLK PCNA PCNA RNASEH1 RNASEH1 RFC4 RFC4 NFIC NFIC CDC45 CDC45 POLN POLN MGME1 MGME1 SSBP1 SSBP1 DDX23 DDX23 ORC3 ORC3 ORC2 ORC2 RAD51 RAD51 NFIB NFIB RTF2 RTF2 PCLAF PCLAF PIF1 PIF1 A0A4W2CWS1 A0A4W2CWS1 SAMHD1 SAMHD1 RBBP4 RBBP4 DSCC1 DSCC1 RPA2 RPA2 A0A4W2CRB3 A0A4W2CRB3 ORC6 ORC6 POLG POLG ING4 ING4 WDHD1 WDHD1 SMARCAL1 SMARCAL1 NRM NRM POLD1 POLD1 MCM4 MCM4 SSRP1 SSRP1 WRN WRN A0A4W2CIJ2 A0A4W2CIJ2 FAM111B FAM111B LIG1 LIG1 KAT7 KAT7 POLE POLE A0A4W2CET4 A0A4W2CET4 FANCM FANCM BAZ1A BAZ1A POLA2 POLA2 POLG2 POLG2 OOEP OOEP RPAIN RPAIN TICRR TICRR MCMBP MCMBP RECQL5 RECQL5 CINP CINP NOC3L NOC3L TONSL TONSL E4F1 E4F1 PRIMPOL PRIMPOL MRE11 MRE11 TRAIP TRAIP MCM3 MCM3 GINS4 GINS4 RFWD3 RFWD3 POLD4 POLD4 TBRG1 TBRG1 RFC3 RFC3 BRCA2 BRCA2 LRWD1 LRWD1 WRNIP1 WRNIP1 MCM2 MCM2 ZNF830 ZNF830 A0A4W2BUF7 A0A4W2BUF7 MUS81 MUS81
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRWD1Glutamate rich WD repeat containing 1. (446 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa)
DHX9DExH-box helicase 9. (1287 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CENPSCentromere protein S. (139 aa)
DDX21DExD-box helicase 21. (784 aa)
A0A4W2HXL3Uncharacterized protein. (76 aa)
RMI2RecQ mediated genome instability 2. (157 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
HELBDNA helicase B. (1136 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
TM4SF19Uncharacterized protein. (209 aa)
ORC5Origin recognition complex subunit 5. (446 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (494 aa)
TIMELESSTimeless circadian regulator. (1213 aa)
THOC1THO complex 1. (657 aa)
PURAPurine rich element binding protein A. (322 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
SMIM26Small integral membrane protein 26. (90 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
A0A4W2EYQ3CAF1C_H4-bd domain-containing protein. (93 aa)
NASPNuclear autoantigenic sperm protein. (1094 aa)
RBMS1RNA binding motif single stranded interacting protein 1. (419 aa)
RFC1Replication factor C subunit 1. (1146 aa)
RPA3Replication protein A3. (121 aa)
RBM48RNA binding motif protein 48. (372 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa)
BOD1L1Biorientation of chromosomes in cell division 1 like 1. (2982 aa)
GMNCGeminin coiled-coil domain containing. (335 aa)
CHAF1AChromatin assembly factor 1 subunit A. (957 aa)
POLQDNA polymerase theta. (2585 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
SIRT7Sirtuin 7. (420 aa)
CDT1Chromatin licensing and DNA replication factor 1. (600 aa)
A0A4W2EG77D-aminoacyl-tRNA deacylase. (372 aa)
TOP1MTDNA topoisomerase I mitochondrial. (560 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
GINS1GINS complex subunit 1. (196 aa)
POLD3Uncharacterized protein. (425 aa)
ETAA1ETAA1 activator of ATR kinase. (899 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
GINS3GINS complex subunit 3. (216 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (916 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
FBH1F-box DNA helicase 1. (1045 aa)
KINKin17 DNA and RNA binding protein. (392 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
A0A4W2DZY8MOEP19 domain-containing protein. (598 aa)
RFC5Replication factor C subunit 5. (527 aa)
BLMBLM RecQ like helicase. (1430 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
LIG3DNA ligase. (943 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
TTC38Uncharacterized protein. (628 aa)
DDX50DExD-box helicase 50. (737 aa)
WDR18WD repeat domain 18. (431 aa)
RFC2Replication factor C subunit 2. (352 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
SRPK2SRSF protein kinase 2. (754 aa)
REPIN1Replication initiator 1. (614 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
DONSONDownstream neighbor of SON. (620 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1096 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (553 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
POLKDNA polymerase kappa. (911 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (298 aa)
RFC4Replication factor C subunit 4. (364 aa)
NFICNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (569 aa)
CDC45Cell division cycle 45. (616 aa)
POLNDNA polymerase nu. (791 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa)
SSBP1Single stranded DNA binding protein 1. (159 aa)
DDX23DEAD-box helicase 23. (909 aa)
ORC3Origin recognition complex subunit 3. (713 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
RTF2Replication termination factor 2. (299 aa)
PCLAFPAF domain-containing protein. (114 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (389 aa)
RPA2RPA_C domain-containing protein. (270 aa)
A0A4W2CRB3BRCT domain-containing protein. (169 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
POLGDNA polymerase gamma, catalytic subunit. (1217 aa)
ING4Inhibitor of growth protein. (248 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
NRMNurim. (262 aa)
POLD1DNA polymerase. (1106 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
SSRP1Structure specific recognition protein 1. (852 aa)
WRNWRN RecQ like helicase. (1409 aa)
A0A4W2CIJ2Uncharacterized protein. (164 aa)
FAM111BFamily with sequence similarity 111 member B. (735 aa)
LIG1DNA ligase. (1303 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
A0A4W2CET4Uncharacterized protein. (58 aa)
FANCMFA complementation group M. (2084 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1557 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
OOEPOocyte expressed protein. (140 aa)
RPAINRPA interacting protein. (295 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1902 aa)
MCMBPMinichromosome maintenance complex binding protein. (642 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa)
CINPUncharacterized protein. (212 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
E4F1E4F transcription factor 1. (806 aa)
PRIMPOLPrimase and DNA directed polymerase. (555 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
TRAIPTRAF interacting protein. (472 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
RFWD3Ring finger and WD repeat domain 3. (790 aa)
POLD4Uncharacterized protein. (315 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
RFC3Replication factor C subunit 3. (356 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (739 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
ZNF830Zinc finger protein 830. (373 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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