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EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (700 aa) | ||||
DMC1 | DNA meiotic recombinase 1; Belongs to the RecA family. (340 aa) | ||||
SFPQ | Splicing factor proline and glutamine rich. (707 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa) | ||||
KDM2A | Lysine demethylase 2A. (1185 aa) | ||||
CDCA5 | Cell division cycle associated 5. (253 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (157 aa) | ||||
ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) | ||||
MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) | ||||
GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa) | ||||
MMS22L | MMS22 like, DNA repair protein. (1243 aa) | ||||
AUNIP | Aurora kinase A and ninein interacting protein. (357 aa) | ||||
RAD51B | RAD51 paralog B. (350 aa) | ||||
BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) | ||||
PARP3 | Poly [ADP-ribose] polymerase. (515 aa) | ||||
A0A4W2BNU5 | Reverse transcriptase domain-containing protein. (1128 aa) | ||||
A0A4W2BP37 | Uncharacterized protein. (74 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3420 aa) | ||||
PPP4C | Serine/threonine-protein phosphatase. (307 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (902 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1172 aa) | ||||
RAD51C | RAD51 paralog C. (442 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) | ||||
A0A4W2BUF7 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) | ||||
PAXX | PAXX non-homologous end joining factor. (224 aa) | ||||
WRN | WRN RecQ like helicase. (1409 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (790 aa) | ||||
GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) | ||||
TM4SF19 | Uncharacterized protein. (209 aa) | ||||
RAD21L1 | RAD21 cohesin complex component like 1. (555 aa) | ||||
MCM5 | DNA helicase; Belongs to the MCM family. (892 aa) | ||||
WDR48 | WD repeat domain 48. (677 aa) | ||||
MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) | ||||
MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) | ||||
A0A4W2BZY5 | Reverse transcriptase domain-containing protein. (738 aa) | ||||
ZSWIM7 | Zinc finger SWIM-type containing 7. (145 aa) | ||||
TONSL | Tonsoku like, DNA repair protein. (1375 aa) | ||||
MTA1 | Metastasis associated 1. (715 aa) | ||||
MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) | ||||
A0A4W2C4K5 | RECA_2 domain-containing protein. (525 aa) | ||||
IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (571 aa) | ||||
DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) | ||||
YY1 | YY1 transcription factor. (415 aa) | ||||
RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa) | ||||
RAD52 | RAD52 homolog, DNA repair protein. (416 aa) | ||||
FSBP | Uncharacterized protein. (966 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa) | ||||
FANCM | FA complementation group M. (2084 aa) | ||||
NIPBL | Nipped-B protein. (2698 aa) | ||||
A0A4W2CCW8 | Reverse transcriptase domain-containing protein. (1148 aa) | ||||
A0A4W2CDR2 | Reverse transcriptase domain-containing protein. (738 aa) | ||||
MEIOC | Meiosis specific with coiled-coil domain. (960 aa) | ||||
PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4122 aa) | ||||
XRCC1 | X-ray repair cross complementing 1. (692 aa) | ||||
GGN | Gametogenetin. (671 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa) | ||||
TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (436 aa) | ||||
A0A4W2CIJ2 | Uncharacterized protein. (164 aa) | ||||
RNF169 | Ring finger protein 169. (708 aa) | ||||
SPIDR | Scaffold protein involved in DNA repair. (831 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (836 aa) | ||||
XRCC5 | X-ray repair cross complementing 5. (813 aa) | ||||
SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa) | ||||
A0A4W2CLZ1 | Reverse transcriptase domain-containing protein. (704 aa) | ||||
EPC1 | Enhancer of polycomb homolog. (842 aa) | ||||
TNKS1BP1 | Tankyrase 1 binding protein 1. (1774 aa) | ||||
AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (849 aa) | ||||
A0A4W2CRB3 | BRCT domain-containing protein. (169 aa) | ||||
A0A4W2CRC2 | Uncharacterized protein. (164 aa) | ||||
A0A4W2CT96 | Reverse transcriptase domain-containing protein. (1169 aa) | ||||
RPA2 | RPA_C domain-containing protein. (270 aa) | ||||
A0A4W2CV54 | Reverse transcriptase domain-containing protein. (798 aa) | ||||
INO80 | INO80 complex ATPase subunit. (1584 aa) | ||||
SMC5 | SMC_N domain-containing protein. (1197 aa) | ||||
SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa) | ||||
A0A4W2CWS1 | RPA_C domain-containing protein. (253 aa) | ||||
PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa) | ||||
SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) | ||||
PARP2 | Poly [ADP-ribose] polymerase. (577 aa) | ||||
UVRAG | UV radiation resistance associated. (1019 aa) | ||||
DDX1 | DEAD-box helicase 1. (740 aa) | ||||
RAD51AP2 | RAD51 associated protein 2. (1074 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1544 aa) | ||||
DCLRE1C | DNA cross-link repair 1C. (710 aa) | ||||
A0A4W2D2X3 | Zinc-hook domain-containing protein. (1440 aa) | ||||
CCDC155 | Coiled-coil domain containing 155. (565 aa) | ||||
DCLRE1B | DNA cross-link repair 1B. (542 aa) | ||||
RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) | ||||
POLN | DNA polymerase nu. (791 aa) | ||||
CDC45 | Cell division cycle 45. (616 aa) | ||||
AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (198 aa) | ||||
A0A4W2D9V3 | Reverse transcriptase domain-containing protein. (738 aa) | ||||
C14orf39 | Chromosome 14 open reading frame 39. (466 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) | ||||
HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1061 aa) | ||||
IFFO2 | Intermediate filament family orphan 2; Belongs to the intermediate filament family. (519 aa) | ||||
APTX | Aprataxin. (347 aa) | ||||
CYREN | Cell cycle regulator of NHEJ. (152 aa) | ||||
SMARCAD1 | Uncharacterized protein. (1029 aa) | ||||
ACTR5 | Actin related protein 5; Belongs to the actin family. (615 aa) | ||||
RAD54L | RAD54 like. (749 aa) | ||||
RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa) | ||||
TDP1 | Tyrosyl-DNA phosphodiesterase 1. (690 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) | ||||
MEIOB | Meiosis specific with OB-fold. (472 aa) | ||||
SIRT6 | Sirtuin 6. (391 aa) | ||||
ZBTB7A | Zinc finger and BTB domain containing 7A. (567 aa) | ||||
SEM1 | Uncharacterized protein. (70 aa) | ||||
PRPF19 | Pre-mRNA processing factor 19. (504 aa) | ||||
SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa) | ||||
ZGRF1 | Zinc finger GRF-type containing 1. (2171 aa) | ||||
HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (859 aa) | ||||
ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (832 aa) | ||||
RMI1 | RecQ mediated genome instability 1. (624 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) | ||||
POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa) | ||||
RAD21 | RAD21 cohesin complex component. (630 aa) | ||||
SFR1 | SWI5 dependent homologous recombination repair protein 1. (243 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) | ||||
MBTD1 | Mbt domain containing 1. (692 aa) | ||||
TDP2 | Tyrosyl-DNA phosphodiesterase 2. (364 aa) | ||||
INIP | INTS3 and NABP interacting protein. (104 aa) | ||||
EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) | ||||
INTS3 | Integrator complex subunit 3. (1040 aa) | ||||
APLF | Aprataxin and PNKP like factor. (509 aa) | ||||
SLFNL1 | Schlafen like 1. (383 aa) | ||||
NABP2 | Nucleic acid binding protein 2. (211 aa) | ||||
A0A4W2F400 | Uncharacterized protein. (410 aa) | ||||
A0A4W2F3C1 | RPA_C domain-containing protein. (250 aa) | ||||
XRCC4 | X-ray repair cross complementing 4. (333 aa) | ||||
A0A4W2F1E0 | Uncharacterized protein. (244 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) | ||||
A0A4W2EZ53 | MRG domain-containing protein. (258 aa) | ||||
A0A4W2EYF1 | Reverse transcriptase domain-containing protein. (738 aa) | ||||
ANKLE1 | Ankyrin repeat and LEM domain containing 1. (667 aa) | ||||
BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) | ||||
PSMD14 | Proteasome 26S subunit, non-ATPase 14. (320 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
A0A4W2EVH0 | Uncharacterized protein. (420 aa) | ||||
ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (421 aa) | ||||
HELQ | Helicase, POLQ like. (1092 aa) | ||||
XRCC2 | X-ray repair cross complementing 2. (319 aa) | ||||
UIMC1 | Ubiquitin interaction motif containing 1. (753 aa) | ||||
ZFYVE26 | Zinc finger FYVE-type containing 26. (2531 aa) | ||||
REC8 | REC8 meiotic recombination protein. (579 aa) | ||||
A0A4W2ERQ5 | Reverse transcriptase domain-containing protein. (1152 aa) | ||||
CDC7 | Cell division cycle 7. (576 aa) | ||||
DTX3L | Deltex E3 ubiquitin ligase 3L. (739 aa) | ||||
ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa) | ||||
POLQ | DNA polymerase theta. (2585 aa) | ||||
PNKP | Polynucleotide kinase 3'-phosphatase. (550 aa) | ||||
REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3133 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) | ||||
FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1228 aa) | ||||
SMC6 | Structural maintenance of chromosomes 6. (1098 aa) | ||||
UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (212 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (906 aa) | ||||
MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) | ||||
BRCA1 | BRCA1 DNA repair associated. (1941 aa) | ||||
SETX | Senataxin. (2683 aa) | ||||
VCP | Valosin containing protein; Belongs to the AAA ATPase family. (816 aa) | ||||
MARF1 | Meiosis regulator and mRNA stability factor 1. (1742 aa) | ||||
MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) | ||||
MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa) | ||||
LIG3 | DNA ligase. (943 aa) | ||||
RAD51D | RAD51 paralog D. (418 aa) | ||||
DCLRE1A | DNA cross-link repair 1A. (1045 aa) | ||||
FANCD2 | FA complementation group D2. (1446 aa) | ||||
NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (369 aa) | ||||
SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) | ||||
PALB2 | Partner and localizer of BRCA2. (1195 aa) | ||||
MORF4L1 | Mortality factor 4 like 1. (362 aa) | ||||
A0A4W2DY12 | RPA_C domain-containing protein. (270 aa) | ||||
BLM | BLM RecQ like helicase. (1430 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) | ||||
XRCC6 | X-ray repair cross complementing 6. (657 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (574 aa) | ||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) | ||||
SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) | ||||
RAD51AP1 | RAD51 associated protein 1. (366 aa) | ||||
FBH1 | F-box DNA helicase 1. (1045 aa) | ||||
SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) | ||||
NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (276 aa) | ||||
CHEK2 | Checkpoint kinase 2. (534 aa) |