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| | EAR24578.1 | Putative excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (819 aa) |
| | EAR23810.1 | Hypothetical protein. (337 aa) |
| | EAR23811.1 | Hypothetical protein; COG0613 Predicted metal-dependent phosphoesterases (PHP family). (286 aa) |
| | EAR23817.1 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (499 aa) |
| | EAR23821.1 | COG0210 Superfamily I DNA and RNA helicases. (1033 aa) |
| | deaD | ATP-dependent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (638 aa) |
| | dnaA | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (471 aa) |
| | EAR26163.1 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (381 aa) |
| | recF | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (387 aa) |
| | gyrB | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (664 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa) |
| | EAR26185.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | EAR26186.1 | Pyridoxine kinase. (196 aa) |
| | nucS | Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (231 aa) |
| | EAR26220.1 | Hypothetical protein; COG1054 Predicted sulfurtransferase; Belongs to the UPF0176 family. (295 aa) |
| | EAR26161.1 | Hypothetical protein; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (80 aa) |
| | EAR26228.1 | Hypothetical protein; COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase. (311 aa) |
| | EAR26280.1 | COG3680 Uncharacterized protein conserved in bacteria. (248 aa) |
| | EAR26281.1 | Hypothetical protein. (118 aa) |
| | EAR26282.1 | C-5 cytosine-specific DNA methylase family protein; COG0270 Site-specific DNA methylase. (352 aa) |
| | EAR26283.1 | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (1108 aa) |
| | EAR26286.1 | Hypothetical protein; COG0323 DNA mismatch repair enzyme (predicted ATPase). (509 aa) |
| | EAR26288.1 | Endonuclease; COG1158 Transcription termination factor. (1017 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | tadA | Cytosine/adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (479 aa) |
| | EAR24666.1 | Membrane protein. (110 aa) |
| | nusG | Transcription antitermination factor; Participates in transcription elongation, termination and antitermination. (315 aa) |
| | dnaX | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (713 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa) |
| | EAR24143.1 | COG1435 Thymidine kinase. (221 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (939 aa) |
| | EAR24159.1 | DNA polymerase III, delta prime subunit; COG0470 ATPase involved in DNA replication. (388 aa) |
| | EAR24168.1 | COG0566 rRNA methylases. (266 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (336 aa) |
| | EAR24177.1 | COG0708 Exonuclease III. (286 aa) |
| | EAR24180.1 | Hypothetical protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (538 aa) |
| | EAR24216.1 | Ribonucleotide-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (813 aa) |
| | EAR24218.1 | Ribonucleotide-diphosphate reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa) |
| | EAR24227.1 | COG1643 HrpA-like helicases. (1285 aa) |
| | rsmI | Tetrapyrrole methylase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (298 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (526 aa) |
| | EAR23797.1 | Sec-independent protein TadD; COG0084 Mg-dependent DNase. (307 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (276 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1202 aa) |
| | EAR24488.1 | Thermonuclease; COG1525 Micrococcal nuclease (thermonuclease) homologs. (183 aa) |
| | EAR24492.1 | COG0124 Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (430 aa) |
| | EAR24500.1 | Hypothetical protein; COG3593 Predicted ATP-dependent endonuclease of the OLD family. (635 aa) |
| | EAR24511.1 | COG3214 Uncharacterized protein conserved in bacteria. (410 aa) |
| | xseB | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (89 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (406 aa) |
| | EAR24537.1 | COG1322 Uncharacterized protein conserved in bacteria. (435 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (255 aa) |
| | EAR24285.1 | Restriction enzyme type I helicase subunits and related helicase; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1002 aa) |
| | EAR24286.1 | Hypothetical protein; COG0732 Restriction endonuclease S subunits. (395 aa) |
| | EAR24287.1 | COG0286 Type I restriction-modification system methyltransferase subunit. (507 aa) |
| | EAR24289.1 | DNA invertase; COG1961 Site-specific recombinases, DNA invertase Pin homologs. (203 aa) |
| | EAR24291.1 | COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains. (523 aa) |
| | EAR24295.1 | Integrase, putative; COG1961 Site-specific recombinases, DNA invertase Pin homologs. (480 aa) |
| | EAR24329.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (228 aa) |
| | ung | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (222 aa) |
| | EAR25063.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase. (553 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (760 aa) |
| | EAR25082.1 | COG0009 Putative translation factor (SUA5); Belongs to the SUA5 family. (218 aa) |
| | EAR25095.1 | COG2818 3-methyladenine DNA glycosylase. (196 aa) |
| | EAR25096.1 | methylated-DNA-protein-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (170 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (593 aa) |
| | nusA | Transcription elongation factor NusA; Participates in both transcription termination and antitermination. (333 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (167 aa) |
| | EAR25135.1 | COG1194 A/G-specific DNA glycosylase. (297 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (311 aa) |
| | EAR25158.1 | Putative 3-methyladenine DNA glycosylase; COG2169 Adenosine deaminase. (491 aa) |
| | EAR25163.1 | Hypothetical protein; COG1157 Flagellar biosynthesis/type III secretory pathway ATPase. (248 aa) |
| | EAR25166.1 | Hypothetical protein; COG2022 Uncharacterized enzyme of thiazole biosynthesis. (254 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (749 aa) |
| | rnj | Hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa) |
| | recA | Recombination repairing protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (386 aa) |
| | miaB | Hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (514 aa) |
| | miaA | tRNA isopentenyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (341 aa) |
| | lexA | SOS response regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (229 aa) |
| | EAR25218.1 | COG0566 rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (255 aa) |
| | pheS-2 | COG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (346 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (826 aa) |
| | EAR25233.1 | COG2094 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (195 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (451 aa) |
| | EAR25247.1 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (568 aa) |
| | EAR25249.1 | NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (210 aa) |
| | xerC | Tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (311 aa) |
| | EAR25254.1 | RNA pseudouridine synthase; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (257 aa) |
| | EAR25263.1 | Possible EA31 gene protein, phage lambda; COG1403 Restriction endonuclease. (282 aa) |
| | EAR25264.1 | Ea59 protein; COG3593 Predicted ATP-dependent endonuclease of the OLD family. (501 aa) |
| | EAR25265.1 | Hypothetical protein. (321 aa) |
| | EAR25270.1 | COG3593 Predicted ATP-dependent endonuclease of the OLD family. (668 aa) |
| | EAR25275.1 | Hypothetical protein. (414 aa) |
| | EAR25315.1 | Hypothetical protein. (50 aa) |
| | EAR25316.1 | Hypothetical protein. (102 aa) |
| | EAR25320.1 | Hypothetical protein; COG1533 DNA repair photolyase. (356 aa) |
| | EAR25327.1 | Hypothetical protein. (126 aa) |
| | rsmH | S-adenosyl-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (329 aa) |
| | EAR24039.1 | Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (301 aa) |
| | EAR24040.1 | COG0587 DNA polymerase III, alpha subunit. (1174 aa) |
| | EAR24063.1 | Putative excision nuclease ABC subunit; COG0178 Excinuclease ATPase subunit. (796 aa) |
| | EAR24087.1 | COG4581 Superfamily II RNA helicase. (810 aa) |
| | EAR24095.1 | SAM-dependent methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (328 aa) |
| | EAR24103.1 | Hypothetical protein. (239 aa) |
| | rnhA | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (173 aa) |
| | EAR24121.1 | Hypothetical protein. (272 aa) |
| | EAR24122.1 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. (494 aa) |
| | dnaE2 | DNA polymerase III subunit alpha; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1148 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (415 aa) |
| | EAR24344.1 | COG0566 rRNA methylases. (267 aa) |
| | EAR24349.1 | COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (232 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (640 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (957 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (690 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (879 aa) |
| | EAR24408.1 | Putative RNA-binding Sun protein; COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (454 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (309 aa) |
| | priA | Primosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (658 aa) |
| | rpoZ | DNA-directed RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (86 aa) |
| | nusB | Transcription termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (137 aa) |
| | EAR24433.1 | Hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (153 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (884 aa) |
| | EAR24438.1 | COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (472 aa) |
| | ruvB | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (343 aa) |
| | ruvA | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (205 aa) |
| | ruvC | Holliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (201 aa) |
| | thrS | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (653 aa) |
| | EAR24455.1 | COG0582 Integrase; Belongs to the 'phage' integrase family. (402 aa) |
| | EAR24457.1 | COG2963 Transposase and inactivated derivatives. (91 aa) |
| | EAR24458.1 | Transposase for IS3521; COG2801 Transposase and inactivated derivatives. (308 aa) |
| | EAR23671.1 | Hypothetical protein. (931 aa) |
| | EAR23672.1 | COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains. (517 aa) |
| | EAR23673.1 | COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); Belongs to the sigma-70 factor family. (244 aa) |
| | EAR23706.1 | Transposase. (464 aa) |
| | EAR23713.1 | Hypothetical protein; COG2963 Transposase and inactivated derivatives. (106 aa) |
| | EAR23715.1 | COG0582 Integrase; Belongs to the 'phage' integrase family. (333 aa) |
| | EAR23722.1 | Hypothetical protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (236 aa) |
| | EAR23725.1 | Hypothetical protein. (71 aa) |
| | EAR23726.1 | Hypothetical protein; COG1002 Type II restriction enzyme, methylase subunits. (570 aa) |
| | EAR23734.1 | COG0349 Ribonuclease D. (418 aa) |
| | EAR23746.1 | COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (819 aa) |
| | EAR23747.1 | DNA gyrase subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (692 aa) |
| | sigA | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (454 aa) |
| | EAR25349.1 | Hypothetical protein. (272 aa) |
| | EAR25371.1 | COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains. (558 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa) |
| | EAR25399.1 | Transcriptional regulator, NifR3/Smm1 family protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (388 aa) |
| | EAR25400.1 | Hypothetical protein. (159 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (461 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (242 aa) |
| | ybeY | Hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (153 aa) |
| | EAR25424.1 | Hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa) |
| | dnaJ | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (366 aa) |
| | EAR25435.1 | COG1466 DNA polymerase III, delta subunit. (347 aa) |
| | EAR25438.1 | Competence protein ComEA helix-hairpin-helix region; COG1555 DNA uptake protein and related DNA-binding proteins. (196 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (868 aa) |
| | EAR25485.1 | COG1530 Ribonucleases G and E. (944 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1096 aa) |
| | EAR25493.1 | COG1864 DNA/RNA endonuclease G, NUC1. (278 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (865 aa) |
| | EAR25531.1 | DNA glycosylase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (332 aa) |
| | EAR25572.1 | COG0629 Single-stranded DNA-binding protein. (156 aa) |
| | orn | Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (206 aa) |
| | EAR25590.1 | Hypothetical protein. (281 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (775 aa) |
| | EAR25611.1 | COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain. (375 aa) |
| | EAR25613.1 | Putative transcriptional regulator; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (159 aa) |
| | xerC-2 | Tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (302 aa) |
| | EAR25637.1 | Hypothetical protein; COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Belongs to the UPF0102 family. (118 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (211 aa) |
| | trmD | tRNA-(guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (228 aa) |
| | rimM | 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (188 aa) |
| | smc | Chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1191 aa) |
| | EAR23864.1 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (298 aa) |
| | rncS | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (233 aa) |
| | EAR23874.1 | Membrane protein; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (118 aa) |
| | EAR23884.1 | DNA methyltransferase; COG0742 N6-adenine-specific methylase. (194 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (454 aa) |
| | EAR24856.1 | 23S rRNA methyltransferase/RumA; COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (410 aa) |
| | EAR24884.1 | Hypothetical protein; COG1403 Restriction endonuclease. (165 aa) |
| | EAR24893.1 | COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (417 aa) |
| | EAR24916.1 | COG4941 Predicted RNA polymerase sigma factor containing a TPR repeat domain; Belongs to the sigma-70 factor family. (396 aa) |
| | EAR24920.1 | Hypothetical protein; COG0457 FOG: TPR repeat. (438 aa) |
| | EAR24924.1 | tRNA/rRNA methyltransferase protein; COG0566 rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (345 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa) |
| | EAR24940.1 | COG1329 Transcriptional regulators, similar to M. xanthus CarD. (160 aa) |
| | EAR24947.1 | Hypothetical protein; May play a role in the intracellular transport of hydrophobic ligands. (198 aa) |
| | EAR24952.1 | Putative MutT family protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. (312 aa) |
| | EAR24959.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (198 aa) |
| | EAR24966.1 | Hypothetical protein; COG0519 GMP synthase, PP-ATPase domain/subunit. (281 aa) |
| | EAR24996.1 | DNA-binding protein; COG3695 Predicted methylated DNA-protein cysteine methyltransferase. (103 aa) |
| | EAR25011.1 | Hypothetical protein. (239 aa) |
| | EAR25018.1 | COG0557 Exoribonuclease R. (477 aa) |
| | EAR25042.1 | Hypothetical protein; COG0500 SAM-dependent methyltransferases. (395 aa) |
| | tsaD | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (353 aa) |
| | EAR23654.1 | Hypothetical protein; COG0456 Acetyltransferases. (163 aa) |
| | EAR23655.1 | Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. (206 aa) |
| | EAR23656.1 | Hypothetical protein; COG0802 Predicted ATPase or kinase. (167 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (315 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (331 aa) |
| | rpoC | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1293 aa) |
| | rpoB | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) |
| | EAR25743.1 | Hypothetical protein; COG3569 Topoisomerase IB. (324 aa) |
| | EAR25745.1 | COG0513 Superfamily II DNA and RNA helicases. (552 aa) |
| | EAR25750.1 | DNA glycosylase; COG0266 Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (272 aa) |
| | EAR25751.1 | COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (142 aa) |
| | EAR25752.1 | COG0514 Superfamily II DNA helicase. (719 aa) |
| | radA | Alkylation damage DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (451 aa) |
| | lysS-2 | COG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (499 aa) |
| | tilS | Hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (340 aa) |
| | EAR25823.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (199 aa) |
| | EAR25835.1 | Putative helicase; COG0514 Superfamily II DNA helicase. (657 aa) |
| | EAR25844.1 | Probable 5'-nucleotidase precursor; COG2374 Predicted extracellular nuclease. (1422 aa) |
| | EAR25845.1 | Putative regulator; COG3327 Phenylacetic acid-responsive transcriptional repressor. (272 aa) |
| | EAR25862.1 | COG0513 Superfamily II DNA and RNA helicases. (757 aa) |
| | EAR25864.1 | Hypothetical protein. (382 aa) |
| | EAR25950.1 | tRNA/rRNA methyltransferase; COG0566 rRNA methylases. (210 aa) |
| | EAR25953.1 | COG2189 Adenine specific DNA methylase Mod; Belongs to the N(4)/N(6)-methyltransferase family. (286 aa) |
| | EAR25958.1 | COG0708 Exonuclease III. (278 aa) |
| | EAR25967.1 | Hypothetical protein; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (378 aa) |
| | EAR26010.1 | COG2214 DnaJ-class molecular chaperone. (322 aa) |
| | EAR26099.1 | Putative helicase; COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member. (432 aa) |
| | EAR26110.1 | COG0286 Type I restriction-modification system methyltransferase subunit. (522 aa) |
| | EAR26111.1 | Type I restriction-modification system specificity determinant; COG0732 Restriction endonuclease S subunits. (388 aa) |
| | EAR26112.1 | Type I restriction-modification system endonuclease; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1024 aa) |
| | EAR26116.1 | Hypothetical protein. (196 aa) |
| | EAR26124.1 | COG2801 Transposase and inactivated derivatives. (627 aa) |
| | EAR26141.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (462 aa) |
| | EAR26144.1 | COG0629 Single-stranded DNA-binding protein. (172 aa) |
| | EAR26146.1 | poly(A) polymerase; COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (474 aa) |
| | rsmG | Glucose-inhibited division protein B; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (211 aa) |
