(68 nodes) Histidine metabolism network (Lentisphaera araneosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hisB	COG0131 Imidazoleglycerol-phosphate dehydratase. (194 aa)
	EDM25147.1	Hypothetical protein. (261 aa)
	hisI	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (131 aa)
	EDM25497.1	COG3547 Transposase and inactivated derivatives. (325 aa)
	EDM29411.1	COG3547 Transposase and inactivated derivatives. (135 aa)
	EDM29410.1	Haem catalase/peroxidase; COG3547 Transposase and inactivated derivatives. (228 aa)
	EDM29368.1	COG3547 Transposase and inactivated derivatives. (432 aa)
	EDM29360.1	COG3547 Transposase and inactivated derivatives. (359 aa)
	EDM29358.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	EDM29338.1	COG3547 Transposase and inactivated derivatives. (164 aa)
	EDM29337.1	COG3547 Transposase and inactivated derivatives. (247 aa)
	EDM29335.1	COG3039 Transposase and inactivated derivatives, IS5 family. (489 aa)
	hisG	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (284 aa)
	EDM27633.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	hisE	COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (87 aa)
	EDM26398.1	COG3547 Transposase and inactivated derivatives. (269 aa)
	EDM25980.1	COG3547 Transposase and inactivated derivatives. (438 aa)
	EDM26702.1	COG3039 Transposase and inactivated derivatives, IS5 family. (490 aa)
	EDM26700.1	COG3547 Transposase and inactivated derivatives. (176 aa)
	EDM26685.1	Hypothetical protein. (475 aa)
	hisC-2	COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa)
	EDM29687.1	COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Belongs to the HisA/HisF family. (255 aa)
	EDM29683.1	Hypothetical protein. (275 aa)
	EDM29635.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	EDM29441.1	COG3547 Transposase and inactivated derivatives. (359 aa)
	EDM29432.1	COG3547 Transposase and inactivated derivatives. (432 aa)
	hisC	COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa)
	hisF	Imidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa)
	hisH	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa)
	EDM25802.1	Hypothetical protein; COG3547 Transposase and inactivated derivatives. (238 aa)
	EDM25767.1	Hypothetical protein; COG3741 N-formylglutamate amidohydrolase. (249 aa)
	EDM25755.1	Hypothetical protein. (98 aa)
	EDM28916.1	Hypothetical protein. (520 aa)
	EDM25740.1	COG3039 Transposase and inactivated derivatives, IS5 family. (270 aa)
	EDM25739.1	ISPg7, transposase. (153 aa)
	EDM28158.1	COG3547 Transposase and inactivated derivatives. (419 aa)
	EDM28114.1	COG3039 Transposase and inactivated derivatives, IS5 family. (489 aa)
	EDM28055.1	COG3547 Transposase and inactivated derivatives. (432 aa)
	EDM28018.1	COG3547 Transposase and inactivated derivatives. (227 aa)
	EDM28002.1	COG3547 Transposase and inactivated derivatives. (150 aa)
	EDM28001.1	Haem catalase/peroxidase; COG3547 Transposase and inactivated derivatives. (219 aa)
	EDM28468.1	COG3039 Transposase and inactivated derivatives, IS5 family. (489 aa)
	EDM28466.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	EDM28308.1	COG3039 Transposase and inactivated derivatives, IS5 family. (139 aa)
	EDM28307.1	COG3039 Transposase and inactivated derivatives, IS5 family. (261 aa)
	EDM28298.1	Putative mini-circle transposase for IS117; COG3547 Transposase and inactivated derivatives. (270 aa)
	EDM25080.1	COG3547 Transposase and inactivated derivatives. (332 aa)
	EDM25399.1	COG3547 Transposase and inactivated derivatives. (359 aa)
	EDM28665.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	EDM28663.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	hisD	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa)
	EDM25593.1	COG3547 Transposase and inactivated derivatives. (364 aa)
	EDM24977.1	COG3547 Transposase and inactivated derivatives. (359 aa)
	EDM25894.1	COG3547 Transposase and inactivated derivatives. (181 aa)
	EDM25893.1	COG3547 Transposase and inactivated derivatives. (229 aa)
	EDM25882.1	Hypothetical protein. (805 aa)
	EDM26964.1	COG3547 Transposase and inactivated derivatives. (432 aa)
	EDM26908.1	COG3039 Transposase and inactivated derivatives, IS5 family. (269 aa)
	EDM26907.1	Transposase, IS4; COG3039 Transposase and inactivated derivatives, IS5 family. (213 aa)
	EDM26505.1	COG3039 Transposase and inactivated derivatives, IS5 family. (490 aa)
	EDM24659.1	COG3039 Transposase and inactivated derivatives, IS5 family. (219 aa)
	EDM24706.1	COG3547 Transposase and inactivated derivatives. (269 aa)
	EDM25098.1	Glutamine amidotransferase, class-II; COG0121 Predicted glutamine amidotransferase. (257 aa)
	EDM26634.1	COG3547 Transposase and inactivated derivatives. (359 aa)
	EDM26551.1	COG3547 Transposase and inactivated derivatives. (415 aa)
	EDM26524.1	COG3547 Transposase and inactivated derivatives. (160 aa)
	EDM26523.1	Transposase, IS4; COG3039 Transposase and inactivated derivatives, IS5 family. (342 aa)
	EDM26522.1	Putative mini-circle transposase for IS117; COG3547 Transposase and inactivated derivatives. (256 aa)

Your Current Organism:

Lentisphaera araneosa

NCBI taxonomy Id: 313628
Other names: L. araneosa HTCC2155, Lentisphaera araneosa HTCC2155, Lentisphaera araneosa str. HTCC2155, Lentisphaera araneosa strain HTCC2155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDM24659.1	EDM25739.1	LNTAR_04271	LNTAR_13357	COG3039 Transposase and inactivated derivatives, IS5 family.	ISPg7, transposase.	0.922
EDM24659.1	EDM28308.1	LNTAR_04271	LNTAR_10346	COG3039 Transposase and inactivated derivatives, IS5 family.	COG3039 Transposase and inactivated derivatives, IS5 family.	0.928
EDM24706.1	EDM25593.1	LNTAR_03994	LNTAR_08221	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.561
EDM24706.1	EDM27633.1	LNTAR_03994	LNTAR_20543	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.561
EDM24706.1	EDM28466.1	LNTAR_03994	LNTAR_11136	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.565
EDM24706.1	EDM28663.1	LNTAR_03994	LNTAR_08839	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.561
EDM24706.1	EDM28665.1	LNTAR_03994	LNTAR_08849	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.561
EDM24706.1	EDM29358.1	LNTAR_03994	LNTAR_23249	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.560
EDM24706.1	EDM29635.1	LNTAR_03994	LNTAR_17833	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.561
EDM24977.1	EDM25593.1	LNTAR_07926	LNTAR_08221	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM25980.1	LNTAR_07926	LNTAR_19322	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.612
EDM24977.1	EDM27633.1	LNTAR_07926	LNTAR_20543	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM28001.1	LNTAR_07926	LNTAR_11631	COG3547 Transposase and inactivated derivatives.	Haem catalase/peroxidase; COG3547 Transposase and inactivated derivatives.	0.424
EDM24977.1	EDM28466.1	LNTAR_07926	LNTAR_11136	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM28663.1	LNTAR_07926	LNTAR_08839	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM28665.1	LNTAR_07926	LNTAR_08849	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM29358.1	LNTAR_07926	LNTAR_23249	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM24977.1	EDM29410.1	LNTAR_07926	LNTAR_23509	COG3547 Transposase and inactivated derivatives.	Haem catalase/peroxidase; COG3547 Transposase and inactivated derivatives.	0.428
EDM24977.1	EDM29635.1	LNTAR_07926	LNTAR_17833	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.639
EDM25399.1	EDM25593.1	LNTAR_09706	LNTAR_08221	COG3547 Transposase and inactivated derivatives.	COG3547 Transposase and inactivated derivatives.	0.626

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