STRINGSTRING
IO99_16650 IO99_16650 dxs dxs IO99_02245 IO99_02245 IO99_02250 IO99_02250 IO99_02650 IO99_02650 rsgA rsgA IO99_05490 IO99_05490 IO99_06740 IO99_06740 thiC thiC IO99_09310 IO99_09310 rsgA-2 rsgA-2 IO99_09770 IO99_09770 IO99_11195 IO99_11195 iscS iscS adk adk IO99_12660 IO99_12660 thiE thiE IO99_12725 IO99_12725 IO99_12730 IO99_12730 thiG thiG IO99_12740 IO99_12740 thiH thiH thiI thiI IO99_17445 IO99_17445 IO99_18210 IO99_18210 thiM thiM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IO99_16650MoeB; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (625 aa)
IO99_02245Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
IO99_02250Cytochrome O ubiquinol oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
IO99_02650Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
rsgARibosome small subunit-dependent GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (357 aa)
IO99_05490Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
IO99_06740Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (437 aa)
IO99_09310ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
rsgA-2Ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (287 aa)
IO99_09770Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
IO99_11195Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (402 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (220 aa)
IO99_12660Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
thiEHypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (213 aa)
IO99_12725Thiamine monophosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
IO99_12730Thiamine biosynthesis protein ThiH; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
IO99_12740Thiamine biosynthesis protein ThiF; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
thiHIn Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; in Thermotoga this enzyme has an extra C-terminal domain; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa)
IO99_17445Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
IO99_18210Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (277 aa)
Your Current Organism:
Clostridium sulfidigenes
NCBI taxonomy Id: 318464
Other names: C. sulfidigenes, Clostridium sulfidigenes Sallam and Steinbuchel 2009, DSM 18982, strain SGB2
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