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| | Dgeo_0373 | KEGG: dra:DR0381 hypothetical protein, ev=3e-37, 67% identity. (124 aa) |
| | Dgeo_0396 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (302 aa) |
| | Dgeo_0397 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | Dgeo_0398 | KEGG: dra:DR0170 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase, ev=3e-54, 69% identity; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: (1.8e-50); PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK: (1e-47). (163 aa) |
| | ctaB | Cytochrome c oxidase assembly factor, CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (312 aa) |
| | Dgeo_0409 | PFAM: cytochrome oxidase assembly: (2e-06); KEGG: dra:DR2617 cytochrome AA3-controlling protein CtaA, putative, ev=1e-133, 75% identity. (326 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (570 aa) |
| | Dgeo_0426 | PFAM: protein of unknown function DUF179: (9.1e-54); KEGG: dra:DR0357 putative transcriptional regulator, ev=6e-64, 66% identity; Belongs to the UPF0301 (AlgH) family. (176 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | Dgeo_0450 | TIGRFAM: tryptophanyl-tRNA synthetase: (1.5e-85); PFAM: aminoacyl-tRNA synthetase, class Ib: (3e-91); KEGG: dra:DR1093 tryptophanyl-tRNA synthetase, ev=1e-137, 74% identity. (342 aa) |
| | Dgeo_0452 | KEGG: dra:DR1456 ribose-phosphate pyrophosphokinase, ev=1e-156, 88% identity; TIGRFAM: ribose-phosphate pyrophosphokinase: (1.3e-120); PFAM: phosphoribosyltransferase: (2e-23). (355 aa) |
| | Dgeo_0466 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (445 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | rplY | Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (241 aa) |
| | sigA | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (532 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (202 aa) |
| | Dgeo_0498 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (5.1e-44); PFAM: glutamine amidotransferase class-I: (1.1e-52) Anthranilate synthase component I and chorismate binding protein: (2.7e-120) Anthranilate synthase component I-like: (1.5e-05); KEGG: dra:DR0196 anthranilate synthase, ev=0.0, 77% identity. (642 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (361 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (417 aa) |
| | pyrB | KEGG: dra:DR1109 aspartate carbamoyltransferase catalytic chain, ev=1e-149, 86% identity; TIGRFAM: aspartate carbamoyltransferase: (2.7e-112); PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region: (9.4e-27) aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain: (3.6e-50); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | Dgeo_0510 | KEGG: pca:Pcar_0661 hypothetical protein, ev=2e-77, 53% identity. (301 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: dra:DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase. (514 aa) |
| | folD1 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | rpmB | TIGRFAM: ribosomal protein L28: (3.3e-25); KEGG: dra:DR2524 50S ribosomal protein L28, ev=3e-31, 80% identity; Belongs to the bacterial ribosomal protein bL28 family. (84 aa) |
| | Dgeo_0536 | GTPase (G3E family); PFAM: cobalamin synthesis protein, P47K: (7.2e-66) cobalamin synthesis CobW-like: (2e-15); KEGG: bha:BH1790 hypothetical protein, ev=6e-69, 40% identity. (352 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (547 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase: (0); KEGG: dra:DR2174 leucyl-tRNA synthetase, ev=0.0, 81% identity; Belongs to the class-I aminoacyl-tRNA synthetase family. (819 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (497 aa) |
| | rpmI | PFAM: ribosomal protein L35: (2.6e-09); KEGG: dra:DR2005 50S ribosomal protein L35, ev=1e-24, 82% identity; Belongs to the bacterial ribosomal protein bL35 family. (67 aa) |
| | rplT | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | rpmE | Ribosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (72 aa) |
| | tdk | PFAM: thymidine kinase: (1.5e-63); KEGG: dra:DR1984 thymidine kinase, ev=1e-83, 77% identity. (219 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (505 aa) |
| | Dgeo_0606 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (1.8e-16) sigma-70 region 4: (4.3e-14) Sigma-70, region 4 type 2: (4.6e-13); KEGG: ttj:TTHB211 putative RNA polymerase sigma factor, ev=2e-27, 40% identity; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (370 aa) |
| | Dgeo_0632 | PFAM: TPR repeat: (0.44) Tetratricopeptide TPR_4: (0.002) Tetratricopeptide TPR_2: (0.0002); SMART: Tetratricopeptide region: (0.029); KEGG: dra:DR0937 tetratricopeptide repeat family protein, ev=1e-151, 54% identity. (541 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1537 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1152 aa) |
| | rplL | Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | rplJ | Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (169 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplK | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (190 aa) |
| | Dgeo_2324 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (403 aa) |
| | Dgeo_2315 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (392 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (216 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (242 aa) |
| | Dgeo_2274 | KEGG: bba:Bd2777 predicted hydrolase of HD superfamily, ev=5e-23, 41% identity. (193 aa) |
| | Dgeo_2269 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (2.2e-20) sigma-70 region 4: (1.1e-16) Sigma-70, region 4 type 2: (7.5e-19); KEGG: sco:SCO3892 putative RNA polymerase sigma factor, ev=3e-23, 43% identity; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI): (6.9e-40); KEGG: dra:DR0123 phosphoribosylanthranilate isomerase, ev=1e-67, 66% identity; Belongs to the TrpF family. (214 aa) |
| | Dgeo_2250 | TIGRFAM: ribosomal protein L28: (2e-24); KEGG: ttj:TTHA0042 50S ribosomal protein L28, ev=1e-14, 62% identity. (71 aa) |
| | cmk | KEGG: dra:DR2543 cytidylate kinase, ev=1e-79, 76% identity; TIGRFAM: cytidylate kinase: (8.9e-44); PFAM: cytidylate kinase region: (1.6e-31). (209 aa) |
| | rpmA | PFAM: ribosomal protein L27: (7.4e-49); KEGG: dra:DR0085 50S ribosomal protein L27, ev=8e-37, 83% identity; Belongs to the bacterial ribosomal protein bL27 family. (91 aa) |
| | rplU | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (99 aa) |
| | Dgeo_2213 | Nucleotide-diphospho-sugar transferase superfamily protein; KEGG: dra:DR2329 hypothetical protein, ev=8e-93, 69% identity. (264 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (885 aa) |
| | rpsO | Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (91 aa) |
| | glnS | glutaminyl-tRNA synthetase containing GatB/Yqey domain; KEGG: dra:DR2611 glutaminyl-tRNA synthetase, ev=0.0, 72% identity; TIGRFAM: glutaminyl-tRNA synthetase: (1.2e-218); PFAM: glutamyl-tRNA synthetase, class Ic: (1e-122) GatB/Yqey: (1.7e-34). (816 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa) |
| | Dgeo_2146 | KEGG: dra:DR2344 hypothetical protein, ev=1e-20, 41% identity. (178 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (737 aa) |
| | Dgeo_2131 | TIGRFAM: uroporphyrin-III C-methyltransferase: (9e-132); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (6.1e-80) Uroporphyrinogen III synthase HEM4: (1e-26); KEGG: dra:DRA0011 uroporphyrin-III synthase / uroporphyrin-III C-methyltransferase, ev=1e-147, 60% identity. (507 aa) |
| | Dgeo_2129 | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain: (1.4e-19); KEGG: cvi:CV0813 uroporphyrin-III C-methyltransferase, ev=2e-23, 46% identity. (188 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (365 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit: (0); PFAM: phosphoribosylglycinamide synthetase: (0.0013) protein of unknown function DUF201: (0.0017) Carbamoyl-phosphate synthase L chain, ATP-binding: (5.1e-23) Carbamoyl-phosphate synthetase large chain, oligomerisation: (2.8e-60) Carbamoyl-phosphate synthetase large chain-like: (1.3e-29); KEGG: dra:DR0668 carbamoyl-phosphate synthase large chain, ev=0.0, 89% identity. (1029 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit: (6.3e-239); PFAM: glutamine amidotransferase class-I: (1.9e-65) Carbamoyl-phosphate synthase, small chain: (1.3e-72); KEGG: dra:DR0684 carbamoyl-phosphate synthase small chain, ev=0.0, 95% identity; Belongs to the CarA family. (394 aa) |
| | pth | Aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (214 aa) |
| | atpE | V-type H+-ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa) |
| | atpC | V-type H+-ATPase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (325 aa) |
| | atpA | V-type H+-ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (582 aa) |
| | atpB | V-type H+-ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (470 aa) |
| | atpD | V-type H+-ATPase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (222 aa) |
| | Dgeo_2037 | DnaB-like protein helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (849 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (233 aa) |
| | Dgeo_2008 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (723 aa) |
| | Dgeo_1993 | ApaG-like protein; PFAM: ApaG: (5.6e-56); KEGG: dra:DR0228 ApaG protein, ev=9e-39, 58% identity. (130 aa) |
| | Dgeo_1984 | Glycosyl hydrolase family 98. (417 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | Dgeo_1979 | Epoxide Hydrolase; KEGG: dra:DR1803 hypothetical protein, ev=1e-36, 60% identity. (126 aa) |
| | Dgeo_1978 | Domain of unknown function DUF1730; PFAM: HEAT: (0.0045) 4Fe-4S ferredoxin, iron-sulfur binding: (0.00021) Domain of unknown function DUF1730: (6.9e-12); SMART: PBS lyase HEAT-like repeat: (3.8e-06); KEGG: tth:TTC0112 iron-sulfur cluster-binding protein, ev=5e-88, 51% identity. (397 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (481 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (925 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase: (4.9e-217); PFAM: aminotransferase class-III: (3.9e-73); KEGG: dra:DR0555 glutamate-1-semialdehyde 2,1-aminomutase, ev=0.0, 74% identity. (457 aa) |
| | Dgeo_1939 | TIGRFAM: thiamine pyrophosphokinase: (2.2e-45); PFAM: Thiamin pyrophosphokinase, catalytic region: (4.4e-27); KEGG: dra:DR0552 hypothetical protein, ev=4e-79, 74% identity. (212 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (609 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa) |
| | Dgeo_1922 | TIGRFAM: thiamine biosynthesis protein ThiS: (6.9e-21); PFAM: thiamineS: (2.5e-11); KEGG: dra:DRA0173 thiamin biosynthesis ThiS, ev=2e-20, 71% identity. (62 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (267 aa) |
| | Dgeo_1919 | KEGG: dra:DRA0171 phosphomethylpyrimidine kinase, ev=7e-88, 71% identity; TIGRFAM: Phosphomethylpyrimidine kinase type-2: (1.9e-103); PFAM: Phosphomethylpyrimidine kinase type-1: (4.6e-120). (254 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (587 aa) |
| | Dgeo_1903 | PFAM: 5-formyltetrahydrofolate cyclo-ligase: (5.4e-38); KEGG: dra:DR1815 hypothetical protein, ev=6e-57, 65% identity. (184 aa) |
| | Dgeo_1889 | KEGG: dra:DR0494 DNA topology modulation protein FlaR-related protein, ev=2e-53, 61% identity. (163 aa) |
| | Dgeo_1886 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (594 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa) |
| | rpsL | Ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (136 aa) |
| | rpsG | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (696 aa) |
| | Dgeo_1869 | TIGRFAM: translation elongation factor Tu: (3.1e-269) Small GTP-binding protein domain: (2.3e-10); PFAM: protein synthesis factor, GTP-binding: (6.7e-106) elongation factor Tu-like: (5e-61) elongation factor Tu, domain 2: (1.3e-26); KEGG: dra:DR2050 elongation factor EF-Tu, ev=0.0, 92% identity. (405 aa) |
| | rpsJ | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (107 aa) |
| | rplC | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (207 aa) |
| | rplD | Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (213 aa) |
| | rplW | Ribosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa) |
| | rplB | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rpsS | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (95 aa) |
| | rplV | Ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (139 aa) |
| | rpsC | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (248 aa) |
| | rplP | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa) |
| | rpmC | PFAM: ribosomal protein L29: (5.9e-22); KEGG: dra:DR0319 50S ribosomal protein L29, ev=1e-18, 75% identity; Belongs to the universal ribosomal protein uL29 family. (74 aa) |
| | rpsQ | Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (94 aa) |
| | rplN | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (134 aa) |
| | rplX | Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (115 aa) |
| | rplE | Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsZ | Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa) |
| | rplF | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (185 aa) |
| | rplR | Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (112 aa) |
| | rpsE | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (177 aa) |
| | rpmD | PFAM: ribosomal protein L30: (6.3e-12); KEGG: dra:DR2114 50S ribosomal protein L30, ev=3e-16, 72% identity. (62 aa) |
| | rplO | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (154 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (197 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (99 aa) |
| | rpmJ | PFAM: ribosomal protein L36: (4.6e-17); KEGG: dra:DR2124 50S ribosomal protein L36, ev=6e-14, 91% identity; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa) |
| | rpsK | Ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa) |
| | rpsD | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (331 aa) |
| | rplQ | PFAM: ribosomal protein L17: (1e-42); KEGG: dra:DR2129 50S ribosomal protein L17, ev=4e-55, 93% identity. (116 aa) |
| | Dgeo_1818 | KEGG: dra:DR0856 DNA polymerase III, epsilon subunit, putative, ev=4e-63, 68% identity; TIGRFAM: DNA polymerase III, epsilon subunit: (5e-07); PFAM: Exonuclease, RNase T and DNA polymerase III: (1.8e-39); SMART: Exonuclease: (7.9e-47). (180 aa) |
| | Dgeo_1809 | TIGRFAM: riboflavin biosynthesis protein RibF: (7.1e-81); PFAM: Riboflavin kinase / FAD synthetase: (9.8e-47); KEGG: dra:DR1008 riboflavin kinase / FMN adenylyltransferase, ev=1e-136, 79% identity; Belongs to the ribF family. (303 aa) |
| | Dgeo_1775 | PFAM: ribonucleotide reductase: (3.6e-32); KEGG: dra:DRB0109 ribonucleoside-diphosphate reductase beta chain, ev=1e-98, 56% identity. (319 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (706 aa) |
| | acsA | Acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | Dgeo_1750 | PFAM: AMP-dependent synthetase and ligase: (5.5e-117); KEGG: dra:DR0460 acetyl-CoA synthase, ev=0.0, 78% identity. (636 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (266 aa) |
| | rplS | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (158 aa) |
| | rpsI | PFAM: ribosomal protein S9: (2.5e-53); KEGG: dra:DR0175 30S ribosomal protein S9, ev=2e-64, 93% identity; Belongs to the universal ribosomal protein uS9 family. (131 aa) |
| | rplM | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | cysS | KEGG: dra:DR1670 cysteinyl-tRNA synthetase, ev=0.0, 75% identity; TIGRFAM: cysteinyl-tRNA synthetase: (1.3e-179); PFAM: cysteinyl-tRNA synthetase, class Ia: (4.2e-149); Belongs to the class-I aminoacyl-tRNA synthetase family. (497 aa) |
| | Dgeo_1710 | PFAM: Chlorite dismutase: (6.9e-82); KEGG: dra:DR1481 hypothetical protein, ev=1e-121, 84% identity. (248 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | Dgeo_1678 | P-loop ATPase; KEGG: dra:DR1870 hypothetical protein, ev=9e-89, 68% identity. (256 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa) |
| | lepA | Small GTP-binding protein domain; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (595 aa) |
| | purM | KEGG: dra:DR1394 phosphoribosylformylglycinamidine cyclo-ligase, ev=1e-158, 80% identity; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase: (1.4e-103); PFAM: AIR synthase related protein: (8.1e-43) AIR synthase related protein-like: (6.9e-35). (355 aa) |
| | Dgeo_1609 | PFAM: PHP-like: (6.9e-37); SMART: DNA polymerase X: (3.2e-07) Phosphoesterase PHP-like: (6.5e-09); KEGG: dra:DR0467 hypothetical DNA polymerase / putative histidinol phosphatase, ev=0.0, 64% identity. (572 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (333 aa) |
| | Dgeo_1588 | KEGG: dra:DR1376 hypoxanthine-guanine phosphoribosyltransferase, ev=5e-81, 84% identity; TIGRFAM: hypoxanthine phosphoribosyltransferase: (4.1e-101); PFAM: phosphoribosyltransferase: (8.8e-32); Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | Dgeo_1587 | PFAM: Indole-3-glycerol phosphate synthase: (3e-77); KEGG: dra:DR1426 indole-3-glycerol phosphate synthase, ev=1e-91, 71% identity; Belongs to the TrpC family. (262 aa) |
| | Dgeo_1586 | PFAM: beta-lactamase-like: (3.3e-10); KEGG: rba:RB11859 PhnP protein homolog-putative hydrolase, ev=4e-21, 34% identity. (267 aa) |
| | Dgeo_1577 | PFAM: RNA binding S1: (4.5e-24); KEGG: dra:DR1983 30S ribosomal protein S1, ev=0.0, 82% identity. (587 aa) |
| | rpmH | PFAM: ribosomal protein L34: (3.4e-21); KEGG: dra:DR2152 50S ribosomal protein L34, ev=3e-18, 91% identity; Belongs to the bacterial ribosomal protein bL34 family. (47 aa) |
| | Dgeo_1550 | PFAM: phosphoribosyltransferase: (2e-10); KEGG: dra:DR0878 adenine phosphoribosyltransferase, putative, ev=1e-72, 77% identity. (176 aa) |
| | Dgeo_1546 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. (190 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (480 aa) |
| | Dgeo_1536 | PFAM: transcriptional coactivator/pterin dehydratase: (1.2e-11); KEGG: nph:NP1766A homolog to 4A-hydroxytetrahydrobiopterin dehydratase, ev=1e-11, 37% identity. (118 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (393 aa) |
| | Dgeo_1519 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (4.1e-17) sigma-70 region 4: (9.5e-16) Sigma-70, region 4 type 2: (6.2e-19); KEGG: dra:DR0180 RNA polymerase sigma-E factor, ev=1e-81, 80% identity; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (204 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (649 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (567 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa) |
| | rpsP | PFAM: ribosomal protein S16: (1.1e-33); KEGG: dra:DR1294 30S ribosomal protein S16, ev=3e-33, 78% identity; Belongs to the bacterial ribosomal protein bS16 family. (82 aa) |
| | Dgeo_1473 | Lea76/Lea29-like desiccation resistance protein; PFAM: Late embryogenesis abundant protein: (4.5e-09); KEGG: dra:DR1172 hypothetical protein, ev=2e-56, 51% identity. (236 aa) |
| | Dgeo_1453 | Translation elongation factor 2 (EF-2/EF-G); TIGRFAM: Small GTP-binding protein domain: (8.4e-18); PFAM: elongation factor G-like: (5.8e-30) protein synthesis factor, GTP-binding: (2.8e-45) elongation factor Tu, domain 2: (1.2e-10) elongation factor G, domain IV: (1.3e-54); KEGG: dra:DR0393 elongation factor EF-G, ev=0.0, 74% identity. (677 aa) |
| | rpsT | Ribosomal protein S20; Binds directly to 16S ribosomal RNA. (95 aa) |
| | Dgeo_1423 | Fibronectin-binding A-like protein; PFAM: protein of unknown function DUF814: (1e-40) Fibronectin-binding A-like: (4.5e-87); KEGG: dra:DR0559 fibronectin/fibrinogen-binding protein, putative, ev=0.0, 74% identity. (517 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | pyrF | TIGRFAM: Orotidine 5'-phosphate decarboxylase subfamily 2: (7.9e-123); PFAM: Orotidine 5'-phosphate decarboxylase: (3.3e-39); KEGG: dra:DR2200 orotidine-5'-phosphate decarboxylase, ev=1e-118, 81% identity; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (427 aa) |
| | Dgeo_1352 | PFAM: Amidase: (8.8e-66); KEGG: dra:DR1377 amidase, putative, ev=1e-158, 73% identity. (395 aa) |
| | purD | KEGG: dra:DR1431 phosphoribosylamine--glycine ligase, ev=1e-174, 74% identity; TIGRFAM: phosphoribosylamine--glycine ligase: (5.4e-166); PFAM: phosphoribosylglycinamide synthetase: (1e-95); Belongs to the GARS family. (417 aa) |
| | Dgeo_1346 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (403 aa) |
| | Dgeo_1333 | PFAM: Amidase: (1.7e-97); KEGG: dra:DR1625 amidase, putative, ev=1e-176, 68% identity. (468 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (288 aa) |
| | Dgeo_1325 | Nicotinate phosphoribosyltransferase related protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa) |
| | comB | PFAM: 2-phosphosulfolactate phosphatase: (1.9e-79); KEGG: dra:DR1400 putative 2-phosphosulfolactate phosphatase, ev=6e-81, 67% identity; Belongs to the ComB family. (241 aa) |
| | Dgeo_1317 | TIGRFAM: carboxynorspermidine decarboxylase: (9.3e-283); PFAM: Orn/DAP/Arg decarboxylase 2: (4.9e-29); KEGG: dra:DR1410 carboxynorspermidine decarboxylase, ev=0.0, 85% identity. (408 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (601 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (395 aa) |
| | Dgeo_1201 | PFAM: phosphoesterase, DHHA1: (1.2e-05) Threonyl/alanyl tRNA synthetase, SAD: (2.6e-08); KEGG: dra:DR0502 alanyl-tRNA synthetase-related protein, ev=1e-129, 63% identity. (399 aa) |
| | Dgeo_1177 | PFAM: aminotransferase class-III: (1.6e-89); KEGG: dra:DRA0121 aminotransferase, class III, ev=1e-179, 74% identity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | Dgeo_1163 | KEGG: tth:TTC0621 nicotinate-nucleotide pyrophosphorylase [carboxylating], ev=1e-72, 58% identity; TIGRFAM: nicotinate-nucleotide pyrophosphorylase: (2.2e-120); PFAM: Quinolinate phosphoribosyl transferase: (7.7e-72); Belongs to the NadC/ModD family. (278 aa) |
| | Dgeo_1162 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (512 aa) |
| | Dgeo_1141 | Gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03; PFAM: gamma-glutamyltranspeptidase: (7.6e-212); KEGG: dra:DR1524 gamma-glutamyltranspeptidase, ev=0.0, 81% identity. (531 aa) |
| | asnS | TIGRFAM: asparaginyl-tRNA synthetase: (6.2e-181); PFAM: tRNA synthetase, class II (D, K and N): (3.6e-77) nucleic acid binding, OB-fold, tRNA/helicase-type: (2.1e-18); KEGG: dra:DR1270 asparaginyl-tRNA synthetase, ev=0.0, 83% identity. (449 aa) |
| | aspS-2 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (577 aa) |
| | hisS | KEGG: dra:DR1349 histidyl-tRNA synthetase, ev=1e-174, 72% identity; TIGRFAM: histidyl-tRNA synthetase: (2e-105); PFAM: tRNA synthetase, class II (G, H, P and S): (1.9e-41) Anticodon-binding: (7.6e-11). (431 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (425 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1091 aa) |
| | rpsB | PFAM: ribosomal protein S2: (8.9e-93); KEGG: dra:DR1513 30S ribosomal protein S2, ev=1e-131, 89% identity; Belongs to the universal ribosomal protein uS2 family. (264 aa) |
| | tsf | Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (269 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (257 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (183 aa) |
| | argS | KEGG: dra:DR2568 arginyl-tRNA synthetase, ev=0.0, 84% identity; TIGRFAM: arginyl-tRNA synthetase: (1.2e-96). (628 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa) |
| | gluQ | glutamyl-tRNA synthetase, class Ic; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (303 aa) |
| | Dgeo_0999 | PFAM: Saccharopine dehydrogenase: (3.4e-175); KEGG: dra:DR1252 hypothetical protein, ev=0.0, 80% identity. (405 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | Dgeo_0985 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (2.8e-86); PFAM: glutamine amidotransferase class-I: (4.1e-79); KEGG: dra:DR1766 anthranilate synthase component II, ev=2e-86, 77% identity. (213 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | Dgeo_0947 | PFAM: bifunctional deaminase-reductase-like: (7.2e-33); KEGG: bce:BC3158 pyrimidine reductase, ev=5e-56, 56% identity. (180 aa) |
| | queA | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (437 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | lysS | TIGRFAM: lysyl-tRNA synthetase: (7.4e-180); PFAM: tRNA synthetase, class II (D, K and N): (9.4e-128) nucleic acid binding, OB-fold, tRNA/helicase-type: (6.3e-18); KEGG: dra:DR0372 lysyl-tRNA synthetase, ev=0.0, 83% identity; Belongs to the class-II aminoacyl-tRNA synthetase family. (512 aa) |
| | Dgeo_0902 | PFAM: transcription elongation factor GreA/GreB region: (2.7e-08); KEGG: dra:DR1970 transcription elongation factor, ev=2e-64, 79% identity; Belongs to the GreA/GreB family. (162 aa) |
| | Dgeo_0882 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase: (2.8e-187); KEGG: dra:DR2160 delta-aminolevulinic acid dehydratase, ev=1e-137, 75% identity; Belongs to the ALAD family. (327 aa) |
| | Dgeo_0864 | TIGRFAM: Small GTP-binding protein domain: (3.4e-21) GTP-binding protein TypA: (0); PFAM: elongation factor G-like: (4.5e-28) protein synthesis factor, GTP-binding: (2.5e-67) elongation factor Tu, domain 2: (1.1e-15); KEGG: dra:DR1198 GTP-binding elongation factor family protein TypA/BipA, ev=0.0, 91% identity. (593 aa) |
| | Dgeo_0847 | PFAM: phosphoribosyltransferase: (2e-05); KEGG: dra:DR0568 adenine phosphoribosyltransferase, ev=2e-75, 81% identity. (286 aa) |
| | rpmG | PFAM: ribosomal protein L33: (2.5e-18); KEGG: dra:DR2049 50S ribosomal protein L33, ev=3e-23, 92% identity; Belongs to the bacterial ribosomal protein bL33 family. (55 aa) |
| | Dgeo_0101 | PFAM: deoxynucleoside kinase: (1.2e-39); KEGG: dra:DR0298 deoxyguanosine kinase/deoxyadenosine kinase subunit, ev=2e-99, 83% identity. (207 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | Dgeo_0083 | KEGG: dra:DR0340 folylpolyglutamate synthase / dihydrofolate synthase, ev=1e-157, 73% identity; TIGRFAM: FolC bifunctional protein: (1.5e-116); PFAM: cytoplasmic peptidoglycan synthetases-like: (2.6e-06) Mur ligase, middle region: (8.4e-05). (404 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (371 aa) |
| | purC | KEGG: dra:DR0226 phosphoribosylaminoimidazole-succinocarboxamide synthase, ev=1e-108, 82% identity; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase: (1.5e-104); PFAM: SAICAR synthetase: (8.2e-90). (241 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (85 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (746 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | Dgeo_0057 | 7-keto-8-aminopelargonate synthetase-like enzyme; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (396 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. (703 aa) |
| | Dgeo_0036 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase: (4.5e-55); KEGG: dra:DR2535 hydrolase, putative, ev=1e-152, 86% identity. (294 aa) |
| | Dgeo_0034 | Agmatine deiminase; PFAM: Porphyromonas-type peptidyl-arginine deiminase: (2.5e-180); KEGG: dra:DR2359 hypothetical protein, ev=1e-154, 72% identity; Belongs to the agmatine deiminase family. (343 aa) |
| | rpmF | TIGRFAM: ribosomal protein L32: (3.4e-34); PFAM: ribosomal L32p protein: (1.5e-31); KEGG: dra:DR2366 50S ribosomal protein L32, ev=2e-28, 91% identity; Belongs to the bacterial ribosomal protein bL32 family. (60 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (413 aa) |
| | Dgeo_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (360 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (219 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (143 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (439 aa) |
| | Dgeo_0786 | PFAM: t-RNA-binding region: (5.7e-07); KEGG: rsp:RSP_3365 protein secretion chaperonine, ev=2e-18, 46% identity. (119 aa) |
| | hisZ | ATP phosphoribosyltransferase, Histidyl-tRNA synthetase-like protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (395 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (483 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (670 aa) |
| | Dgeo_0702 | P-loop ATPase, FlaR-like protein; KEGG: dra:DR0202 hypothetical protein, ev=2e-17, 43% identity. (87 aa) |
| | folD2 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (169 aa) |
| | Dgeo_0688 | TIGRFAM: adenylosuccinate lyase: (2.6e-179); PFAM: fumarate lyase: (2e-49); KEGG: dra:DR2178 adenylosuccinate lyase, ev=0.0, 86% identity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | Dgeo_0674 | PFAM: RNA binding S1: (3.6e-22); KEGG: dra:DR1754 hypothetical protein, ev=8e-58, 89% identity. (127 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (296 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa) |
| | Dgeo_0666 | TIGRFAM: ATP: (4.1e-106); PFAM: cobalamin adenosyltransferase: (8.8e-91); KEGG: dra:DR1638 hypothetical protein, ev=1e-78, 77% identity; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | tuf1 | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (405 aa) |
| | Dgeo_0102 | PFAM: deoxynucleoside kinase: (8.5e-18); KEGG: dra:DR0299 deoxyguanosine kinase/deoxyadenosine kinase subunit, ev=2e-74, 72% identity. (205 aa) |
| | Dgeo_0133 | Metal dependent phosphohydrolase; KEGG: dra:DR2582 hypothetical protein, ev=9e-71, 74% identity; TIGRFAM: conserved hypothetical protein: (9.5e-30); PFAM: metal-dependent phosphohydrolase, HD subdomain: (1.6e-20); SMART: Metal-dependent phosphohydrolase, HD region: (4.4e-14). (204 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (278 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (199 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (299 aa) |
| | rplI | Ribosomal protein L9; Binds to the 23S rRNA. (146 aa) |
| | rpsR | Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (91 aa) |
| | rpsF | Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (102 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (380 aa) |
| | Dgeo_0198 | GTPase, G3E family; PFAM: cobalamin synthesis protein, P47K: (7.5e-65) cobalamin synthesis CobW-like: (1.8e-29); KEGG: dra:DR2408 CobW protein, putative, ev=1e-140, 80% identity. (322 aa) |
| | udk | TIGRFAM: uridine kinase: (8.6e-102); PFAM: phosphoribulokinase/uridine kinase: (5.1e-47); KEGG: dra:DR0159 uridine kinase, ev=3e-98, 90% identity. (204 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (404 aa) |
| | folE | PFAM: GTP cyclohydrolase I: (1.7e-55); KEGG: dra:DR0036 GTP cyclohydrolase I, ev=2e-82, 80% identity. (202 aa) |
| | pheS | KEGG: dra:DR2354 phenylalanyl-tRNA synthetase alpha chain, ev=1e-172, 85% identity; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit: (6e-98); PFAM: phenylalanyl-tRNA synthetase, class IIc: (6.9e-142) aminoacyl tRNA synthetase, class II-like: (1.2e-27); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | pheT | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit: (8.1e-157); KEGG: dra:DR2357 phenylalanyl-tRNA synthetase beta chain, ev=0.0, 73% identity. (819 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (99 aa) |
| | Dgeo_0255 | KEGG: dra:DR0507 DNA polymerase III alpha subunit, ev=0.0, 85% identity; TIGRFAM: DNA polymerase III, alpha subunit: (0); PFAM: PHP-like: (3e-72) nucleic acid binding, OB-fold, tRNA/helicase-type: (8.5e-09); SMART: Phosphoesterase PHP-like: (5.5e-27). (1322 aa) |
| | Dgeo_0268 | Nitric-oxide synthase; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (375 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (841 aa) |
| | Dgeo_0274 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein: (3.5e-12); KEGG: dra:DR2241 hypothetical protein, ev=1e-137, 54% identity. (479 aa) |
| | coaD | Phosphopantetheine adenylyltransferase, CoaD; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (184 aa) |
| | Dgeo_0300 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (383 aa) |
| | Dgeo_0301 | TIGRFAM: riboflavin synthase, alpha subunit: (2.4e-59); PFAM: Lumazine-binding protein: (6.1e-25); KEGG: dra:DR0154 riboflavin synthase alpha chain, ev=2e-79, 68% identity. (214 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (388 aa) |
| | Dgeo_0333 | TIGRFAM: FolC bifunctional protein: (1.6e-122); PFAM: cytoplasmic peptidoglycan synthetases-like: (3.7e-11) Mur ligase, middle region: (1.7e-08); KEGG: dra:DR2575 folyl-polyglutamate synthetase, ev=1e-126, 69% identity; Belongs to the folylpolyglutamate synthase family. (414 aa) |
| | Dgeo_0341 | Mannose-6-phosphate isomerase, type 2; PFAM: Nucleotidyl transferase: (3.2e-70); KEGG: dra:DRA0032 mannose-1-phosphate guanylyltransferase, ev=1e-157, 76% identity. (359 aa) |
| | Dgeo_0352 | PFAM: phosphoglucomutase/phosphomannomutase C terminal: (1.7e-05) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I: (1.2e-44) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II: (2.2e-07) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III: (1.4e-07); KEGG: dra:DRA0047 phosphomannomutase, ev=0.0, 78% identity. (475 aa) |
| | Dgeo_0363 | KEGG: dra:DR0268 putative sulfonate/nitrate/taurine transport system substrate-binding protein, ev=1e-129, 73% identity. (317 aa) |
| | Dgeo_0372 | PFAM: protein of unknown function DUF165: (2.1e-05); KEGG: dra:DR0380 hypothetical protein, ev=3e-67, 78% identity. (181 aa) |
