STRINGSTRING
lpxA lpxA fabZ fabZ uppS uppS ACA98139.1 ACA98139.1 ACA98254.1 ACA98254.1 ACA98300.1 ACA98300.1 accD accD accB accB ACA98051.1 ACA98051.1 lpxC lpxC lpxB-2 lpxB-2 ispH ispH fabH fabH plsX plsX crtQ crtQ lpxB lpxB ACA98540.1 ACA98540.1 sdsA sdsA ACA98605.1 ACA98605.1 ACA98629.1 ACA98629.1 fadD fadD ispG ispG ACA98768.1 ACA98768.1 lipA lipA dxr dxr wcaG wcaG pgsA pgsA plsC plsC lpxD lpxD fabB fabB plsY plsY fabF fabF acpP acpP ACA99080.1 ACA99080.1 crtE crtE ACA99104.1 ACA99104.1 fni fni ispF ispF dxs dxs ACA99172.1 ACA99172.1 ACA99196.1 ACA99196.1 crtU crtU menE menE ACA99416.1 ACA99416.1 ACA99491.1 ACA99491.1 ACA99531.1 ACA99531.1 lipA-2 lipA-2 ACA99613.1 ACA99613.1 ACA99649.1 ACA99649.1 envM envM dgk dgk ACA99757.1 ACA99757.1 crtH crtH ACA99891.1 ACA99891.1 ispD ispD crtP crtP crtB crtB acs acs ACB00060.1 ACB00060.1 accC accC ACB00171.1 ACB00171.1 ACB00181.1 ACB00181.1 fabG fabG plsC-2 plsC-2 ispE ispE ACB00404.1 ACB00404.1 tagO tagO accA accA rfaG rfaG cdsA cdsA ACB00496.1 ACB00496.1 fabD fabD murG murG glmU glmU desA desA gpsA gpsA ACB00830.1 ACB00830.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (155 aa)
uppSUndecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (245 aa)
ACA98139.1Conserved hypothetical protein with saccharopine dehydrogenase/reductase domain; Similar to sll1601 of Synechocystis sp. PCC 6803. (409 aa)
ACA98254.1Conserved membrane protein; Similar to sll0727 of Synechocystis sp. PCC 6803 and all4125 of Nostoc sp. PCC 7120. (570 aa)
ACA98300.1Dolichyl-phosphate-mannose-protein mannosyltransferase family; Similar to all2870 of Nostoc sp. PCC 7120. (593 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (319 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (165 aa)
ACA98051.1Inositol monophosphatase family; Similar to sll0895 of Synechocystis sp. PCC 6803. (281 aa)
lpxCUDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (275 aa)
lpxB-2Lipid A disaccharide synthetase; Similar to slr1677 of Synechocystis sp. PCC 6803. (420 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (403 aa)
fabHBeta-ketoacyl-acyl carrier protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (334 aa)
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (365 aa)
crtQZeta-carotene desaturase; Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'. (487 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (390 aa)
ACA98540.1Glycosyl transferase, group 2 family protein; Similar to sll137 of Synechocystis sp. PCC 6803. (474 aa)
sdsASolanesyl diphosphate synthase; Similar to slr0611 of Synechocystis sp. PCC 6803; Belongs to the FPP/GGPP synthase family. (323 aa)
ACA98605.1Conserved hypothetical protein; Similar to FTT0395 of Francisella tularensis subsp. tularensis SCHU S4. (235 aa)
ACA98629.1Inositol-1-monophosphatase family protein; Similar to gene sll1383 of Synechocystis sp. PCC 6803; Belongs to the inositol monophosphatase superfamily. (280 aa)
fadDLong-chain-fatty-acid CoA ligase (AMP-forming); Similar to gene slr1609 of Synechocystis sp. PCC6803. (647 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (406 aa)
ACA98768.1Hydrolase, alpha/beta fold family; Similar to slr0264 of Synechocystis sp. PCC 6803. (360 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (301 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa)
wcaGNAD dependent epimerase/dehydratase family protein; Similar to gene SYNW0052 of Synechococcus sp. WH 8102. (400 aa)
pgsACDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Similar to gene sll1522 of Synechocystis sp. strain PCC 6803; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (178 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase; Similar to slr2103 of Synechocystis sp. PCC 6803. (291 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
fabB3-oxoacyl-[acyl-carrier-protein] synthase; Similar to slr1332 in Synechocystis sp. PCC 6803; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (378 aa)
plsYConserved, predicted membrane protein (DUF205); Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (215 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (418 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (81 aa)
ACA99080.1Conserved hypothetical membrane protein; Similar to sll0727 in Synechocystis sp. PCC 6803. (560 aa)
crtEGeranylgeranyl pyrophosphate synthase; Similar to slr0739 in Synechocystis sp. PCC 6803; Belongs to the FPP/GGPP synthase family. (302 aa)
ACA99104.1Acyltransferase domain protein; Similar to slr2060 in Synechocystis sp. PCC 6803. (396 aa)
fniIsopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (342 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa)
ACA99172.1Polyketide synthase. (2720 aa)
ACA99196.1NnrU protein; Similar to slr1599 of Synechocystis sp. PCC 6803. (238 aa)
crtUBeta-carotene desaturase; Similar to sll0254 of Synechocystis sp. PCC 6803. (645 aa)
menEO-succinylbenzoyl-CoA synthetase; Similar to slr0492 in Synechocystis sp. PCC 6803. (385 aa)
ACA99416.1Lignostilbene-alpha,beta-dioxygenase; Similar to sll1541 in Synechocystis sp. PCC 6803. (492 aa)
ACA99491.1Uncharacterized protein involved in exopolysaccharide biosynthesis; Similar to sll0923 in Synechocystis sp. PCC 6803. (756 aa)
ACA99531.1Conserved hypothetical protein; Similar to alr1242 in Nostoc sp. PCC 7120. (222 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (300 aa)
ACA99613.1FAD dependent oxidoreductase; Similar to slr1293 of Synechocystis sp. PCC 6803. (499 aa)
ACA99649.1Conserved hypothetical protein; Similar to tlr1675 of Thermosynechococcus elongatus BP-1. (153 aa)
envMEnoyl-[acyl-carrier-protein] reductase; Similar to slr1051 in Synechocystis sp. PCC 6803. (258 aa)
dgkDiacylglycerol kinase; Similar to all0270 of Nostoc sp. PCC 7120. (162 aa)
ACA99757.1FAD dependent oxidoreductase; Similar to sll0033 of Synechocystis sp. PCC 6803. (513 aa)
crtHCarotenoid cis-trans isomerase; Similar to sll0033 of Synechocystis sp. PCC 6803. (513 aa)
ACA99891.1Heptosyltransferase family protein; Similar to alr5168 of Nostoc sp. PCC 7120. (319 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (232 aa)
crtPPhytoene dehydrogenase; Similar to slr1254 of Synechocystis sp. PCC 6803. (471 aa)
crtBPhytoene synthase; Similar to slr1255 of Synechocystis sp. PCC 6803. (313 aa)
acsacetyl-CoA synthetase; Similar to all0769 of Nostoc sp. PCC 7120. (915 aa)
ACB00060.1Conserved hypothetical protein (TIGR00147); Similar to all1876 of Nostoc sp. PCC 7120. (311 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
ACB00171.1Putative zinc-binding oxidoreductase; Similar to alr2948 of Nostoc sp. PCC 7120. (333 aa)
ACB00181.1Retinal pigment epithelial membrane protein; Similar to all4895 of Nostoc sp. PCC 7120. (484 aa)
fabG3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
plsC-21-acyl-sn-glycerol-3-phosphate acyltransferase; Similar to alr0241 of Nostoc sp. strain PCC 7120; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (217 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (316 aa)
ACB00404.1Tetratricopeptide repeat domain protein; Similar to alr5340 of Nostoc sp. PCC 7120. (376 aa)
tagOUDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; Similar to sll0648 of Synechocystis sp. PCC 6803. (353 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
rfaGGlycosyl transferase; Similar to sll0380 of Synechocystis sp. PCC 6803. (360 aa)
cdsAPhosphatidate cytidylyltransferase; Similar to slr1369 of Synechocystis sp. PCC 6803; Belongs to the CDS family. (292 aa)
ACB00496.1Hypothetical membrane protein. (69 aa)
fabDMalonyl CoA-acyl carrier protein transacylase; Similar to slr2023 of Synechocystis sp. PCC 6803. (292 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (353 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (449 aa)
desAPhosphatidylcholine desaturase. (347 aa)
gpsANAD+ dependent glycerol-3-phosphate dehydrogenase; Similar to slr1755 of Synechocystis sp. PCC 6803; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (340 aa)
ACB00830.1Conserved hypothetical protein (DUF608); Similar to sll1775 of Synechocystis sp. PCC 6803. (803 aa)
Your Current Organism:
Synechococcus sp. PCC7002
NCBI taxonomy Id: 32049
Other names: Agmenellum quadruplicatum, Agmenellum quadruplicatum PR-6, S. sp. PCC 7002, Synechococcus PCC7002 PR-6, Synechococcus sp. (ATCC 27264), Synechococcus sp. (PCC 7002), Synechococcus sp. (strain PCC 7002), Synechococcus sp. PCC 7002
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