(18 nodes) Mismatch repair network (Ruminococcus torques)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	pcrA	ATP-dependent DNA helicase pcrA. (768 aa)
	yjcD	Putative ATP-dependent DNA helicase yjcD. (609 aa)
	CUQ82494.1	DNA polymerase III subunit delta. (345 aa)
	dnaX_1	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (530 aa)
	dnaN	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (369 aa)
	polC_2	DNA polymerase III polC-type. (231 aa)
	recJ	Single-stranded-DNA-specific exonuclease recJ. (574 aa)
	ssb_2	Helix-destabilizing protein. (132 aa)
	helD	Helicase IV. (689 aa)
	mutS	DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (888 aa)
	mutL	DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (708 aa)
	xseB	Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (74 aa)
	xseA	Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (410 aa)
	ligA	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (652 aa)
	dnaE	DNA polymerase III subunit alpha. (1157 aa)
	mutS2	MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (791 aa)
	ssbB	Single-stranded DNA-binding protein ssbB. (148 aa)
	dnaX_2	DNA polymerase III subunit tau. (331 aa)

Your Current Organism:

Ruminococcus torques

NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUQ82494.1	dnaE	ERS852502_00526	ERS852502_02681	DNA polymerase III subunit delta.	DNA polymerase III subunit alpha.	0.992
CUQ82494.1	dnaN	ERS852502_00526	ERS852502_00775	DNA polymerase III subunit delta.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.994
CUQ82494.1	dnaX_1	ERS852502_00526	ERS852502_00731	DNA polymerase III subunit delta.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.988
CUQ82494.1	dnaX_2	ERS852502_00526	ERS852502_02801	DNA polymerase III subunit delta.	DNA polymerase III subunit tau.	0.987
CUQ82494.1	mutL	ERS852502_00526	ERS852502_01708	DNA polymerase III subunit delta.	DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.424
CUQ82494.1	polC_2	ERS852502_00526	ERS852502_00888	DNA polymerase III subunit delta.	DNA polymerase III polC-type.	0.916
dnaE	CUQ82494.1	ERS852502_02681	ERS852502_00526	DNA polymerase III subunit alpha.	DNA polymerase III subunit delta.	0.992
dnaE	dnaN	ERS852502_02681	ERS852502_00775	DNA polymerase III subunit alpha.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.993
dnaE	dnaX_1	ERS852502_02681	ERS852502_00731	DNA polymerase III subunit alpha.	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.988
dnaE	dnaX_2	ERS852502_02681	ERS852502_02801	DNA polymerase III subunit alpha.	DNA polymerase III subunit tau.	0.987
dnaE	pcrA	ERS852502_02681	ERS852502_00128	DNA polymerase III subunit alpha.	ATP-dependent DNA helicase pcrA.	0.479
dnaE	polC_2	ERS852502_02681	ERS852502_00888	DNA polymerase III subunit alpha.	DNA polymerase III polC-type.	0.916
dnaE	ssbB	ERS852502_02681	ERS852502_02718	DNA polymerase III subunit alpha.	Single-stranded DNA-binding protein ssbB.	0.721
dnaE	ssb_2	ERS852502_02681	ERS852502_01395	DNA polymerase III subunit alpha.	Helix-destabilizing protein.	0.721
dnaE	yjcD	ERS852502_02681	ERS852502_00265	DNA polymerase III subunit alpha.	Putative ATP-dependent DNA helicase yjcD.	0.460
dnaN	CUQ82494.1	ERS852502_00775	ERS852502_00526	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III subunit delta.	0.994
dnaN	dnaE	ERS852502_00775	ERS852502_02681	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III subunit alpha.	0.993
dnaN	dnaX_1	ERS852502_00775	ERS852502_00731	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.992
dnaN	dnaX_2	ERS852502_00775	ERS852502_02801	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III subunit tau.	0.989
dnaN	mutL	ERS852502_00775	ERS852502_01708	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.938