(33 nodes) Response to amine network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RGS7	Regulator of G protein signaling 7. (487 aa)
	ASS1	Argininosuccinate synthase 1. (391 aa)
	TRDMT1	tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (391 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1507 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	EDN1	Endothelin 1. (211 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	ASIC1	Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (574 aa)
	ARG1	Arginase. (322 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (669 aa)
	DBH	Dopamine beta-hydroxylase. (620 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
	ENSCANP00000038566	Uncharacterized protein. (400 aa)
	KCNC3	Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (428 aa)
	PDE1B	Phosphodiesterase. (536 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (651 aa)
	KCNC2	Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
	TH	Tyrosine hydroxylase. (529 aa)
	GLDC	Glycine decarboxylase. (889 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	KCNC1	Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	UROS	Uroporphyrinogen III synthase. (265 aa)
	ENSCANP00000020568	Uncharacterized protein. (455 aa)
	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif 13. (1361 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	ENSCANP00000032715	Uncharacterized protein. (321 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
	SLC1A1	Amino acid transporter. (524 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2A	DRD2	ENSCANP00000014320	ENSCANP00000040001	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.897
ARG1	ASS1	ENSCANP00000026731	ENSCANP00000007846	Arginase.	Argininosuccinate synthase 1.	0.458
ARG1	CPS1	ENSCANP00000026731	ENSCANP00000005757	Arginase.	Carbamoyl-phosphate synthase 1.	0.719
ARG1	ENSCANP00000020568	ENSCANP00000026731	ENSCANP00000020568	Arginase.	Uncharacterized protein.	0.458
ARG1	ENSCANP00000032715	ENSCANP00000026731	ENSCANP00000032715	Arginase.	Uncharacterized protein.	0.458
ARG1	ENSCANP00000038566	ENSCANP00000026731	ENSCANP00000038566	Arginase.	Uncharacterized protein.	0.458
ASS1	ARG1	ENSCANP00000007846	ENSCANP00000026731	Argininosuccinate synthase 1.	Arginase.	0.458
ASS1	CPS1	ENSCANP00000007846	ENSCANP00000005757	Argininosuccinate synthase 1.	Carbamoyl-phosphate synthase 1.	0.907
ASS1	ENSCANP00000020568	ENSCANP00000007846	ENSCANP00000020568	Argininosuccinate synthase 1.	Uncharacterized protein.	0.402
CPS1	ARG1	ENSCANP00000005757	ENSCANP00000026731	Carbamoyl-phosphate synthase 1.	Arginase.	0.719
CPS1	ASS1	ENSCANP00000005757	ENSCANP00000007846	Carbamoyl-phosphate synthase 1.	Argininosuccinate synthase 1.	0.907
CPS1	ENSCANP00000020568	ENSCANP00000005757	ENSCANP00000020568	Carbamoyl-phosphate synthase 1.	Uncharacterized protein.	0.898
CPS1	ENSCANP00000032715	ENSCANP00000005757	ENSCANP00000032715	Carbamoyl-phosphate synthase 1.	Uncharacterized protein.	0.903
CPS1	ENSCANP00000038566	ENSCANP00000005757	ENSCANP00000038566	Carbamoyl-phosphate synthase 1.	Uncharacterized protein.	0.887
DBH	SLC18A2	ENSCANP00000037357	ENSCANP00000000681	Dopamine beta-hydroxylase.	Solute carrier family 18 member A2.	0.400
DBH	TH	ENSCANP00000037357	ENSCANP00000022579	Dopamine beta-hydroxylase.	Tyrosine hydroxylase.	0.689
DRD2	ADORA2A	ENSCANP00000040001	ENSCANP00000014320	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.897
DRD2	EDN1	ENSCANP00000040001	ENSCANP00000000830	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.849
DRD2	PPP1R1B	ENSCANP00000040001	ENSCANP00000033029	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Protein phosphatase 1 regulatory inhibitor subunit 1B.	0.440
DRD2	SLC18A2	ENSCANP00000040001	ENSCANP00000000681	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Solute carrier family 18 member A2.	0.514