(38 nodes) Mostly uncharacterized, incl. Transcription factor WhiB, and ERAP1-like C-terminal domain network (Streptomyces avermitilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nucS	Endonuclease; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (223 aa)
	KUN56277.1	PDZ/DHR/GLGF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
	KUN56279.1	NAD-dependent dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
	KUN56280.1	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
	KUN56281.1	NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
	bar	GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
	KUN57025.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
	WhmD	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
	PopR	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
	PepN3	Derived by automated computational analysis using gene prediction method: Protein Homology. (846 aa)
	KUN54406.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
	pepA	Aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (513 aa)
	KUN54432.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
	KUN54637.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
	KUN54638.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
	KUN54640.1	Pyroglutamyl peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
	KUN53618.1	DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
	KUN53262.1	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
	KUN52884.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
	KUN52887.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family. (181 aa)
	KUN52736.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	KUN52740.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
	KUN52741.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
	whiB_4	Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (87 aa)
	KUN52407.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
	KUN52408.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
	PepG	Derived by automated computational analysis using gene prediction method: Protein Homology. (859 aa)
	PepN2	Derived by automated computational analysis using gene prediction method: Protein Homology. (857 aa)
	KUN51924.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
	whiB_3	Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (112 aa)
	SlpD	Proteinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (533 aa)
	KUN51463.1	Protein often found in actinomycetes clustered with signal peptidase and/or RNaseHII; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
	KUN50826.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
	KUN50536.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
	KUN50566.1	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
	KUN50574.1	dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
	whiB	WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
	KUN46957.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)

Your Current Organism:

Streptomyces avermitilis

NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KUN46957.1	KUN50566.1	AQJ43_37515	AQJ43_32555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.414
KUN46957.1	KUN52408.1	AQJ43_37515	AQJ43_23265	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.750
KUN50536.1	KUN50574.1	AQJ43_32400	AQJ43_32595	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
KUN50536.1	KUN50826.1	AQJ43_32400	AQJ43_30610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.608
KUN50536.1	KUN53262.1	AQJ43_32400	AQJ43_19845	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.401
KUN50536.1	KUN54432.1	AQJ43_32400	AQJ43_14000	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.499
KUN50536.1	KUN54637.1	AQJ43_32400	AQJ43_15125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.684
KUN50566.1	KUN46957.1	AQJ43_32555	AQJ43_37515	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.414
KUN50566.1	KUN50574.1	AQJ43_32555	AQJ43_32595	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.682
KUN50566.1	KUN50826.1	AQJ43_32555	AQJ43_30610	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.542
KUN50566.1	KUN52407.1	AQJ43_32555	AQJ43_23260	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.429
KUN50566.1	KUN52740.1	AQJ43_32555	AQJ43_21460	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.432
KUN50566.1	KUN52884.1	AQJ43_32555	AQJ43_20485	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.532
KUN50566.1	KUN52887.1	AQJ43_32555	AQJ43_20500	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	0.522
KUN50566.1	KUN53262.1	AQJ43_32555	AQJ43_19845	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.477
KUN50566.1	KUN53618.1	AQJ43_32555	AQJ43_15965	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.566
KUN50566.1	KUN54406.1	AQJ43_32555	AQJ43_13865	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.509
KUN50566.1	KUN54432.1	AQJ43_32555	AQJ43_14000	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.706
KUN50566.1	KUN54637.1	AQJ43_32555	AQJ43_15125	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.464
KUN50566.1	KUN56280.1	AQJ43_32555	AQJ43_01330	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472

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