(103 nodes) RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation From Type 2 Promoter network (Histoplasma capsulatum NAm1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HCAG_00038	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (654 aa)
	HCAG_00078	Uncharacterized protein; Belongs to the cyclin family. (1153 aa)
	HCAG_00082	TATA-box binding protein. (268 aa)
	HCAG_00244	RPOL4c domain-containing protein. (152 aa)
	HCAG_00360	Acyl_transf_3 domain-containing protein. (189 aa)
	HCAG_00490	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (378 aa)
	HCAG_00496	Uncharacterized protein. (750 aa)
	HCAG_00556	TAF domain-containing protein. (472 aa)
	HCAG_00645	Uncharacterized protein. (296 aa)
	HCAG_00669	Uncharacterized protein. (270 aa)
	HCAG_00846	Uncharacterized protein. (413 aa)
	HCAG_00857	Uncharacterized protein. (352 aa)
	HCAG_00906	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (129 aa)
	HCAG_01022	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	HCAG_01023	Uncharacterized protein. (396 aa)
	HCAG_01031	Uncharacterized protein. (213 aa)
	HCAG_01155	Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (303 aa)
	HCAG_01248	Uncharacterized protein. (414 aa)
	HCAG_01249	TFIID_20kDa domain-containing protein. (73 aa)
	HCAG_01307	DUF4211 domain-containing protein. (223 aa)
	HCAG_01346	Nitroreductase domain-containing protein. (222 aa)
	HCAG_01366	CYCLIN domain-containing protein; Belongs to the cyclin family. (245 aa)
	HCAG_01496	Uncharacterized protein. (75 aa)
	HCAG_01528	Uncharacterized protein. (644 aa)
	HCAG_01554	Uncharacterized protein. (393 aa)
	HCAG_01901	Uncharacterized protein. (378 aa)
	HCAG_01938	Uncharacterized protein. (516 aa)
	HCAG_01948	Uncharacterized protein. (392 aa)
	HCAG_01955	Uncharacterized protein. (173 aa)
	HCAG_01970	Uncharacterized protein. (334 aa)
	HCAG_02041	Uncharacterized protein. (1007 aa)
	HCAG_02360	Uncharacterized protein. (324 aa)
	HCAG_02364	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1747 aa)
	HCAG_02380	Uncharacterized protein. (445 aa)
	HCAG_02436	Uncharacterized protein. (247 aa)
	HCAG_02711	Uncharacterized protein. (693 aa)
	HCAG_02781	Transcription initiation factor TFIId 127kD subunit. (1170 aa)
	HCAG_02810	Uncharacterized protein. (524 aa)
	HCAG_02811	Uncharacterized protein. (169 aa)
	HCAG_02833	Uncharacterized protein. (369 aa)
	HCAG_02903	CYCLIN domain-containing protein; Belongs to the cyclin family. (491 aa)
	HCAG_02928	Uncharacterized protein. (656 aa)
	HCAG_02929	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (259 aa)
	HCAG_03022	Uncharacterized protein. (410 aa)
	HCAG_03024	Uncharacterized protein. (1227 aa)
	HCAG_03109	Protein kinase domain-containing protein. (238 aa)
	HCAG_03119	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (180 aa)
	HCAG_03433	TFIIS N-terminal domain-containing protein. (423 aa)
	HCAG_03460	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1424 aa)
	HCAG_03505	Helicase ATP-binding domain-containing protein. (501 aa)
	HCAG_03746	DUF3591 domain-containing protein. (1092 aa)
	HCAG_03784	Uncharacterized protein. (123 aa)
	HCAG_03828	Uncharacterized protein. (621 aa)
	HCAG_03901	CID domain-containing protein. (246 aa)
	HCAG_04046	Serine/threonine-protein kinase crk1; Belongs to the protein kinase superfamily. (408 aa)
	HCAG_04427	Uncharacterized protein. (510 aa)
	HCAG_04441	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1743 aa)
	HCAG_04472	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (363 aa)
	HCAG_04624	DNA-directed RNA polymerases I and III 40 kDa polypeptide. (380 aa)
	HCAG_04635	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (571 aa)
	HCAG_04703	Uncharacterized protein. (632 aa)
	HCAG_04738	Uncharacterized protein. (201 aa)
	HCAG_04750	Uncharacterized protein. (715 aa)
	HCAG_04864	DNA-directed RNA polymerases I. (177 aa)
	HCAG_05207	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (298 aa)
	HCAG_06417	DNA-directed RNA polymerase II 13.3 kDa polypeptide. (168 aa)
	HCAG_06637	Uncharacterized protein. (818 aa)
	HCAG_06714	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1573 aa)
	HCAG_06715	DNA repair helicase RAD3. (683 aa)
	HCAG_06723	Uncharacterized protein. (90 aa)
	HCAG_06734	DNA-directed RNA polymerases II 24 kDa polypeptide. (236 aa)
	HCAG_06934	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (506 aa)
	HCAG_06971	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1186 aa)
	RPC82	DNA-directed RNA polymerase III subunit rpc3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity). (649 aa)
	HCAG_05716	BTB domain-containing protein. (867 aa)
	HCAG_05909	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1214 aa)
	HCAG_05932	RPOLD domain-containing protein. (576 aa)
	HCAG_06230	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1080 aa)
	HCAG_07073	RING-type domain-containing protein. (379 aa)
	HCAG_07118	Uncharacterized protein. (434 aa)
	HCAG_07353	HTH TFE/IIEalpha-type domain-containing protein. (441 aa)
	HCAG_07360	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (104 aa)
	HCAG_07588	Uncharacterized protein. (248 aa)
	HCAG_07638	Uncharacterized protein. (720 aa)
	HCAG_07759	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (455 aa)
	HCAG_07839	CDC73_C domain-containing protein. (519 aa)
	HCAG_07976	Acyl_transf_3 domain-containing protein. (459 aa)
	HCAG_08011	Uncharacterized protein. (323 aa)
	HCAG_08069	Uncharacterized protein. (544 aa)
	HCAG_08091	RTR1-type domain-containing protein. (449 aa)
	HCAG_08226	RNA_pol_L_2 domain-containing protein. (137 aa)
	HCAG_08238	FCP1 homology domain-containing protein. (700 aa)
	HCAG_08245	SANT domain-containing protein. (542 aa)
	HCAG_08300	BTP domain-containing protein. (214 aa)
	HCAG_08301	TAFII55_N domain-containing protein. (559 aa)
	HCAG_08376	Spt4 domain-containing protein. (204 aa)
	HCAG_08797	RPOL9 domain-containing protein. (140 aa)
	HCAG_08803	Transcription initiation factor IIB. (352 aa)
	HCAG_08810	Uncharacterized protein. (684 aa)
	HCAG_08845	Plus3 domain-containing protein. (637 aa)
	HCAG_08886	Uncharacterized protein. (371 aa)
	HCAG_08895	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1439 aa)
	HCAG_08910	DNA repair protein Rex1. (72 aa)

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00038	HCAG_00078	A6QRN2	A6QRS2	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein; Belongs to the cyclin family.	0.809
HCAG_00038	HCAG_00082	A6QRN2	A6QRS6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	TATA-box binding protein.	0.450
HCAG_00038	HCAG_00244	A6QRN2	A6QS88	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOL4c domain-containing protein.	0.931
HCAG_00038	HCAG_00490	A6QRN2	A6QSY4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.766
HCAG_00038	HCAG_00645	A6QRN2	A6QTD9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.598
HCAG_00038	HCAG_00669	A6QRN2	A6QTG3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.587
HCAG_00038	HCAG_00906	A6QRN2	A6QU50	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.742
HCAG_00038	HCAG_01346	A6QRN2	A6QVD9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Nitroreductase domain-containing protein.	0.587
HCAG_00038	HCAG_01366	A6QRN2	A6QVF9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.660
HCAG_00038	HCAG_01496	A6QRN2	A6QVT9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.748
HCAG_00038	HCAG_01554	A6QRN2	A6QVZ7	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.587
HCAG_00038	HCAG_01901	A6QRN2	A6QWZ4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.947
HCAG_00038	HCAG_02041	A6QRN2	A6QXD4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.701
HCAG_00038	HCAG_02364	A6QRN2	A6QYA7	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.988
HCAG_00038	HCAG_02810	A6QRN2	A6QZK3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.886
HCAG_00038	HCAG_02811	A6QRN2	A6QZK4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.957
HCAG_00038	HCAG_02833	A6QRN2	A6QZM6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.932
HCAG_00038	HCAG_02903	A6QRN2	A6QZU6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.717
HCAG_00038	HCAG_03022	A6QRN2	A6R065	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.587
HCAG_00038	HCAG_03109	A6QRN2	A6R0F2	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Protein kinase domain-containing protein.	0.769