(44 nodes) Sm-like protein family complex, and Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) network (Cryptosporidium parvum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	cgd7_3970	Small nuclear ribonucleoprotein, putative. (62 aa)
	cgd6_2150	U1 snrnp, putative. (267 aa)
	cgd3_2310	RRM domain-containing protein. (86 aa)
	cgd3_3690	U5 snRNP 100 kD protein, putative; Belongs to the DEAD box helicase family. (529 aa)
	cgd1_2690	Sm domain-containing protein. (67 aa)
	cgd1_2910	Sm domain-containing protein. (139 aa)
	cgd5_1130	WD-40 repeat protein family / small nuclear ribonucleoprotein Prp4p-related. (439 aa)
	cgd5_2970	Uncharacterized protein. (622 aa)
	cgd5_2980	SEC63 domain-containing protein. (367 aa)
	cgd4_1660	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	cgd4_2710	Uncharacterized protein. (77 aa)
	cgd4_3190	Small nuclear ribonucleoprotein Sm D2. (106 aa)
	cgd4_890	Uncharacterized protein. (85 aa)
	cgd5_4060	Matrin-type domain-containing protein. (198 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (160 aa)
	Ms15p	Ms15p KH + 2 Znknuckle (C2HC). (471 aa)
	cgd4_150	Pre-mRNA splicing protein Prp31p--like. (463 aa)
	cgd4_3140	WD repeat protein. (343 aa)
	cgd4_1570	Uncharacterized protein. (407 aa)
	cgd5_2960	U5snrp Brr2 SFII RNA helicase (sec63 and the second part of the RNA). (1204 aa)
	cgd5_2220	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (137 aa)
	cgd5_1740	Conserved protein, possible U4/U6 associated RNA splicing factor. (452 aa)
	cgd5_920	Pre-mRNA splicing factor Pro1/Prp6. HAT repeat protein. (923 aa)
	cgd1_2250	Small nuclear ribonucleoprotein Sm D3. (143 aa)
	cgd2_3510	Cus1p U2 snRNP protein. (602 aa)
	cgd3_3880	Snu114p GTpase, U5 snRNP-specific protein, 116 kDa. (1035 aa)
	cgd3_2890	Prp8. JAB/PAD domain. (2379 aa)
	cgd3_1880	Protein with 2x rrm domains. (1142 aa)
	cgd3_1060	U1 like C2H2 zinc finger. (198 aa)
	cgd8_4240	Possible spliceosome factor. (1317 aa)
	cgd8_3690	Mitosis protein DIM1. (142 aa)
	cgd6_4750	Splicing factor 3B subunit1-like HEAT repeat containing protein. (1031 aa)
	cgd6_4670	Prp9p-like splicing factor 3a subunit 3 snRNP. (493 aa)
	cgd6_4490	RRM domain containing protein. (216 aa)
	cgd6_2830	Splicing factor 3a 66kD N-terminus C2H2 domain. (216 aa)
	cgd6_990	RRM domain containing protein. (281 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (99 aa)
	cgd7_5160	U1 small nuclear ribonucleoprotein A, rrm domain. (122 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (121 aa)
	cgd7_3520	Sm domain-containing protein. (73 aa)
	cgd7_2160	Pre-mRNA splicing factor SF3a. 2xSWAP domain protein. (462 aa)
	cgd7_2040	Small nuclear ribonucleo protein. (93 aa)
	cgd7_1070	SnRNP core protein. (107 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)

Your Current Organism:

Cryptosporidium parvum

NCBI taxonomy Id: 353152
Other names: C. parvum Iowa II, Cryptosporidium parvum Iowa II, Cryptosporidium parvum strain Iowa type II

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM1	LSM3	Q5CQ90	Q5CYX1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999
LSM1	LSM5	Q5CQ90	Q5CXX3	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	0.999
LSM1	LSM8	Q5CQ90	Q5CXQ2	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.995
LSM1	cgd1_2250	Q5CQ90	Q5CSL0	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleoprotein Sm D3.	0.777
LSM1	cgd1_2690	Q5CQ90	A3FQF0	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Sm domain-containing protein.	0.765
LSM1	cgd1_2910	Q5CQ90	A3FQF4	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Sm domain-containing protein.	0.764
LSM1	cgd3_1880	Q5CQ90	Q5CUQ5	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Protein with 2x rrm domains.	0.568
LSM1	cgd3_3690	Q5CQ90	A3FQ46	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	U5 snRNP 100 kD protein, putative; Belongs to the DEAD box helicase family.	0.624
LSM1	cgd4_1660	Q5CQ90	A3FQK4	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.840
LSM1	cgd4_2710	Q5CQ90	A3FQL4	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.999
LSM1	cgd4_3190	Q5CQ90	A3FQL7	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleoprotein Sm D2.	0.831
LSM1	cgd5_2220	Q5CQ90	Q5CRM6	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.796
LSM1	cgd6_990	Q5CQ90	Q5CXI3	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	RRM domain containing protein.	0.411
LSM1	cgd7_1070	Q5CQ90	Q5CYT7	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	SnRNP core protein.	0.999
LSM1	cgd7_2040	Q5CQ90	Q5CYJ9	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleo protein.	0.999
LSM1	cgd7_3520	Q5CQ90	Q5CY65	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Sm domain-containing protein.	0.999
LSM1	cgd7_3970	Q5CQ90	A3FPQ3	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Small nuclear ribonucleoprotein, putative.	0.657
LSM3	LSM1	Q5CYX1	Q5CQ90	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	0.999
LSM3	LSM5	Q5CYX1	Q5CXX3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.	0.999
LSM3	LSM8	Q5CYX1	Q5CXQ2	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.999