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PF3D7_1472200 PF3D7_1472200 PF3D7_1326100 PF3D7_1326100 PF3D7_1352200 PF3D7_1352200 PF3D7_0416400 PF3D7_0416400 PF3D7_0807000 PF3D7_0807000 PF3D7_0605300 PF3D7_0605300 PF3D7_0628600 PF3D7_0628600 SET1 SET1 PF3D7_0309200 PF3D7_0309200 PF3D7_0319300 PF3D7_0319300 PF3D7_1361000 PF3D7_1361000 PF3D7_0209700 PF3D7_0209700 PF3D7_0925700 PF3D7_0925700 PF3D7_0403900 PF3D7_0403900 PF3D7_1356800 PF3D7_1356800 PF3D7_1323300 PF3D7_1323300 SETVS SETVS PF3D7_1303800 PF3D7_1303800 PF3D7_1303400 PF3D7_1303400 PF3D7_1149000 PF3D7_1149000 PF3D7_1145200 PF3D7_1145200 PF3D7_1118600 PF3D7_1118600 PF3D7_1106000 PF3D7_1106000 PF3D7_1103600 PF3D7_1103600 PF3D7_1027000 PF3D7_1027000 PF3D7_1008000 PF3D7_1008000 PF3D7_1466200 PF3D7_1466200 Sir2B Sir2B PF3D7_1422800 PF3D7_1422800 PF3D7_1407100 PF3D7_1407100 PF3D7_0520700 PF3D7_0520700 PF3D7_0505200 PF3D7_0505200 PF3D7_1243800 PF3D7_1243800 PF3D7_0809700 PF3D7_0809700 PF3D7_0812600 PF3D7_0812600 PF3D7_0826300 PF3D7_0826300 PF3D7_1362200 PF3D7_1362200
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF3D7_1472200Histone deacetylase, putative. (2251 aa)
PF3D7_1326100WD repeat-containing protein, putative. (336 aa)
PF3D7_1352200U3 small nucleolar RNA-associated protein 15, putative. (464 aa)
PF3D7_0416400Histone acetyltransferase, putative. (1259 aa)
PF3D7_0807000YEATS domain-containing protein, putative. (222 aa)
PF3D7_0605300Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (353 aa)
PF3D7_0628600DNA methyltransferase 1-associated protein 1, putative. (385 aa)
SET1Putative histone-lysine N-methyltransferase 1; Probable histone methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. (6753 aa)
PF3D7_0309200Serine/threonine protein kinase, putative. (1650 aa)
PF3D7_0319300Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
PF3D7_1361000Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. (724 aa)
PF3D7_0209700RING zinc finger protein, putative. (568 aa)
PF3D7_0925700Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (449 aa)
PF3D7_0403900SET domain protein, putative. (1186 aa)
PF3D7_1356800Serine/threonine protein kinase, putative. (4044 aa)
PF3D7_1323300N-acetyltransferase, GNAT family, putative. (352 aa)
SETVSVariant-silencing SET domain-containing protein; Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to t [...] (2548 aa)
PF3D7_1303800Uncharacterized protein. (9271 aa)
PF3D7_1303400LisH domain-containing protein, putative. (1022 aa)
PF3D7_1149000Antigen 332, DBL-like protein. (6093 aa)
PF3D7_1145200Serine/threonine protein kinase, putative. (2015 aa)
PF3D7_1118600Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (608 aa)
PF3D7_1106000RuvB-like helicase; Belongs to the RuvB family. (475 aa)
PF3D7_1103600Actin-like protein, putative; Belongs to the actin family. (499 aa)
PF3D7_1027000Uncharacterized protein. (1811 aa)
PF3D7_1008000Histone deacetylase 2. (2379 aa)
PF3D7_1466200Early gametocyte enriched phosphoprotein EGXP. (3078 aa)
Sir2BNAD-dependent protein deacetylase Sir2B; Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2A to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. (1304 aa)
PF3D7_1422800Actin-related protein, putative; Belongs to the actin family. (522 aa)
PF3D7_1407100rRNA 2'-O-methyltransferase fibrillarin, putative. (318 aa)
PF3D7_0520700CDC73 domain-containing protein, putative. (974 aa)
PF3D7_0505200Actin-like protein, putative; Belongs to the actin family. (565 aa)
PF3D7_1243800WD repeat-containing protein 82, putative. (370 aa)
PF3D7_0809700RuvB-like helicase; Belongs to the RuvB family. (520 aa)
PF3D7_0812600Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
PF3D7_0826300SPRY domain, putative. (445 aa)
PF3D7_1362200RuvB-like helicase; Belongs to the RuvB family. (483 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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