STRINGSTRING
ABI4 ABI4 PTAC12 PTAC12 SIB2 SIB2 CP31A CP31A THY-1 THY-1 THY-2 THY-2 CP29A CP29A WRKY33 WRKY33 SIB1 SIB1 TGD2 TGD2 MFP1 MFP1 CP29B CP29B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABI4Ethylene-responsive transcription factor ABI4; Transcription regulator that probably binds to the GCC-box pathogenesis-related promoter element. Binds also to the S-box (5'- CACTTCCA-3') photosynthesis-associated nuclear genes-related (PhANGs- related) promoter element, and thus acts as a transcription inhibitor. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. May have a function in the deetiolation process. Confers sensitivity to abscisic acid (ABA), and regulates the ABA signaling pathway during seed germinatio [...] (328 aa)
PTAC12Protein PLASTID TRANSCRIPTIONALLY ACTIVE 12, chloroplastic; Involved in plastid gene expression. Required in the nucleus for the initiation of photomorphogenesis mediated by phytochromes (PHYs) (e.g. PHYA and PHYB) by mediating PHYs localization to photobodies, especially in response to red and far-red light, and implicating phytochrome nuclear bodies as sites of proteolysis for PHYs and PIFs proteins (e.g. PIF1 and PIF3). Acts downstream of PHYs and upstream of DET1. (527 aa)
SIB2Sigma factor binding protein 2, chloroplastic; Functions as activator of WRKY33 in plant defense against necrotrophic pathogens by stimulating the DNA-binding activity of WRKY33. (141 aa)
CP31A31 kDa ribonucleoprotein, chloroplastic; Required for specific RNA editing events in chloroplasts and stabilizes specific chloroplast mRNAs. Associates with the 3'-terminus ndhF mRNAs and protects them against 3'-exonucleolytic degradation. Required for normal chloroplast development under cold stress conditions by stabilizing transcripts of numerous mRNAs under these conditions. May modulate telomere replication through RNA binding domains. (329 aa)
THY-1Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP. (519 aa)
THY-2Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family. (565 aa)
CP29A29 kDa ribonucleoprotein, chloroplastic; Stabilizes specific chloroplast mRNAs. Required for normal chloroplast development under cold stress conditions by stabilizing transcripts of numerous mRNAs under these conditions. (342 aa)
WRKY33Probable WRKY transcription factor 33; Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Involved in defense responses. Required for resistance to the necrotrophic fungal pathogen B.cinerea. Regulates the antagonistic relationship between defense pathways mediating responses to the bacterial pathogen P. syringae and the necrotrophic pathogen B.cinerea. Required for the phytoalexin camalexin synthesis following infection with B.cinerea. Acts as positive regulator of the camalexin biosynthetic ge [...] (519 aa)
SIB1Sigma factor binding protein 1, chloroplastic; Contributes to plant defense. May regulate chloroplast metabolism upon infection with pathogens such as Pseudomonas syringae. Functions as activator of WRKY33 in plant defense against necrotrophic pathogens by stimulating the DNA-binding activity of WRKY33. (151 aa)
TGD2Protein TRIGALACTOSYLDIACYLGLYCEROL 2, chloroplastic; Component of a phosphatidic acid/lipid transport complex in the chloroplast envelope. Specifically binds phosphatidic acid (PA). Involved in lipid transfer from the endoplasmic reticulum (ER) to plastids, and necessary for thylakoids formation. (381 aa)
MFP1MAR-binding filament-like protein 1; Binds DNA. Interacts with chromatin via matrix attachment regions (MARs). Likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (By similarity). (726 aa)
CP29BRNA-binding protein CP29B, chloroplastic; Could be involved in splicing and/or processing of chloroplast RNA's. (289 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (28%) [HD]