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| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | tdk | Probable thymidine kinase protein. (208 aa) |
| | folE | Probable gtp cyclohydrolaseIprotein. (200 aa) |
| | XALC_3085 | Putative porphyrin biosynthesis protein. (421 aa) |
| | XALC_3083 | Putative uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (266 aa) |
| | hemB | Probable delta-aminolevulinic acid dehydratase (porphobilinogen synthase) protein; Belongs to the ALAD family. (330 aa) |
| | atpB | Probable h+-transporting two-sector atpase, a subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (264 aa) |
| | atpE | Probable atp synthase, c subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (99 aa) |
| | atpF | Probable atp synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | Probable h+-transporting two-sector atpase, delta (oscp) subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (175 aa) |
| | atpA | Probable atp synthase, alpha subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (515 aa) |
| | atpG | Probable atp synthase, gamma subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpD | Probable atp synthase, beta subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa) |
| | atpC | Probable atp synthase epsilon subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (455 aa) |
| | Rho | Putative transcription termination factor rho protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (426 aa) |
| | rpoH | Probable rna polymerase sigma-32 factor protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (292 aa) |
| | PriA | Putative primosome assembly protein, superfamily II helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (729 aa) |
| | RibA | Putative gtp cyclohydrolase II, riboflavin biosynthesis protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (376 aa) |
| | rpoD | Probable rna polymerase sigma-70 factor, rpod protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (620 aa) |
| | ribD | Probable riboflavin biosynthesis ribd oxidoreductase protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa) |
| | RibC | Putative riboflavin synthase, alpha subunit protein. (199 aa) |
| | RibB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (385 aa) |
| | RibH | Putative 6,7-dimethyl-8-ribityllumazine synthase, riboflavin synthase beta subunit protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (155 aa) |
| | NusB | Putative transcription termination factor nusb protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (155 aa) |
| | thiL | Putative thiamine monophosphate kinase protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa) |
| | thyA | Probable thymidylate synthase protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | XALC_2767 | Probable dihydrofolate reductase protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (169 aa) |
| | apaG | Probable protein apag. (127 aa) |
| | pdxA | Probable 4-hydroxythreonine-4-phosphate dehydrogenase protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (324 aa) |
| | XALC_2759 | Putative adenosyl transferase protein; Belongs to the Cob(I)alamin adenosyltransferase family. (184 aa) |
| | XALC_2750 | Putative gluconolactonase protein. (298 aa) |
| | queF | Putative nadph-dependent 7-cyano-7-deazaguanine reductase protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (272 aa) |
| | dinB | Probable dna polymerase iv protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (353 aa) |
| | bioD | Probable dethiobiotin synthase protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (231 aa) |
| | ptpS | Probable 6-pyruvoyltetrahydropterin synthase protein. (120 aa) |
| | XALC_2703 | Probable protoporphyrinogen oxidase protein. (441 aa) |
| | rmlB | Probable dtdp-glucose 4,6-dehydratase protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa) |
| | rmlA | Probable glucose-1-phosphate thymidylyltransferase protein; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (295 aa) |
| | rmlC | Probable dtdp-4-dehydrorhamnose 3,5-epimerase protein; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | rmlD | Probable dtdp-4-dehydrorhamnose reductase protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (304 aa) |
| | xanB | Probable mannose-6-phosphate isomerase protein; Belongs to the mannose-6-phosphate isomerase type 2 family. (467 aa) |
| | xanA | Probable phosphoglucomutase / phosphomannomutase protein. (448 aa) |
| | holC | Probable dna polymerase III subunit chi protein. (140 aa) |
| | purL | Probable phosphoribosylformylglycinamidine synthase protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1323 aa) |
| | XALC_2628 | Hypothetical protein. (168 aa) |
| | XALC_2627 | Conserved hypothetical protein. (87 aa) |
| | hemC | Probable hydroxymethylbilane synthase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (302 aa) |
| | rpoE1 | Probable rna polymerase sigma-e factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (206 aa) |
| | XALC_2533 | Putative phosphoribosyltransferase protein. (184 aa) |
| | XALC_2532 | Putative purine-nucleoside phosphorylase protein; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (248 aa) |
| | rpoE2 | Probable rna polymerase sigma-e factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | XALC_2484 | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (257 aa) |
| | holA | Probable dna polymerase III delta subunit protein. (344 aa) |
| | nadD | Putative nicotinamide-nucleotide adenylyltransferase protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (229 aa) |
| | XALC_2469 | Putative carbamoyl-phosphate synthase, cpsase protein. (423 aa) |
| | NrdG | Putative organic radical activating enzyme protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (225 aa) |
| | exsB | Putative transcriptional regulator, exsb family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (221 aa) |
| | XALC_2396 | Hypothetical protein. (156 aa) |
| | XALC_2395 | Conserved hypothetical protein. (87 aa) |
| | XALC_2390 | Putative bacteriophage related protein. (754 aa) |
| | XALC_2345 | Putative von willebrand factor, type a protein. (343 aa) |
| | ThiG | Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa) |
| | ThiS | Putative sulfur carrier protein involved in thiamine biosynthesis. (66 aa) |
| | XALC_2212 | Putative adenosylmethionine--8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (463 aa) |
| | hemE | Putative uroporphyrinogen decarboxylase protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | pdxH | Putative pyridoxamine 5'-phosphate oxidase protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (199 aa) |
| | proC | Probable pyrroline-5-carboxylate reductase (p5cr) protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa) |
| | XALC_2157 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | PyrB | Putative aspartate carbamoyltransferase, catalytic subunit protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa) |
| | rpoN2 | Probable rna polymerase sigma-54 factor protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (485 aa) |
| | murA | Probable udp-n-acetylglucosamine 1-carboxyvinyltransferase protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (424 aa) |
| | PurU | Putative phosphoribosylglycinamide formyltransferase protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | PurM | Putative phosphoribosylaminoimidazole synthetase protein. (340 aa) |
| | FdhD | Putative formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (279 aa) |
| | XALC_2102 | Hypothetical protein. (90 aa) |
| | corC | Probable magnesium and cobalt efflux protein. (293 aa) |
| | XALC_2042 | Hypothetical protein. (150 aa) |
| | accA | Probable acetyl-coenzyme a carboxylase carboxyl transferase subunit alpha protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | dnaE | Probable dna polymerase III, alpha chain protein. (1198 aa) |
| | pyrH | Probable uridylate kinase protein; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | XALC_1971 | Putative aminotransferase class-III family protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (168 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (371 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (392 aa) |
| | pyrC | Putative dihydroorotase domain protein. (444 aa) |
| | proB | Probable glutamate 5-kinase (gamma-glutamyl kinase) (gk) protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (388 aa) |
| | XALC_1860 | Conserved hypothetical protein. (696 aa) |
| | XALC_1859 | Conserved hypothetical protein. (120 aa) |
| | kdsB | Putative 3-deoxy-manno-octulosonate cytidylyltransferase protein; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (261 aa) |
| | XALC_1801 | Conserved hypothetical protein. (128 aa) |
| | ppnK | Probable inorganic polyphosphate/atp-nad kinase (poly(p)/atp nad kinase) protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa) |
| | kmo | Putative kynurenine 3-monooxygenase oxidoreductase protein; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (454 aa) |
| | kynU | Putative kynureninase protein; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (423 aa) |
| | nbaC | Putative 3-hydroxyanthranilate 3,4-dioxygenase protein; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa) |
| | albXXI | Probable phosphopantheteinyl transferase, albicidin synthetase protein; Belongs to the P-Pant transferase superfamily. (278 aa) |
| | serC | Probable phosphoserine aminotransferase (psat) protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | serS | Probable seryl-trna synthetase (serine--trna ligase) (serrs) protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (437 aa) |
| | XALC_1667 | Hypothetical protein. (295 aa) |
| | purB | Probable adenylosuccinate lyase protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | ugd | Probable udp-glucose 6-dehydrogenase protein. (448 aa) |
| | XALC_1630 | Conserved hypothetical protein. (128 aa) |
| | phhB | Putative pterin-4-alpha-carbinolamine dehydratase (phs) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin carbinolamine dehydratase) (pcd) protein. (113 aa) |
| | cmk | Probable cytidylate kinase protein. (223 aa) |
| | ndk | Probable nucleoside diphosphate kinase (ndk) (ndp kinase)(nucleoside-2-p kinase) protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | mobA | Probable molybdopterin-guanine dinucleotide biosynthesis protein a; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.; Belongs to the MobA family. (201 aa) |
| | moeA | Probable molybdopterin biosynthesis protein moea; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (405 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | guaB | Probable inosine-5-monophosphate dehydrogenase protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | guaA | Probable gmp synthase (glutamine amidotransferase) protein; Catalyzes the synthesis of GMP from XMP. (521 aa) |
| | repC | Putative replication protein c. (210 aa) |
| | albXVIII | Putative 4-amino-4-deoxychorismate lyase; albicidin synthetase protein. (123 aa) |
| | xsaS | Probable xanthomonas secretion apparatus protein. (449 aa) |
| | rpoE3 | Probable rna polymerase sigma-e factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | rpoN1 | Probable rna polymerase sigma-54 factor protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (466 aa) |
| | fliI | Probable flagellum-specific atp synthase protein. (458 aa) |
| | fliA | Probable rna polymerase sigma factor for flagellar operon (sigma-f factor) protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (249 aa) |
| | greA | Probable transcription elongation factor grea (transcript cleavage factor grea) protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa) |
| | carB | Probable carbamoyl-phosphate synthetase large chain protein; Belongs to the CarB family. (1080 aa) |
| | carA | Probable carbamoyl-phosphate synthase (glutamine-hydrolyzing) protein; Belongs to the CarA family. (374 aa) |
| | XALC_1313 | Conserved hypothetical protein; Belongs to the BolA/IbaG family. (94 aa) |
| | purK | Probable phosphoribosylaminoimidazole carboxylase atpase subunit (air carboxylase) protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (382 aa) |
| | purE | Probable phosphoribosylaminoimidazole carboxylase catalytic subunit protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | nadC | Probable nicotinate-nucleotide pyrophosphorylase protein; Belongs to the NadC/ModD family. (292 aa) |
| | pyrD | Putative dihydroorotate dehydrogenase (dihydroorotate oxidase) protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (351 aa) |
| | folK-2 | Probable 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, hppk; protein. (137 aa) |
| | folE2 | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (311 aa) |
| | XALC_1188 | Hypothetical protein. (307 aa) |
| | thiD | Probable phosphomethylpyrimidine kinase (hmp-p kinase) protein. (275 aa) |
| | XALC_1169 | Hypothetical competence-damaged protein; Belongs to the CinA family. (164 aa) |
| | folP | Probable dihydropteroate synthase, dhps protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (300 aa) |
| | pyrG | Probable ctp synthase (utp--ammonia ligase) protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (554 aa) |
| | dnaB | Putative replicative dna helicase protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (472 aa) |
| | dxs | Probable 1-deoxy-d-xylulose-5-phosphate synthase (dxp-synthase) protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa) |
| | murD | Putative udp-n-acetylmuramoylalanine--d-glutamate ligase protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (470 aa) |
| | XALC_1026 | Putative acetyltransferase (gnat) family protein. (178 aa) |
| | nusA | Probable transcription elongation protein nusa; Participates in both transcription termination and antitermination. (503 aa) |
| | accD-2 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (295 aa) |
| | trpA | Probable tryptophan synthase alpha chain protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | trpB | Probable tryptophan synthase beta chain protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | trpF | Probable n-(5'-phosphoribosyl)anthranilate isomerase (ec) (prai) protein; Belongs to the TrpF family. (220 aa) |
| | greB | Probable transcription elongation factor greb (transcript cleavage factor greb) protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (168 aa) |
| | dcd | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | XALC_0950 | Putative 2-nitropropane dioxygenase oxidoreductase protein. (355 aa) |
| | XALC_0934 | Probable transferase protein. (448 aa) |
| | ribF | Probable riboflavin biosynthesis protein; Belongs to the ribF family. (329 aa) |
| | purT | Probable phosphoribosylglycinamide formyltransferase 2 protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (395 aa) |
| | XALC_0846 | Putative transaminase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa) |
| | folK | Probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein. (167 aa) |
| | XALC_0821 | Probable nicotinamide phosphoribosyltransferase protein; Belongs to the NAPRTase family. (474 aa) |
| | lipA | Probable lipoyl synthase (lipoyl-acyl-carrier-protein synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa) |
| | spoT | Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (723 aa) |
| | rpoZ | Probable dna-directed rna polymerase omega subunit protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (99 aa) |
| | gmk | Probable guanylate kinase (gmp kinase) protein; Essential for recycling GMP and indirectly, cGMP. (208 aa) |
| | XALC_0793 | Putative coproporphyrinogen III oxidase protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa) |
| | XALC_0784 | Hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (197 aa) |
| | thiE | Probable thiamine-phosphate pyrophosphorylase protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | hemL | Probable glutamate-1-semialdehyde 2, 1-aminomutase protein. (430 aa) |
| | adk | Probable adenylate kinase protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (187 aa) |
| | thiC | Probable thiamine biosynthesis protein thic; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (627 aa) |
| | XALC_0722 | Conserved hypothetical protein. (408 aa) |
| | nadE | Putative nad(+) synthase (glutamine-hydrolyzing) protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (549 aa) |
| | coaE | Probable dephospho-coa kinase (dephosphocoenzyme a kinase) protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | purA | Probable adenylosuccinate synthetase (imp--aspartate ligase) protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | holB | Probable dna polymerase III, delta prime subunit protein. (320 aa) |
| | tmk | Probable thymidylate kinase (dtmp kinase) protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa) |
| | dnaX | Probable dna polymerase III tau and gamma subunits protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (611 aa) |
| | moaE | Probable molybdopterin-converting factor chain 2 protein. (141 aa) |
| | moaD | Probable molybdopterin-converting factor chain 1 protein. (81 aa) |
| | moaC | Probable molybdenum cofactor biosynthesis protein c. (172 aa) |
| | moaA | Probable molybdenum cofactor biosynthesis protein a; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (344 aa) |
| | dnaQ | Probable dna polymerase III, epsilon subunit protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (244 aa) |
| | purF | Probable amidophosphoribosyltransferase protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (488 aa) |
| | folC | Probable folc bifunctional protein [includes folylpolyglutamate synthase and dihydrofolate synthase]; Belongs to the folylpolyglutamate synthase family. (423 aa) |
| | kbl | Probable 2-amino-3-ketobutyrate coenzyme a ligase protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (400 aa) |
| | rpoA | Probable dna-directed rna polymerase alpha chain (rna polymerase alpha subunit) protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa) |
| | rpoC | Probable dna-directed rna polymerase, subunit beta-prime protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1405 aa) |
| | rpoB | Probable dna-directed rna polymerase, beta subunit protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1383 aa) |
| | nusG | Probable transcription antitermination protein nusg; Participates in transcription elongation, termination and antitermination. (185 aa) |
| | prs | Probable ribose-phosphate diphosphokinase protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | hemA | Probable glutamyl-trna reductase (glutr) protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (427 aa) |
| | moaB | Probable molybdenum cofactor biosynthesis protein b; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (172 aa) |
| | XALC_0471 | Putative rna polymerase ecf-type sigma factor transcription regulator protein; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | folB | Probable dihydroneopterin aldolase protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | dnaG | Probable dna primase protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (578 aa) |
| | cyoE | Putative cytochrome c oxidase assembly factor protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (299 aa) |
| | XALC_0408 | Hypothetical protein. (387 aa) |
| | pyrE | Probable orotate phosphoribosyltransferase protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa) |
| | dut | Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (428 aa) |
| | bioB | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (347 aa) |
| | bioF | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (407 aa) |
| | bioH | Probable carboxylesterase bioh (biotin synthesis protein bioh); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (253 aa) |
| | bioC | Probable biotin synthesis protein bioc; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (298 aa) |
| | XALC_0335 | Hypothetical protein. (117 aa) |
| | accC-2 | Probable acetyl-coa carboxylase, biotin carboxylase subunit protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa) |
| | purH | Probable protein purh, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/imp cyclohydrolase. (528 aa) |
| | purD | Probable phosphoribosylamine--glycine ligase (gars) (glycinamideribonucleotide synthetase) (phosphoribosylglycinamide synthetase) protein; Belongs to the GARS family. (429 aa) |
| | trpC | Probable indole-3-glycerol phosphate synthase protein; Belongs to the TrpC family. (264 aa) |
| | trpD | Probable anthranilate phosphoribosyltransferase protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | trpE | Probable anthranilate synthase componentIprotein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate an [...] (491 aa) |
| | purC | Probable phosphoribosylaminoimidazole-succinocarboxamide synthase protein; Belongs to the SAICAR synthetase family. (308 aa) |
| | coaX | Putative transcriptional regulator, bvg accessory factor family transcription regulator protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (246 aa) |
| | XALC_0198 | Hypothetical protein. (822 aa) |
| | nrdB | Probable ribonucleotide-diphosphate reductase beta subunit protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (346 aa) |
| | hemF | Probable coproporphyrinogen 3 oxidase, aerobic protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (299 aa) |
| | polA | Probable dna polymeraseIprotein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (922 aa) |
| | gla | Putative nucleoside-diphosphate-sugar epimerases protein. (321 aa) |
| | acsA | Probable acetyl-coenzyme a synthetase protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa) |
| | queH | Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (220 aa) |
| | hemH | Probable ferrochelatase (protoheme ferro-lyase) (hemesynthetase) protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (319 aa) |
| | pyrF | Probable orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (244 aa) |
| | pdxJ | Probable pyridoxal phosphate biosynthetic protein pdxj (pnp synthase); Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (255 aa) |
| | dnaN | Probable dna polymerase III subunit beta protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required f [...] (366 aa) |
