(29 nodes) Thiolase-like network (Cupriavidus necator)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	h16_A0170	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	h16_A0462	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	paaJ	3-Ketoacyl-CoA-thiolase P-44/SCP2; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	h16_A0867	Acetyl-CoA acetyltransferase. (391 aa)
	h16_A0868	Acetyl-CoA acetyltransferase. (399 aa)
	h16_A0872	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	h16_A1290	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	h16_A1297	Acetyl-CoA acetyltransferase. (388 aa)
	phaA	Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB. (393 aa)
	bktB	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	h16_A1528	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	h16_A1713	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	h16_A1720	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	h16_A1887	Acetyl-CoA acetyltransferase; Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	h16_A2148	Acetyl-CoA acetyltransferase. (386 aa)
	h16_A2155	Acetyl-CoA acetyltransferase truncated. (257 aa)
	fabF	3-Oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
	fabH	3-Oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
	pcaF	Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	h16_B0381	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	h16_B0406	Acetyl-CoA acetyltransferase. (388 aa)
	h16_B0591	Acetyl-CoA synthetase. (390 aa)
	h16_B0662	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
	h16_B0668	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	h16_B0759	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
	h16_B1369	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
	fabB	3-Oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (400 aa)
	h16_B1668	Conserved hypothetical protein. (270 aa)
	h16_B1903	Probable lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (381 aa)

Your Current Organism:

Cupriavidus necator

NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bktB	h16_A0170	H16_A1445	H16_A0170	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.688
bktB	h16_A0462	H16_A1445	H16_A0462	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.710
bktB	h16_A0867	H16_A1445	H16_A0867	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase.	0.600
bktB	h16_A0868	H16_A1445	H16_A0868	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase.	0.600
bktB	h16_A0872	H16_A1445	H16_A0872	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
bktB	h16_A1290	H16_A1445	H16_A1290	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.650
bktB	h16_A1297	H16_A1445	H16_A1297	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase.	0.600
bktB	h16_A1528	H16_A1445	H16_A1528	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.689
bktB	h16_A1713	H16_A1445	H16_A1713	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.642
bktB	h16_A1720	H16_A1445	H16_A1720	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.663
bktB	h16_A1887	H16_A1445	H16_A1887	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.669
bktB	h16_A2148	H16_A1445	H16_A2148	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase.	0.600
bktB	h16_B0381	H16_A1445	H16_B0381	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.699
bktB	h16_B0406	H16_A1445	H16_B0406	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase.	0.600
bktB	h16_B0662	H16_A1445	H16_B0662	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.658
bktB	h16_B0668	H16_A1445	H16_B0668	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.656
bktB	h16_B0759	H16_A1445	H16_B0759	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.681
bktB	h16_B1369	H16_A1445	H16_B1369	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.661
bktB	pcaF	H16_A1445	H16_B0200	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.684
bktB	phaA	H16_A1445	H16_A1438	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB.	0.632

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