(15 nodes) Oxidoreductase activity, acting on a sulfur group of donors, and Ribonucleoside-diphosphate reductase complex network (Streptococcus sanguinis SK36)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	trxA2	Conserved hypothetical protein; GC: 43.75%; Codon Adaptation Index (CAI): 0.757. Curator(s): P. Manque; Protein involved in electron transport and cell redox homeostasis. (111 aa)
	tpx	Thiol peroxidase, putative; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (176 aa)
	SSA_0357	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family. (104 aa)
	msrB	Peptide methionine sulfoxide reductase msrA/msrB, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (311 aa)
	nrdF	Ribonucleoside-diphosphate reductase 2, beta subunit, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
	SSA_0769	Hypothetical protein; GC: 42.34%; Codon Adaptation Index (CAI): 0.774. Curator(s): X. Ge. (36 aa)
	nrdE	Ribonucleoside-diphosphate reductase, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (719 aa)
	nrdH	Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis. (72 aa)
	SSA_0813	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity. (322 aa)
	msrA	Peptide methionine sulfoxide reductase, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (369 aa)
	SSA_1288	Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves. (160 aa)
	basA	Glutathione peroxidase, putative; GC: 43.46%; Codon Adaptation Index (CAI): 0.8. Curator(s): J. Alves; Protein involved in oxidoreductase activity; Belongs to the glutathione peroxidase family. (157 aa)
	gor	Glutathione reductase, putative; GC: 45.01%; Codon Adaptation Index (CAI): 0.79; Protein involved in FAD binding. (513 aa)
	SSA_1865	Thioredoxin reductase, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.781; Protein involved in removal of superoxide radicals. (304 aa)
	nrdI	Ribonucleotide reductase (NrdI family protein), putative; GC: 43.56%; Codon Adaptation Index (CAI): 0.824. Curator(s): J. Alves; Belongs to the NrdI family. (162 aa)

Your Current Organism:

Streptococcus sanguinis SK36

NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SSA_0357	SSA_0813	SSA_0357	SSA_0813	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	0.612
SSA_0357	SSA_1865	SSA_0357	SSA_1865	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	Thioredoxin reductase, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.781; Protein involved in removal of superoxide radicals.	0.771
SSA_0357	basA	SSA_0357	SSA_1523	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	Glutathione peroxidase, putative; GC: 43.46%; Codon Adaptation Index (CAI): 0.8. Curator(s): J. Alves; Protein involved in oxidoreductase activity; Belongs to the glutathione peroxidase family.	0.500
SSA_0357	msrA	SSA_0357	SSA_1118	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	Peptide methionine sulfoxide reductase, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.642
SSA_0357	msrB	SSA_0357	SSA_0374	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	Peptide methionine sulfoxide reductase msrA/msrB, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.642
SSA_0769	nrdE	SSA_0769	SSA_0770	Hypothetical protein; GC: 42.34%; Codon Adaptation Index (CAI): 0.774. Curator(s): X. Ge.	Ribonucleoside-diphosphate reductase, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.661
SSA_0769	nrdF	SSA_0769	SSA_0768	Hypothetical protein; GC: 42.34%; Codon Adaptation Index (CAI): 0.774. Curator(s): X. Ge.	Ribonucleoside-diphosphate reductase 2, beta subunit, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.	0.768
SSA_0769	nrdH	SSA_0769	SSA_0771	Hypothetical protein; GC: 42.34%; Codon Adaptation Index (CAI): 0.774. Curator(s): X. Ge.	Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis.	0.410
SSA_0813	SSA_0357	SSA_0813	SSA_0357	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Thioredoxin, putative; GC: 45.71%; Codon Adaptation Index (CAI): 0.802. Curator(s): T. Kitten; Protein involved in electron transport; Belongs to the thioredoxin family.	0.612
SSA_0813	msrA	SSA_0813	SSA_1118	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Peptide methionine sulfoxide reductase, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.471
SSA_0813	msrB	SSA_0813	SSA_0374	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Peptide methionine sulfoxide reductase msrA/msrB, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.471
SSA_0813	nrdE	SSA_0813	SSA_0770	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Ribonucleoside-diphosphate reductase, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.601
SSA_0813	nrdF	SSA_0813	SSA_0768	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Ribonucleoside-diphosphate reductase 2, beta subunit, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.	0.656
SSA_0813	nrdH	SSA_0813	SSA_0771	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis.	0.796
SSA_0813	nrdI	SSA_0813	SSA_2263	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Ribonucleotide reductase (NrdI family protein), putative; GC: 43.56%; Codon Adaptation Index (CAI): 0.824. Curator(s): J. Alves; Belongs to the NrdI family.	0.671
SSA_0813	trxA2	SSA_0813	SSA_0211	Thioredoxin reductase, putative; GC: 47.57%; Codon Adaptation Index (CAI): 0.781. Curator(s): X. Ge; Protein involved in oxidoreductase activity.	Conserved hypothetical protein; GC: 43.75%; Codon Adaptation Index (CAI): 0.757. Curator(s): P. Manque; Protein involved in electron transport and cell redox homeostasis.	0.661
SSA_1288	msrA	SSA_1288	SSA_1118	Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves.	Peptide methionine sulfoxide reductase, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.462
SSA_1288	msrB	SSA_1288	SSA_0374	Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves.	Peptide methionine sulfoxide reductase msrA/msrB, putative; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.462
SSA_1288	nrdH	SSA_1288	SSA_0771	Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves.	Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis.	0.573
SSA_1288	trxA2	SSA_1288	SSA_0211	Conserved hypothetical protein; GC: 30.23%; Codon Adaptation Index (CAI): 0.74. Curator(s): J. Alves.	Conserved hypothetical protein; GC: 43.75%; Codon Adaptation Index (CAI): 0.757. Curator(s): P. Manque; Protein involved in electron transport and cell redox homeostasis.	0.724