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Tmel_0102 Tmel_0102 Tmel_0103 Tmel_0103 Tmel_0104 Tmel_0104 Tmel_0105 Tmel_0105 Tmel_0158 Tmel_0158 eno eno deoC deoC Tmel_0340 Tmel_0340 Tmel_0341 Tmel_0341 Tmel_0342 Tmel_0342 Tmel_0343 Tmel_0343 Tmel_0573 Tmel_0573 Tmel_0676 Tmel_0676 Tmel_0757 Tmel_0757 Tmel_0798 Tmel_0798 pfp pfp Tmel_0866 Tmel_0866 Tmel_0922 Tmel_0922 Tmel_1141 Tmel_1141 Tmel_1182 Tmel_1182 Tmel_1237 Tmel_1237 tpiA tpiA pgk pgk Tmel_1266 Tmel_1266 ackA ackA Tmel_1272 Tmel_1272 Tmel_1525 Tmel_1525 Tmel_1535 Tmel_1535 pfkA pfkA tal tal Tmel_1753 Tmel_1753 Tmel_1767 Tmel_1767 Tmel_1768 Tmel_1768 Tmel_1830 Tmel_1830 Tmel_1834 Tmel_1834 pgi pgi Tmel_1864 Tmel_1864 Tmel_1870 Tmel_1870 Tmel_1871 Tmel_1871 Tmel_1896 Tmel_1896 Tmel_1897 Tmel_1897 Tmel_1898 Tmel_1898 Tmel_1902 Tmel_1902
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tmel_0102PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (178 aa)
Tmel_0103PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding. (250 aa)
Tmel_0104PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (352 aa)
Tmel_0105PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (73 aa)
Tmel_0158TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing enzyme; pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; Belongs to the PEP-utilizing enzyme family. (881 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (241 aa)
Tmel_0340TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (191 aa)
Tmel_0341TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (110 aa)
Tmel_0342PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (392 aa)
Tmel_0343PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding. (325 aa)
Tmel_0573Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III. (474 aa)
Tmel_0676PFAM: PfkB domain protein; Belongs to the carbohydrate kinase PfkB family. (317 aa)
Tmel_0757PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III. (574 aa)
Tmel_0798Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (195 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (394 aa)
Tmel_0866TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein. (338 aa)
Tmel_0922TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. (470 aa)
Tmel_1141PFAM: ROK family protein. (308 aa)
Tmel_1182TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (145 aa)
Tmel_1237Hypothetical protein. (540 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (240 aa)
pgkPFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
Tmel_1266TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa)
Tmel_1272TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase, class-II. (311 aa)
Tmel_1525PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
Tmel_1535PFAM: mannose-6-phosphate isomerase, type I. (262 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
Tmel_1753PFAM: Transketolase domain protein; Transketolase, central region. (618 aa)
Tmel_1767PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding. (274 aa)
Tmel_1768TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (200 aa)
Tmel_1830PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (441 aa)
Tmel_1834PFAM: PfkB domain protein; Belongs to the carbohydrate kinase PfkB family. (306 aa)
pgiPFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (450 aa)
Tmel_1864Conserved carboxylase region; PFAM: pyruvate carboxyltransferase; Conserved carboxylase region. (458 aa)
Tmel_1870Succinate--CoA ligase (ADP-forming); PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein. (338 aa)
Tmel_1871PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase. (280 aa)
Tmel_1896PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (386 aa)
Tmel_1897PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (75 aa)
Tmel_1898TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit. (378 aa)
Tmel_19026-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (335 aa)
Your Current Organism:
Thermosipho melanesiensis
NCBI taxonomy Id: 391009
Other names: T. melanesiensis BI429, Thermosipho melanesiensis BI429, Thermosipho melanesiensis str. BI429, Thermosipho melanesiensis strain BI429
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