STRINGSTRING
SFR31402.1 SFR31402.1 purA purA ftsH ftsH thyA thyA SFR32742.1 SFR32742.1 SFR33304.1 SFR33304.1 gmk gmk SFR35332.1 SFR35332.1 SFR35338.1 SFR35338.1 SFR35389.1 SFR35389.1 dut dut tdk tdk SFR38990.1 SFR38990.1 SFR39136.1 SFR39136.1 der der SFR44998.1 SFR44998.1 SFR45006.1 SFR45006.1 SFR47392.1 SFR47392.1 SFR48049.1 SFR48049.1 cmk cmk guaB guaB apt apt SFR52211.1 SFR52211.1 adk adk SFR54496.1 SFR54496.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFR31402.1Uridine kinase. (202 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
ftsHCell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (667 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
SFR32742.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (191 aa)
SFR33304.1Inosine-uridine nucleoside N-ribohydrolase. (302 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (192 aa)
SFR35332.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (829 aa)
SFR35338.1Ribonucleoside-diphosphate reductase beta chain. (328 aa)
SFR35389.1dCMP deaminase. (150 aa)
dutdUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
tdkThymidine kinase. (215 aa)
SFR38990.1Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. (298 aa)
SFR39136.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
derGTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (433 aa)
SFR44998.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (304 aa)
SFR45006.15'-nucleotidase, C-terminal domain. (258 aa)
SFR47392.1Uridine phosphorylase. (295 aa)
SFR48049.1Adenosine kinase. (327 aa)
cmkCytidylate kinase. (234 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
SFR52211.1Adenosine deaminase. (327 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (371 aa)
SFR54496.1Cytidine deaminase. (160 aa)
Your Current Organism:
Robiginitalea myxolifaciens
NCBI taxonomy Id: 400055
Other names: DSM 21019, Flavobacteriaceae bacterium YM6-073, KCTC 22216, MBIC 06409, R. myxolifaciens, Robiginitalea myxolifaciens Manh et al. 2008, strain YM6-073
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