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| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1112 aa) |
| | SIS50531.1 | Predicted amidohydrolase. (291 aa) |
| | SIS51830.1 | NADP-dependent aldehyde dehydrogenase. (509 aa) |
| | SIS51845.1 | 5-dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (301 aa) |
| | SIS51861.1 | Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (305 aa) |
| | SIS53061.1 | Glutamate--putrescine ligase; Belongs to the glutamine synthetase family. (443 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (277 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | SIS53616.1 | Aromatic amino acid aminotransferase apoenzyme. (393 aa) |
| | SIS53629.1 | Thiosulfate/3-mercaptopyruvate sulfurtransferase. (284 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | SIS54498.1 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. (366 aa) |
| | SIS54512.1 | Carboxynorspermidine dehydrogenase. (408 aa) |
| | SIS54622.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | SIS54637.1 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (402 aa) |
| | SIS55708.1 | Aspartate kinase; Belongs to the aspartokinase family. (418 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | SIS57661.1 | Histidinol-phosphate aminotransferase. (369 aa) |
| | SIS57846.1 | Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (384 aa) |
| | SIS57883.1 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (292 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | SIS58171.1 | Hypothetical protein. (143 aa) |
| | SIS58186.1 | Aspartate aminotransferase. (371 aa) |
| | SIS58211.1 | L-glutamine synthetase. (452 aa) |
| | SIS58231.1 | Gamma-glutamylputrescine oxidase. (436 aa) |
| | SIS58799.1 | Aspartate/methionine/tyrosine aminotransferase. (397 aa) |
| | SIS64025.1 | Protein-disulfide isomerase. (249 aa) |
| | SIS64036.1 | Aspartate/methionine/tyrosine aminotransferase. (377 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (238 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (109 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (408 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (213 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | SIS64892.1 | Homoserine dehydrogenase. (429 aa) |
| | SIS64924.1 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (348 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (370 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (263 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (378 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (308 aa) |
| | SIS62496.1 | 5-aminolevulinate synthase. (409 aa) |
| | SIS70259.1 | Pyrroline-5-carboxylate reductase. (261 aa) |
| | SIS70359.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (292 aa) |
| | SIS71193.1 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | SIS72145.1 | Anthranilate synthase, component II. (196 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (501 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (395 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (270 aa) |
| | SIS72787.1 | L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1147 aa) |
| | SIS72832.1 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (390 aa) |
| | SIS69382.1 | Methionine-gamma-lyase. (399 aa) |
| | SIS68949.1 | Shikimate dehydrogenase. (277 aa) |
| | SIS69926.1 | Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase. (497 aa) |
| | SIS75120.1 | Adenosylhomocysteinase. (82 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (382 aa) |
| | SIS77454.1 | Glutamate synthase (NADPH) small subunit. (494 aa) |
| | SIS77483.1 | Glutamate synthase (NADPH) large subunit. (1512 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa) |
| | SIS76072.1 | Glutamate synthase domain-containing protein 2; Belongs to the glutamate synthase family. (548 aa) |
| | SIS76117.1 | L-threonine synthase. (460 aa) |
| | SIS80367.1 | Cytosine/adenosine deaminase. (450 aa) |
| | SIS80389.1 | Ornithine cyclodeaminase. (320 aa) |
| | SIS80404.1 | D-3-hydroxyaspartate aldolase. (387 aa) |
| | SIS80415.1 | Threonine dehydratase. (315 aa) |
| | SIS80424.1 | Serine-glyoxylate aminotransferase apoenzyme. (395 aa) |
| | SIS80441.1 | Transcriptional regulator, IclR family. (267 aa) |
| | SIS80721.1 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (475 aa) |
| | SIS81006.1 | Chorismate mutase. (98 aa) |
| | SIS81270.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (311 aa) |
| | SIS81608.1 | L-asparaginase. (511 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | SIS81818.1 | Succinyl-diaminopimelate desuccinylase. (422 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (118 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | SIS84236.1 | Protein N-acetyltransferase, RimJ/RimL family. (337 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | SIS85342.1 | Prephenate dehydratase. (281 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa) |
| | SIS83432.1 | Prephenate dehydrogenase. (307 aa) |
| | SIS83853.1 | Cysteine synthase A. (343 aa) |
| | SIS87835.1 | Prephenate dehydrogenase. (237 aa) |
| | SIS87882.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (903 aa) |
| | SIS87892.1 | Methionine synthase (B12-dependent). (347 aa) |
| | SIS88016.1 | Aspartate aminotransferase. (400 aa) |
| | SIS88118.1 | Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (390 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa) |
| | SIS88328.1 | Transcriptional regulator, MarR family. (162 aa) |
| | SIS88340.1 | Predicted amidohydrolase. (288 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | SIS88969.1 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (292 aa) |
| | SIS88978.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (358 aa) |
| | SIS88990.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (891 aa) |
| | metK-2 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (394 aa) |
| | SIS89012.1 | Adenosylhomocysteinase. (47 aa) |
| | SIS87222.1 | Aminodeoxychorismate synthase, subunit I. (375 aa) |
| | SIS87233.1 | 4-amino-4-deoxychorismate lyase. (213 aa) |
| | SIS91395.1 | L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1135 aa) |
| | SIS90163.1 | Proline racemase; Belongs to the proline racemase family. (343 aa) |
| | SIS90312.1 | Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family. (134 aa) |
| | SIS90320.1 | Aspartate/methionine/tyrosine aminotransferase. (403 aa) |
| | SIS89896.1 | Succinyl-diaminopimelate desuccinylase. (393 aa) |
| | SIS94066.1 | Agmatinase; Belongs to the arginase family. (323 aa) |
| | SIS94081.1 | Gamma-glutamylputrescine oxidase. (436 aa) |
| | SIS94092.1 | Glutamate--putrescine ligase; Belongs to the glutamine synthetase family. (449 aa) |
| | SIS94122.1 | Acetylornithine deacetylase. (429 aa) |
| | SIS98680.1 | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (226 aa) |
| | SIS98689.1 | ATP phosphoribosyltransferase regulatory subunit. (352 aa) |
| | hisS | histidyl-tRNA synthetase. (494 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | SIT00626.1 | Arginase; Belongs to the arginase family. (306 aa) |
| | SIT00941.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (470 aa) |
| | SIT01011.1 | Serine O-acetyltransferase. (275 aa) |
| | SIT01353.1 | Chorismate mutase. (131 aa) |
| | SIT03809.1 | Cystathione beta-lyase. (394 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | SIT03883.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa) |
| | argH | Argininosuccinate lyase. (468 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | SIT05454.1 | Ornithine cyclodeaminase. (319 aa) |
| | SIT04514.1 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa) |
| | SIT06255.1 | Ornithine cyclodeaminase. (300 aa) |
| | SIT07739.1 | Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (544 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | SIT10425.1 | Phosphoserine phosphatase. (292 aa) |
| | SIT10816.1 | Adenosylhomocysteinase. (82 aa) |
| | SIT10831.1 | Sugar or nucleoside kinase, ribokinase family. (330 aa) |
| | SIT10842.1 | Hypothetical protein. (67 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | SIT10864.1 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. (286 aa) |
| | SIT11544.1 | L-glutamine synthetase. (468 aa) |
| | SIT12308.1 | Aspartate aminotransferase. (402 aa) |
| | SIT14844.1 | Cysteine synthase A. (212 aa) |
| | SIT15566.1 | Argininosuccinate lyase. (520 aa) |
| | SIT16402.1 | Serine O-acetyltransferase. (260 aa) |
| | SIT19167.1 | Adenosylhomocysteinase. (403 aa) |
