STRINGSTRING
ENSSDUP00000017713 ENSSDUP00000017713 dna2 dna2 ENSSDUP00000000054 ENSSDUP00000000054 ENSSDUP00000000081 ENSSDUP00000000081 ENSSDUP00000000783 ENSSDUP00000000783 ENSSDUP00000001025 ENSSDUP00000001025 ENSSDUP00000001040 ENSSDUP00000001040 ENSSDUP00000001199 ENSSDUP00000001199 exd2 exd2 ankrd28 ankrd28 tert tert RTEL1 RTEL1 gar1 gar1 H2AZ1 H2AZ1 terf2 terf2 pola1 pola1 chtf8 chtf8 pcna pcna ENSSDUP00000004600 ENSSDUP00000004600 prim2 prim2 nhp2 nhp2 ENSSDUP00000032464 ENSSDUP00000032464 ENSSDUP00000032462 ENSSDUP00000032462 rfc2 rfc2 rfc4 rfc4 prim1 prim1 rfc1 rfc1 wrap53 wrap53 pold2 pold2 ENSSDUP00000029876 ENSSDUP00000029876 LOC111222185 LOC111222185 ENSSDUP00000029566 ENSSDUP00000029566 LOC111237550 LOC111237550 lig1 lig1 ENSSDUP00000027840 ENSSDUP00000027840 LOC111221153 LOC111221153 ENSSDUP00000027664 ENSSDUP00000027664 LOC111227991 LOC111227991 ten1 ten1 ruvbl2 ruvbl2 fen1 fen1 LOC111230957 LOC111230957 ankrd44 ankrd44 rfc5 rfc5 chtf18 chtf18 pold1 pold1 dscc1 dscc1 trub1 trub1 ENSSDUP00000022505 ENSSDUP00000022505 ENSSDUP00000022496 ENSSDUP00000022496 RPA1 RPA1 ENSSDUP00000022255 ENSSDUP00000022255 ENSSDUP00000022246 ENSSDUP00000022246 pola2 pola2 ENSSDUP00000022019 ENSSDUP00000022019 ENSSDUP00000021879 ENSSDUP00000021879 ENSSDUP00000021729 ENSSDUP00000021729 LOC111221050 LOC111221050 ENSSDUP00000021478 ENSSDUP00000021478 stn1 stn1 ENSSDUP00000006989 ENSSDUP00000006989 LOC111221313 LOC111221313 ENSSDUP00000007129 ENSSDUP00000007129 ENSSDUP00000007300 ENSSDUP00000007300 ENSSDUP00000007804 ENSSDUP00000007804 meiob meiob atrx atrx pold4 pold4 tinf2 tinf2 LOC111223067 LOC111223067 RCBTB1 RCBTB1 LOC111225623 LOC111225623 ccna2 ccna2 daxx daxx ctc1 ctc1 rpa2 rpa2 pold3 pold3 ENSSDUP00000013391 ENSSDUP00000013391 dkc1 dkc1 ENSSDUP00000014654 ENSSDUP00000014654 blm blm LOC111228832 LOC111228832 ENSSDUP00000016000 ENSSDUP00000016000 cdk2 cdk2 rpa1 rpa1 shq1 shq1 ENSSDUP00000021373 ENSSDUP00000021373 terf2ip terf2ip pot1 pot1 nop10 nop10 rfc3 rfc3 ENSSDUP00000019855 ENSSDUP00000019855 ccna1 ccna1 PPP6C PPP6C ENSSDUP00000018777 ENSSDUP00000018777 ENSSDUP00000018600 ENSSDUP00000018600 ENSSDUP00000018517 ENSSDUP00000018517 ENSSDUP00000018183 ENSSDUP00000018183 LOC111221389 LOC111221389 rpa3 rpa3 rcbtb2 rcbtb2 ENSSDUP00000017647 ENSSDUP00000017647 terf1 terf1 pif1 pif1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSDUP00000017713annotation not available (93 aa)
dna2DNA replication helicase/nuclease 2. (1406 aa)
ENSSDUP00000000054Histone H2B; Belongs to the histone H2B family. (131 aa)
ENSSDUP00000000081Histone H2A; Belongs to the histone H2A family. (142 aa)
ENSSDUP00000000783Histone H2A; Belongs to the histone H2A family. (143 aa)
ENSSDUP00000001025Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSSDUP00000001040Uncharacterized protein; Belongs to the histone H2B family. (67 aa)
ENSSDUP00000001199Histone H2A; Belongs to the histone H2A family. (133 aa)
exd2Exonuclease 3'-5' domain containing 2. (625 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1108 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1035 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (240 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (154 aa)
terf2HTH myb-type domain-containing protein. (641 aa)
pola1DNA polymerase. (1474 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (106 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSSDUP00000004600Uncharacterized protein. (578 aa)
prim2DNA primase subunit 2. (592 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
ENSSDUP00000032464Histone H2A; Belongs to the histone H2A family. (127 aa)
ENSSDUP00000032462Histone H2A; Belongs to the histone H2A family. (126 aa)
rfc2Replication factor C (activator 1) 2. (387 aa)
rfc4Replication factor C (activator 1) 4. (359 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (423 aa)
rfc1Replication factor C subunit 1. (1181 aa)
wrap53WD repeat containing, antisense to TP53. (559 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (491 aa)
ENSSDUP00000029876Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
LOC111222185Histone H2A; Belongs to the histone H2A family. (140 aa)
ENSSDUP00000029566Histone H2B; Belongs to the histone H2B family. (114 aa)
LOC111237550Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
lig1DNA ligase. (616 aa)
ENSSDUP00000027840Uncharacterized protein; Belongs to the histone H2B family. (117 aa)
LOC111221153Serine/threonine-protein phosphatase. (305 aa)
ENSSDUP00000027664Histone_H2A_C domain-containing protein. (155 aa)
LOC111227991Histone H2A; Belongs to the histone H2A family. (165 aa)
ten1TEN1 subunit of CST complex. (132 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC111230957Histone H2B; Belongs to the histone H2B family. (124 aa)
ankrd44Ankyrin repeat domain 44. (996 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (877 aa)
pold1DNA polymerase. (1121 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (278 aa)
ENSSDUP00000022505Histone domain-containing protein; Belongs to the histone H2B family. (121 aa)
ENSSDUP00000022496Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa)
ENSSDUP00000022255Histone H2A; Belongs to the histone H2A family. (139 aa)
ENSSDUP00000022246Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
ENSSDUP00000022019Histone domain-containing protein; Belongs to the histone H2B family. (116 aa)
ENSSDUP00000021879Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSSDUP00000021729Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
LOC111221050Histone H2A; Belongs to the histone H2A family. (136 aa)
ENSSDUP00000021478Histone H2B; Belongs to the histone H2B family. (116 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
ENSSDUP00000006989Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC111221313Histone H2B; Belongs to the histone H2B family. (123 aa)
ENSSDUP00000007129Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSSDUP00000007300Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
ENSSDUP00000007804Histone H2A; Belongs to the histone H2A family. (130 aa)
meiobMethionine sulfoxide reductase B1b. (472 aa)
atrxATRX chromatin remodeler. (2058 aa)
pold4Si:dkey-28b4.7. (108 aa)
tinf2TINF2_N domain-containing protein. (558 aa)
LOC111223067ANK_REP_REGION domain-containing protein. (1056 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC111225623Ankyrin repeat domain 66. (213 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (437 aa)
daxxDeath-domain associated protein. (753 aa)
ctc1Uncharacterized protein. (1202 aa)
rpa2Replication protein A2. (278 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
ENSSDUP00000013391Histone H2A; Belongs to the histone H2A family. (134 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (502 aa)
ENSSDUP00000014654Histone H2A; Belongs to the histone H2A family. (126 aa)
blmBLM RecQ like helicase. (1392 aa)
LOC111228832Zgc:110269. (344 aa)
ENSSDUP00000016000RPA_C domain-containing protein. (250 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (611 aa)
ENSSDUP00000021373Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
terf2ipBRCT domain-containing protein. (667 aa)
pot1Protection of telomeres 1 homolog. (811 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSSDUP00000019855Uncharacterized protein. (1743 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (410 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
ENSSDUP00000018777Histone H2A; Belongs to the histone H2A family. (134 aa)
ENSSDUP00000018600Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSSDUP00000018517Histone H2A; Belongs to the histone H2A family. (140 aa)
ENSSDUP00000018183RecQ helicase-like 4. (749 aa)
LOC111221389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rpa3Replication protein A3. (122 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
ENSSDUP00000017647Histone H2B; Belongs to the histone H2B family. (139 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (362 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (631 aa)
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
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