STRINGSTRING
kif8 kif8 racG racG racF2 racF2 kif1 kif1 dct dct racB racB racA racA rac1C rac1C rac1B rac1B rac1A rac1A cdk1 cdk1 cofA cofA arpB arpB racF1 racF1 rabif rabif racO racO kif12 kif12 PLK PLK racL racL racJ racJ racI racI racH racH racN racN RacP RacP racM racM ctxA ctxA racE racE racQ racQ racD racD racC racC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kif8Kinesin-related protein 8; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with kif10 and dynein to organize interphase microtubules. (1873 aa)
racGRho-related protein racG. (201 aa)
racF2Rho-related protein racF2. (193 aa)
kif1Kinesin-related protein 1; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end. Transports cytoplasmic vesicles and particularly phosphatidylinositol 4,5-bisphosphate-containing liposomes along microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. (2205 aa)
dctDynacortin. (354 aa)
racBRho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa)
racARho-related protein racA. (598 aa)
rac1CRho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa)
rac1BRho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa)
rac1ARho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa)
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)
cofACofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
arpBActin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (392 aa)
racF1Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa)
rabifMss4-like family protein. (163 aa)
racORho-related protein racO. (276 aa)
kif12Kinesin-related protein 12; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Required for cytokinesis. May be involved in a vesicle-mediated transport of myosin II, the Aurora kinase (aurK) and other proteins along mitotic extracellular microtubules toward the center of the cell and the cleavage furrow in order to ensure cell division coupled to mitosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1499 aa)
PLKProbable serine/threonine-protein kinase PLK; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (978 aa)
racLRho-related protein racL. (196 aa)
racJRho-related protein racJ. (205 aa)
racIRho-related protein racI. (205 aa)
racHRho-related protein racH. (200 aa)
racNRho-related protein racN. (219 aa)
RacPRho GTPase. (376 aa)
racMRho-related protein racM. (189 aa)
ctxACortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa)
racERho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa)
racQRho GTPase. (185 aa)
racDRho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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