STRINGSTRING
Aasi_1949 Aasi_1949 Aasi_1875 Aasi_1875 Aasi_1805 Aasi_1805 Aasi_1779 Aasi_1779 Aasi_1629 Aasi_1629 Aasi_1504 Aasi_1504 tuf tuf nusG nusG rplA rplA recX recX Aasi_1160 Aasi_1160 Aasi_1128 Aasi_1128 Aasi_1097 Aasi_1097 prfB prfB Aasi_1035 Aasi_1035 Aasi_0999 Aasi_0999 lepA lepA Aasi_0893 Aasi_0893 Aasi_0838 Aasi_0838 Aasi_0789 Aasi_0789 Aasi_0770 Aasi_0770 Aasi_0749 Aasi_0749 greA greA efp efp prfA prfA Aasi_0662 Aasi_0662 dacA dacA Aasi_0637 Aasi_0637 Aasi_0624 Aasi_0624 Aasi_0605 Aasi_0605 Aasi_0580 Aasi_0580 infC infC Aasi_0529 Aasi_0529 Aasi_0528 Aasi_0528 Aasi_0442 Aasi_0442 Aasi_0435 Aasi_0435 Aasi_0422 Aasi_0422 Aasi_0340 Aasi_0340 Aasi_0286 Aasi_0286 mfd mfd Aasi_0269 Aasi_0269 Aasi_0268 Aasi_0268 Aasi_0262 Aasi_0262 rsfS rsfS infA infA Aasi_0154 Aasi_0154 infB infB nusA nusA fusA fusA Aasi_0087 Aasi_0087 tsf tsf Aasi_0019 Aasi_0019 Aasi_0014 Aasi_0014 Aasi_0009 Aasi_0009 dnaA dnaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Aasi_1949Hypothetical protein. (802 aa)
Aasi_1875Hypothetical protein. (154 aa)
Aasi_1805Hypothetical protein. (339 aa)
Aasi_1779Hypothetical protein. (60 aa)
Aasi_1629Hypothetical protein. (2279 aa)
Aasi_1504Hypothetical protein; PRINTS: PR00338, Transcription antitermination protein, NusG; SUPERFAMILY: SSF50104, Translation protein SH3-like;SSF82679, Transcription antitermination protein, NusG, N-terminal; PFAM: PF00467, KOW;PF02357, Transcription antitermination protein, NusG, N-terminal; PRODOM: PD005267, Transcription antitermination protein, NusG, archaea; GENE3D: G3DSA:2.30.30.30, Translation protein SH3-like, subgroup;G3DSA:3.30.70.940, Transcription antitermination protein, NusG, N-terminal; SMART: SM00739, KOW;SM00738, Transcription antitermination protein, NusG, N-terminal; TIGRF [...] (270 aa)
tufHypothetical protein; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
nusGHypothetical protein; Participates in transcription elongation, termination and antitermination. (186 aa)
rplAHypothetical protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (232 aa)
recXHypothetical protein; Modulates RecA activity; Belongs to the RecX family. (160 aa)
Aasi_1160Hypothetical protein; PROSITE: PS01150, NADH dehydrogenase (ubiquinone), 20 kDa subunit; PANTHER: PTHR11995:SF2, NADH dehydrogenase (ubiquinone), 20 kDa subunit;PTHR11995, [NiFe]-hydrogenase-3-type complex, small subunit/NADH:quinone oxidoreductase, subunit NuoB; PFAM: PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit; TIGRFAMS: TIGR01957, NADH dehydrogenase (ubiquinone), 20 kDa subunit. (2303 aa)
Aasi_1128Hypothetical protein; SMART: SM00368, Leucine-rich repeat, ribonuclease inhibitor subtype; Belongs to the multicopper oxidase YfiH/RL5 family. (278 aa)
Aasi_1097Hypothetical protein; PROSITE: PS00211, ABC transporter-like; PROFILE: PS50893, ABC transporter-like; PFAM: PF00005, ABC transporter-like; PRODOM: PD000006, ABC transporter-like; SMART: SM00382, AAA+ ATPase, core. (197 aa)
prfBHypothetical protein; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (332 aa)
Aasi_1035Hypothetical protein; PFAM: PF01797, Transposase IS200-like; PRODOM: PD003831, Transposase IS200-like. (220 aa)
Aasi_0999Hypothetical protein; PFAM: PF01609, Transposase, IS4-like. (2272 aa)
lepAHypothetical protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (595 aa)
Aasi_0893Hypothetical protein; PFAM: PF01609, Transposase, IS4-like. (130 aa)
Aasi_0838Hypothetical protein; PROSITE: PS01096, Peptidyl-prolyl cis-trans isomerase, PpiC-type; PROFILE: PS50198, Peptidyl-prolyl cis-trans isomerase, PpiC-type; PFAM: PF09312, SurA N-terminal domain;PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type. (229 aa)
Aasi_0789Hypothetical protein; PRINTS: PR00477, Phosphoglycerate kinase; PANTHER: PTHR11406, Phosphoglycerate kinase; SUPERFAMILY: SSF53748, Phosphoglycerate kinase; PFAM: PF00162, Phosphoglycerate kinase; GENE3D: G3DSA:3.40.50.1270, Phosphoglycerate kinase, C-terminal;G3DSA:3.40.50.1260, Phosphoglycerate kinase, N-terminal. (479 aa)
Aasi_0770Hypothetical protein. (343 aa)
Aasi_0749Hypothetical protein; PFAM: PF00924, Mechanosensitive ion channel MscS; SUPERFAMILY: SSF50182, Like-Sm ribonucleoprotein-related, core;SSF82689, Mechanosensitive ion channel MscS, C-terminal;SSF82861, Mechanosensitive ion channel MscS, transmembrane-2. (271 aa)
greAHypothetical protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (157 aa)
efpHypothetical protein; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (190 aa)
prfAHypothetical protein; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa)
Aasi_0662PFAM: PF03811, Insertion element protein; SUPERFAMILY: SSF46689, Homeodomain-like. (163 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (264 aa)
Aasi_0637Hypothetical protein; SUPERFAMILY: SSF53623, Mur ligase, central;SSF53244, Mur ligase, C-terminal; PFAM: PF08245, Mur ligase, central;PF01225, Mur ligase, N-terminal;PF02875, Mur ligase, C-terminal; GENE3D: G3DSA:3.40.1190.10, Mur ligase, central;G3DSA:3.90.190.20, Mur ligase, C-terminal; TIGRFAMS: TIGR01085, UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase. (67 aa)
Aasi_0624Hypothetical protein; PROFILE: PS50937, Bacterial regulatory protein, MerR; PFAM: PF00376, Bacterial regulatory protein, MerR; SUPERFAMILY: SSF46955, Putative DNA binding; SMART: SM00422, Bacterial regulatory protein, MerR. (244 aa)
Aasi_0605PRINTS: PR00064, Ribosomal protein L35; PROSITE: PS00936, Ribosomal protein L35; PFAM: PF01632, Ribosomal protein L35; PRODOM: PD003417, Ribosomal protein L35; TIGRFAMS: TIGR00001, Ribosomal protein L35. (426 aa)
Aasi_0580Hypothetical protein; PROSITE: PS00368, Ribonucleotide reductase; PANTHER: PTHR23409, Ribonucleotide reductase; PFAM: PF00268, Ribonucleotide reductase; SUPERFAMILY: SSF47240, Ferritin/ribonucleotide reductase-like; GENE3D: G3DSA:1.10.620.20, Ribonucleotide reductase-related. (109 aa)
infCHypothetical protein; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (186 aa)
Aasi_0529Hypothetical protein. (156 aa)
Aasi_0528Hypothetical protein. (107 aa)
Aasi_0442Hypothetical protein; PROFILE: PS50297, Ankyrin; SUPERFAMILY: SSF48403, Ankyrin. (326 aa)
Aasi_0435Hypothetical protein. (478 aa)
Aasi_0422Hypothetical protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (378 aa)
Aasi_0340Hypothetical protein; PRINTS: PR00868, DNA polymerase A; PROSITE: PS00447, DNA-directed DNA polymerase, family A; SUPERFAMILY: SSF53098, Polynucleotidyl transferase, Ribonuclease H fold;SSF47807, Helix-hairpin-helix motif, class 2; PFAM: PF01612, 3'-5' exonuclease;PF00476, DNA-directed DNA polymerase, family A;PF01367, 5'-3' exonuclease;PF02739, 5'-3' exonuclease; SMART: SM00474, 3'-5' exonuclease;SM00482, DNA-directed DNA polymerase, family A;SM00279, Helix-hairpin-helix motif, class 2;SM00475, 5'-3' exonuclease; TIGRFAMS: TIGR00593, DNA polymerase A. (2413 aa)
Aasi_0286Hypothetical protein; PROSITE: PS00096, Glycine hydroxymethyltransferase; PANTHER: PTHR11680, Glycine hydroxymethyltransferase; SUPERFAMILY: SSF53383, Pyridoxal phosphate-dependent transferase, major region; PFAM: PF00464, Glycine hydroxymethyltransferase; PIR: PIRSF000412, Glycine hydroxymethyltransferase; GENE3D: G3DSA:3.40.640.10, Pyridoxal phosphate-dependent transferase, major region, subdomain 1. (352 aa)
mfdHypothetical protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1123 aa)
Aasi_0269Hypothetical protein. (136 aa)
Aasi_0268PROSITE: PS00287, Proteinase inhibitor I25, cystatin; PROFILE: PS50994, Integrase, catalytic core; PFAM: PF00665, Integrase, catalytic core; SUPERFAMILY: SSF53098, Polynucleotidyl transferase, Ribonuclease H fold. (182 aa)
Aasi_0262Hypothetical protein. (134 aa)
rsfSHypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (122 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (76 aa)
Aasi_0154Histone family protein DNA-binding protein; PRINTS: PR01042, Aspartyl-tRNA synthetase, class IIb; PANTHER: PTHR22594, Aminoacyl-tRNA synthetase, class II (D, K and N);PTHR22594:SF5, Aspartyl-tRNA synthetase, class IIb, bacterial/mitochondrial type; PROFILE: PS50862, Aminoacyl-tRNA synthetase, class II; SUPERFAMILY: SSF50249, Nucleic acid-binding, OB-fold-like; PFAM: PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N);PF02938, GAD;PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type; GENE3D: G3DSA:2.40.50.140, Nucleic acid-binding, OB-fold; TIGRFAMS: TIGR00459, Aspartyl-tRNA [...] (95 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (908 aa)
nusATranscription termination factor NusA; Participates in both transcription termination and antitermination. (411 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (709 aa)
Aasi_0087Hypothetical protein; PFAM: PF02016, Peptidase S66, LD-carboxypeptidase A. (58 aa)
tsfTranslation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (277 aa)
Aasi_0019Appr-1-p processing domain protein; PRINTS: PR00781, Peptidase A8, signal peptidase II; PRODOM: PD004304, Peptidase A8, signal peptidase II. (283 aa)
Aasi_0014RNA polymerase sigma factor, sigma-70 family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (287 aa)
Aasi_0009Helix-turn-helix- domain containing protein AraC type. (315 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (477 aa)
Your Current Organism:
Amoebophilus asiaticus
NCBI taxonomy Id: 452471
Other names: C. Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus str. 5a2, Candidatus Amoebophilus asiaticus strain 5a2
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