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AJR22484.1 AJR22484.1 AJR22533.1 AJR22533.1 AJR22549.1 AJR22549.1 AJR22550.1 AJR22550.1 gcvPA gcvPA gcvH gcvH AJR26069.1 AJR26069.1 AJR22593.1 AJR22593.1 gabD gabD AJR22884.1 AJR22884.1 ppc ppc proA proA AJR23022.1 AJR23022.1 AJR23121.1 AJR23121.1 gabD-2 gabD-2 AJR23242.1 AJR23242.1 AJR23252.1 AJR23252.1 AJR23285.1 AJR23285.1 AJR26187.1 AJR26187.1 AJR23286.1 AJR23286.1 AJR23418.1 AJR23418.1 AJR23419.1 AJR23419.1 AJR26223.1 AJR26223.1 AJR26224.1 AJR26224.1 AJR23599.1 AJR23599.1 putA putA AJR23658.1 AJR23658.1 AJR23807.1 AJR23807.1 AJR23883.1 AJR23883.1 AJR23884.1 AJR23884.1 AJR23885.1 AJR23885.1 AJR26285.1 AJR26285.1 AJR26316.1 AJR26316.1 AJR24134.1 AJR24134.1 AJR24136.1 AJR24136.1 AJR26327.1 AJR26327.1 AJR24541.1 AJR24541.1 proB proB AJR24688.1 AJR24688.1 AJR24807.1 AJR24807.1 mdh mdh sucD sucD sucA sucA AJR24812.1 AJR24812.1 AJR24814.1 AJR24814.1 AJR24823.1 AJR24823.1 gltA gltA fumC fumC purU purU AJR25113.1 AJR25113.1 pdhA pdhA AJR25139.1 AJR25139.1 AJR25223.1 AJR25223.1 glcB glcB glsA glsA murI murI AJR25576.1 AJR25576.1 glnA glnA AJR25662.1 AJR25662.1 AJR25664.1 AJR25664.1 AJR25745.1 AJR25745.1 AJR25810.1 AJR25810.1 AJR26533.1 AJR26533.1 AJR25811.1 AJR25811.1 sucC sucC pckA pckA AJR26037.1 AJR26037.1 AJR26038.1 AJR26038.1 AJR26039.1 AJR26039.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJR22484.1Branched-chain alpha-keto acid dehydrogenase subunit E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (431 aa)
AJR22533.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1555 aa)
AJR22549.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
AJR22550.1Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
gcvPAGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (452 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
AJR26069.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
AJR22593.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
gabDSuccinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
AJR22884.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (506 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (899 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
AJR23022.1Carbamoyl phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
AJR23121.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
gabD-2Succinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJR23242.1Tricarballylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
AJR23252.1NADH:flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (662 aa)
AJR23285.1Dihydrolipoamide acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
AJR26187.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJR23286.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AJR23418.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
AJR23419.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
AJR26223.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
AJR26224.1Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
AJR23599.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (494 aa)
putATranscriptional regulator; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1200 aa)
AJR23658.1Acetamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AJR23807.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1109 aa)
AJR23883.1ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AJR23884.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
AJR23885.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (948 aa)
AJR26285.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
AJR26316.1Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AJR24134.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1512 aa)
AJR24136.1Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AJR26327.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
AJR24541.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
AJR24688.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
AJR24807.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucASucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (931 aa)
AJR24812.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (413 aa)
AJR24814.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
AJR24823.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
AJR25113.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (358 aa)
AJR25139.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (463 aa)
AJR25223.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (755 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (698 aa)
glsAGlutaminase; Catalyzes the formation of glutamate from glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (312 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (267 aa)
AJR25576.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (900 aa)
glnAForms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
AJR25662.1E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AJR25664.1Branched-chain alpha-keto acid dehydrogenase subunit E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (432 aa)
AJR25745.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (889 aa)
AJR25810.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AJR26533.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AJR25811.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (531 aa)
AJR26037.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (604 aa)
AJR26038.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
AJR26039.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
Your Current Organism:
Sphingobium sp. YBL2
NCBI taxonomy Id: 484429
Other names: S. sp. YBL2
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