(51 nodes) cAMP metabolic process, and 35-cyclic nucleotide phosphodiesterase, catalytic domain network (Poecilia mexicana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106914433	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1132 aa)
	LOC106906069	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
	LOC106917137	Phosphodiesterase. (673 aa)
	ADCY9	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1447 aa)
	ADCY9-2	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1439 aa)
	LOC106913875	Phosphodiesterase. (745 aa)
	pde4c	Phosphodiesterase. (805 aa)
	pde4d	Phosphodiesterase. (780 aa)
	ENSPMEP00000007572	Uncharacterized protein. (254 aa)
	LOC106926897	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1087 aa)
	LOC106920816	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	LOC106930772	Rap guanine nucleotide exchange factor (GEF) 4. (1022 aa)
	ENSPMEP00000010244	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (305 aa)
	LOC106927339	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1063 aa)
	LOC106904967	Rap guanine nucleotide exchange factor (GEF) 3. (868 aa)
	pde7a	Phosphodiesterase. (509 aa)
	pde8b	Phosphodiesterase 8B; Belongs to the cyclic nucleotide phosphodiesterase family. (355 aa)
	LOC106905188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1188 aa)
	LOC106928659	Phosphodiesterase. (899 aa)
	ENSPMEP00000013408	Guanylate cyclase domain-containing protein. (115 aa)
	LOC106928563	Guanylate cyclase. (809 aa)
	ENSPMEP00000015645	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (300 aa)
	LOC106905601	Zgc:171558. (881 aa)
	ENSPMEP00000016120	Uncharacterized protein. (107 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (983 aa)
	LOC106922633	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (829 aa)
	pde10a	Phosphodiesterase. (807 aa)
	pde6c	Phosphodiesterase. (855 aa)
	ENSPMEP00000018222	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (206 aa)
	ENSPMEP00000018891	PDEase domain-containing protein. (136 aa)
	ENSPMEP00000018905	PDEase domain-containing protein. (105 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
	LOC106927792	Phosphodiesterase. (1121 aa)
	PDE7B	Phosphodiesterase. (454 aa)
	LOC106928230	Phosphodiesterase. (849 aa)
	PDE3A	Phosphodiesterase. (680 aa)
	pde3b	Phosphodiesterase. (1096 aa)
	LOC106908871	NUC domain-containing protein. (658 aa)
	LOC106908136	Phosphodiesterase. (673 aa)
	LOC106919688	Phosphodiesterase. (845 aa)
	pde9a	Phosphodiesterase. (518 aa)
	LOC106919898	Guanine nucleotide binding protein (G protein), beta polypeptide 3b. (342 aa)
	LOC106932740	Phosphodiesterase. (746 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1108 aa)
	LOC106914961	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	LOC106928739	Phosphodiesterase. (871 aa)
	ENSPMEP00000029147	Si:dkey-219c10.4; Belongs to the cyclic nucleotide phosphodiesterase family. (360 aa)
	LOC106930565	Guanylate cyclase. (1081 aa)
	LOC106904132	Guanylate cyclase. (1033 aa)
	ENSPMEP00000032886	annotation not available (273 aa)
	ENSPMEP00000033408	Uncharacterized protein. (116 aa)

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY9	ENSPMEP00000007572	ENSPMEP00000004639	ENSPMEP00000007572	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.830
ADCY9	ENSPMEP00000010244	ENSPMEP00000004639	ENSPMEP00000010244	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.630
ADCY9	ENSPMEP00000013408	ENSPMEP00000004639	ENSPMEP00000013408	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.442
ADCY9	ENSPMEP00000015645	ENSPMEP00000004639	ENSPMEP00000015645	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.664
ADCY9	ENSPMEP00000016120	ENSPMEP00000004639	ENSPMEP00000016120	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.671
ADCY9	ENSPMEP00000018891	ENSPMEP00000004639	ENSPMEP00000018891	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein.	0.770
ADCY9	ENSPMEP00000018905	ENSPMEP00000004639	ENSPMEP00000018905	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein.	0.767
ADCY9	ENSPMEP00000029147	ENSPMEP00000004639	ENSPMEP00000029147	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Si:dkey-219c10.4; Belongs to the cyclic nucleotide phosphodiesterase family.	0.777
ADCY9	ENSPMEP00000032886	ENSPMEP00000004639	ENSPMEP00000032886	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	annotation not available	0.630
ADCY9	ENSPMEP00000033408	ENSPMEP00000004639	ENSPMEP00000033408	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.767
ADCY9	LOC106904132	ENSPMEP00000004639	ENSPMEP00000032398	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase.	0.425
ADCY9	LOC106904967	ENSPMEP00000004639	ENSPMEP00000010965	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Rap guanine nucleotide exchange factor (GEF) 3.	0.890
ADCY9	LOC106905188	ENSPMEP00000004639	ENSPMEP00000011766	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.664
ADCY9	LOC106905601	ENSPMEP00000004639	ENSPMEP00000016100	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Zgc:171558.	0.886
ADCY9	LOC106906069	ENSPMEP00000004639	ENSPMEP00000002585	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630
ADCY9	LOC106908136	ENSPMEP00000004639	ENSPMEP00000024526	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.823
ADCY9	LOC106908871	ENSPMEP00000004639	ENSPMEP00000023413	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	NUC domain-containing protein.	0.830
ADCY9	LOC106913875	ENSPMEP00000004639	ENSPMEP00000005667	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.879
ADCY9	LOC106914433	ENSPMEP00000004639	ENSPMEP00000001737	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.680
ADCY9	LOC106914961	ENSPMEP00000004639	ENSPMEP00000026690	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.630