STRINGSTRING
LOC106927467 LOC106927467 edn1 edn1 gbx2 gbx2 plxna4 plxna4 LOC106929094 LOC106929094 LOC106917549 LOC106917549 LOC106931238 LOC106931238 LOC106929752 LOC106929752 LOC106919996 LOC106919996 LOC106919274 LOC106919274 LOC106931781 LOC106931781 ppp3r1 ppp3r1 tcf21 tcf21 ENSPMEP00000029638 ENSPMEP00000029638 ilk ilk il10 il10 pkd1 pkd1 LOC106923514 LOC106923514 LOC106920767 LOC106920767 setd2 setd2 timeless timeless ENSPMEP00000026667 ENSPMEP00000026667 LOC106925627 LOC106925627 sars1 sars1 ILK ILK gdnf gdnf LOC106903221 LOC106903221 plxna1 plxna1 med1 med1 nrarp nrarp LOC106915081 LOC106915081 SMAD4 SMAD4 lrp6 lrp6 bcl2 bcl2 tmem59l tmem59l ctnnbip1 ctnnbip1 tmed2 tmed2 wnt6 wnt6 PLXNA2 PLXNA2 TGFBR2 TGFBR2 mks1 mks1 fem1b fem1b LOC106914502 LOC106914502 sema3a sema3a SOX9 SOX9 LOC106907692 LOC106907692 LOC106927838 LOC106927838 dlg5 dlg5 PRDM1 PRDM1 sfrp2 sfrp2 hhip hhip btbd7 btbd7 sox10 sox10 LOC106909302 LOC106909302 sox9 sox9 LOC106920633 LOC106920633 LOC106903560 LOC106903560 LOC106920679 LOC106920679 LOC106909474 LOC106909474 ctsh ctsh bmp2 bmp2 LOC106907870 LOC106907870 LOC106925465 LOC106925465 LOC106920166 LOC106920166 ENSPMEP00000010756 ENSPMEP00000010756 LOC106908804 LOC106908804 sema3c sema3c wt1 wt1 LOC106928804 LOC106928804 LOC106920283 LOC106920283 lef1 lef1 ar ar greb1 greb1 LOC106923072 LOC106923072 LOC106912208 LOC106912208 srf srf ENSPMEP00000005900 ENSPMEP00000005900 ENSPMEP00000004999 ENSPMEP00000004999 LOC106932859 LOC106932859 LOC106914291 LOC106914291 LOC106930956 LOC106930956 spint1 spint1 LOC106920493 LOC106920493 ENSPMEP00000003807 ENSPMEP00000003807 bmp4 bmp4 fgf7 fgf7 ctsz ctsz spry1 spry1 LOC106911519 LOC106911519 ENSPMEP00000000668 ENSPMEP00000000668
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106927467Suppressor of cytokine signaling 3. (208 aa)
edn1Endothelin 1. (207 aa)
gbx2Gastrulation brain homeobox 2. (342 aa)
plxna4Plexin A4. (1375 aa)
LOC106929094Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (306 aa)
LOC106917549TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
LOC106931238WT1 transcription factor a. (445 aa)
LOC106929752Dystroglycan 1. (892 aa)
LOC106919996Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
LOC106919274Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (184 aa)
LOC106931781MADS-box domain-containing protein. (472 aa)
ppp3r1Uncharacterized protein. (160 aa)
tcf21Transcription factor 21. (175 aa)
ENSPMEP00000029638Suppressor of cytokine signaling 3a. (199 aa)
ilkUncharacterized protein. (452 aa)
il10Interleukin 10. (181 aa)
pkd1Polycystic kidney disease 1a. (4429 aa)
LOC106923514Mothers against decapentaplegic homolog. (503 aa)
LOC106920767HMG box domain-containing protein. (502 aa)
setd2SET domain containing 2, histone lysine methyltransferase. (2576 aa)
timelessTimeless circadian clock. (1250 aa)
ENSPMEP00000026667Uncharacterized protein. (565 aa)
LOC106925627Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (163 aa)
sars1Seryl-tRNA synthetase. (503 aa)
ILKIntegrin linked kinase. (452 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
LOC106903221Androgen receptor beta. (755 aa)
plxna1Sema domain-containing protein. (1948 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1793 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
LOC106915081Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (853 aa)
SMAD4Mothers against decapentaplegic homolog. (510 aa)
lrp6Low density lipoprotein receptor-related protein 6. (1608 aa)
bcl2BCL2 apoptosis regulator b. (229 aa)
tmem59lTransmembrane protein 59-like. (340 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
tmed2Transmembrane p24 trafficking protein 2. (201 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PLXNA2Plexin A2. (1882 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
mks1MKS transition zone complex subunit 1. (492 aa)
fem1bFem-1 homolog b (C. elegans). (627 aa)
LOC106914502Serine peptidase inhibitor, Kunitz type 1 b. (500 aa)
sema3aSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (801 aa)
SOX9SRY-box transcription factor 9. (496 aa)
LOC106907692Plexin_cytopl domain-containing protein. (74 aa)
LOC106927838Uncharacterized protein. (341 aa)
dlg5Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2067 aa)
PRDM1PR/SET domain 1. (615 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
hhipHedgehog interacting protein. (697 aa)
btbd7BTB (POZ) domain containing 7. (1116 aa)
sox10SRY-box transcription factor 10. (499 aa)
LOC106909302Mothers against decapentaplegic homolog. (534 aa)
sox9SRY-box transcription factor 9b. (479 aa)
LOC106920633Sprouty RTK signaling antagonist 2. (347 aa)
LOC106903560Nuclear factor of activated T cells 4. (891 aa)
LOC106920679Uncharacterized protein. (783 aa)
LOC106909474Low density lipoprotein receptor-related protein 5. (1600 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (325 aa)
bmp2Bone morphogenetic protein 2b. (419 aa)
LOC106907870Colony stimulating factor 1b (macrophage). (291 aa)
LOC106925465Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
LOC106920166Bone morphogenetic protein 16. (509 aa)
ENSPMEP00000010756Sema domain-containing protein. (442 aa)
LOC106908804Peptidase S72 domain-containing protein. (907 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (770 aa)
wt1WT1 transcription factor b. (422 aa)
LOC106928804Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (469 aa)
LOC106920283Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (456 aa)
lef1Lymphoid enhancer-binding factor 1. (364 aa)
arUncharacterized protein. (681 aa)
greb1Growth regulating estrogen receptor binding 1. (1998 aa)
LOC106923072PR domain containing 1b, with ZNF domain. (630 aa)
LOC106912208Plexin A3. (1138 aa)
srfSerum response factor b. (601 aa)
ENSPMEP00000005900PR domain containing 1a, with ZNF domain. (817 aa)
ENSPMEP00000004999Musculin (activated B-cell factor-1). (163 aa)
LOC106932859NK3 homeobox 1. (196 aa)
LOC106914291Uncharacterized protein. (437 aa)
LOC106930956Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (362 aa)
spint1Serine peptidase inhibitor, Kunitz type 1 a. (481 aa)
LOC106920493Plexin A2. (1822 aa)
ENSPMEP00000003807Plexin_cytopl domain-containing protein. (47 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)
LOC106911519Uncharacterized protein. (186 aa)
ENSPMEP00000000668Plexin_cytopl domain-containing protein. (161 aa)
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
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