| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aflv_0583 | gerE | Aflv_0583 | Aflv_0584 | Thioesterase superfamily enzyme. | Transcriptional regulator GerE family. | 0.720 |
| Aflv_0583 | racE | Aflv_0583 | Aflv_0585 | Thioesterase superfamily enzyme. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.595 |
| Aflv_0588 | Aflv_0589 | Aflv_0588 | Aflv_0589 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Predicted phosphoesterase. | 0.984 |
| Aflv_0588 | racE | Aflv_0588 | Aflv_0585 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.953 |
| Aflv_0588 | rph | Aflv_0588 | Aflv_0587 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.992 |
| Aflv_0589 | Aflv_0588 | Aflv_0589 | Aflv_0588 | Predicted phosphoesterase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.984 |
| Aflv_0589 | racE | Aflv_0589 | Aflv_0585 | Predicted phosphoesterase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.474 |
| Aflv_0589 | rph | Aflv_0589 | Aflv_0587 | Predicted phosphoesterase. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.826 |
| Aflv_2269 | Aflv_2270 | Aflv_2269 | Aflv_2270 | Metal-dependent hydrolase of the beta-lactamase superfamily III. | Uncharacterized conserved protein. | 0.587 |
| Aflv_2269 | lipM | Aflv_2269 | Aflv_0919 | Metal-dependent hydrolase of the beta-lactamase superfamily III. | Lipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.405 |
| Aflv_2270 | Aflv_2269 | Aflv_2270 | Aflv_2269 | Uncharacterized conserved protein. | Metal-dependent hydrolase of the beta-lactamase superfamily III. | 0.587 |
| Aflv_2499 | lipL | Aflv_2499 | Aflv_2759 | Esterase/lipase. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.720 |
| Aflv_2499 | rnr | Aflv_2499 | Aflv_2498 | Esterase/lipase. | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.886 |
| gerE | Aflv_0583 | Aflv_0584 | Aflv_0583 | Transcriptional regulator GerE family. | Thioesterase superfamily enzyme. | 0.720 |
| gerE | racE | Aflv_0584 | Aflv_0585 | Transcriptional regulator GerE family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.632 |
| lipA | lipL | Aflv_2425 | Aflv_2759 | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.927 |
| lipA | lipM | Aflv_2425 | Aflv_0919 | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Lipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.950 |
| lipL | Aflv_2499 | Aflv_2759 | Aflv_2499 | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | Esterase/lipase. | 0.720 |
| lipL | lipA | Aflv_2759 | Aflv_2425 | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.927 |
| lipL | lipM | Aflv_2759 | Aflv_0919 | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | Lipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.935 |