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hpt hpt guaC guaC deoD deoD deoB deoB deoA deoA deoC deoC EFC57806.1 EFC57806.1 tmk tmk add add tdk tdk amn amn udk udk ade ade cdd cdd EFC56031.1 EFC56031.1 upp upp guaA guaA guaB guaB gpt gpt ppnP ppnP apt apt adk adk EFC55698.1 EFC55698.1 ushA ushA dut dut EFC54739.1 EFC54739.1 EFC54497.1 EFC54497.1 purA purA cpdB cpdB udp udp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hptKEGG: cko:CKO_03242 1.2e-88 hypothetical protein; K00760 hypoxanthine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97. (182 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
deoDKEGG: sew:SeSA_A4824 3.5e-123 deoD; purine nucleoside phosphorylase K03784; Psort location: Cytoplasmic, score: 8.96. (239 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (444 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (283 aa)
EFC57806.1HAD hydrolase, TIGR02254 family; KEGG: ent:Ent638_0533 2.7e-109 nucleotidase K08723; Psort location: Cytoplasmic, score: 8.96. (225 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
addAdenosine deaminase; KEGG: ent:Ent638_1825 9.3e-162 adenosine deaminase K01488; Psort location: Cytoplasmic, score: 8.96; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
tdkThymidine kinase; KEGG: ent:Ent638_2305 3.3e-95 thymidine kinase K00857; Psort location: Cytoplasmic, score: 8.96. (204 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (496 aa)
udkUridine kinase; KEGG: sed:SeD_A2463 4.6e-105 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 8.96. (213 aa)
adeKEGG: kpe:KPK_1614 4.0e-257 putative adenine deaminase; K01486 adenine deaminase; Psort location: Cytoplasmic, score: 8.96. (592 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
EFC56031.1HD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
guaAGMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (539 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (95 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
EFC55698.1Kinase, PfkB family; KEGG: ent:Ent638_0956 7.8e-229 inosine-guanosine kinase K00892. (434 aa)
ushAKEGG: ent:Ent638_0959 6.3e-282 ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor K11751; Psort location: Periplasmic, score: 10.00; Belongs to the 5'-nucleotidase family. (550 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
EFC54739.1HAD hydrolase, family IA, variant 3; KEGG: rso:RSc2880 1.2e-05 gph; phosphoglycolate phosphatase K01091. (227 aa)
EFC54497.1Putative lysine decarboxylase; KEGG: hch:HCH_00651 5.8e-130 Rossmann fold nucleotide-binding protein; K00052 3-isopropylmalate dehydrogenase; Psort location: Cytoplasmic, score: 8.96. (444 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
cpdBKEGG: ent:Ent638_0392 0. cpdB; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; K01119 2',3'-cyclic-nucleotide 2'-phosphodiesterase K08693; Psort location: Periplasmic, score: 10.00; Belongs to the 5'-nucleotidase family. (647 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
Your Current Organism:
Enterobacter cancerogenus
NCBI taxonomy Id: 500639
Other names: E. cancerogenus ATCC 35316, Enterobacter cancerogenus ATCC 35316, Enterobacter cancerogenus str. ATCC 35316, Enterobacter cancerogenus strain ATCC 35316
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