STRINGSTRING
yaaX yaaX yaaA yaaA yaaJ yaaJ can can gloB gloB yahB yahB cynR cynR cynT cynT cynS cynS cynX cynX brnQ brnQ proY proY ybeF ybeF rihA rihA ybhD ybhD ycaN ycaN ghrA ghrA dauA dauA aldA aldA ydcI ydcI yneJ yneJ gloA gloA dmlR dmlR sdaA sdaA hchA hchA mtfA mtfA yeeN yeeN cbl cbl nac nac plaP plaP yeeY yeeY yeeZ yeeZ bcr bcr lrhA lrhA dsdC dsdC dsdX dsdX dsdA dsdA nupC nupC xapR xapR xapB xapB xapA xapA yfeN yfeN yfeR yfeR yfeH yfeH gcvR gcvR hcaR hcaR yfhH yfhH sdaC sdaC sdaB sdaB gcvA gcvA lysR lysR ygfI ygfI nupG nupG sstT sstT yhaO yhaO tdcF tdcF tdcC tdcC tdcB tdcB tdcA tdcA tdcR tdcR yhjC yhjC ghrB ghrB yiaT yiaT yiaU yiaU gltS gltS yihG yihG yijO yijO yjbB yjbB gltP gltP cycA cycA serB serB yhaM yhaM tdcG tdcG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yaaXDUF2502 family putative periplasmic protein; To E.coli YpeC. (98 aa)
yaaAPeroxide resistance protein, lowers intracellular iron; Involved in the cellular response to hydrogen peroxide (H(2)O(2)) stress. During H(2)O(2) stress, prevents oxidative damage to both DNA and proteins by diminishing the amount of unincorporated iron within the cell. (258 aa)
yaaJPutative transporter; Inner membrane transport protein. (476 aa)
canPutative carbonic anhdrase; Belongs to the beta-class carbonic anhydrase family. (220 aa)
gloBHydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli. The two isoenzymes have additive effects and ensure maximal MG degradation. (251 aa)
yahBPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription. (310 aa)
cynRTranscriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. (299 aa)
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate. (219 aa)
cynSCyanate aminohydrolase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. (156 aa)
cynXPutative cyanate transporter; This protein is part of an active transport system that transports exogenous cyanate into E.coli cells; Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. (384 aa)
brnQBranched-chain amino acid transport system 2 carrier protein; Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H(+)-coupled. (439 aa)
proYProline-specific permease; Permease that is involved in the transport across the cytoplasmic membrane of proline; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (457 aa)
ybeFPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa)
rihARibonucleoside hydrolase 1; Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively. (311 aa)
ybhDPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa)
ycaNPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (302 aa)
ghrAGlyoxylate/hydroxypyruvate reductase A; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate. Only D- and L-glycerate are involved in the oxidative activity with NADP. Activity with NAD is very low. (312 aa)
dauAC4-dicarboxylic acid transporter; Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4- dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and/or activity of DctA. May act as a co- sensor of DcuS. (559 aa)
aldAAldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes. (479 aa)
ydcIPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (307 aa)
yneJPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa)
gloAGlyoxalase I, Ni-dependent; Catalyzes the isomerization of the hemithioacetal formed spontaneously from methylglyoxal and glutathione, to S- lactoylglutathione, which is then hydrolyzed by a type II glyoxalase (GloB or GloC). Is involved in methylglyoxal (MG) detoxification (Probable). Involved in resistance to hypochlorous acid (HOCl), which is the active component of household bleach and a powerful antimicrobial during the innate immune response. (135 aa)
dmlRTranscriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. (307 aa)
sdaAL-serine dehydratase 1; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
hchAProtein/nucleic acid deglycase 1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, aspartate aminotransferase, [...] (283 aa)
mtfAAnti-repressor for DgsA(Mlc); Involved in the regulation of ptsG expression by binding and inactivating Mlc; Belongs to the MtfA family. (265 aa)
yeeNUPF0082 family protein; Belongs to the TACO1 family. YeeN subfamily. (238 aa)
cblssuEADCB/tauABCD operon transcriptional activator; May be an accessory regulatory protein within the cys regulon. (316 aa)
nacNitrogen assimilation regulon transcriptional regulator; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity). (305 aa)
plaPPutrescine importer, low affinity; Putrescine importer. Required for induction of type 1 pili- driven surface motility. (452 aa)
yeeYPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (309 aa)
yeeZPutative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process. (274 aa)
bcrBicyclomycin/cysteine/sulfonamide efflux transporter; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs [...] (396 aa)
lrhATranscriptional repressor of flagellar, motility and chemotaxis genes; Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon. (312 aa)
dsdCDsd operon activator; Regulates the expression of the dsdX-dsdA operon. (311 aa)
dsdXD-serine transporter; A D-serine-specific transporter, may function as a H(+) symporter. (445 aa)
dsdAD-serine dehydratase (deaminase); Protein involved in cellular amino acid catabolic process. (442 aa)
nupCNucleoside (except guanosine) transporter; Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force. Transports cytidine, uridine, thymidine, adenosine and inosine. Can also transport xanthosine, but with a very low affinity. (400 aa)
xapRTranscriptional activator of xapAB; Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine. (294 aa)
xapBXanthosine transporter; Uptake of xanthosine. Driven by a proton motive force. Can also transport other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. (418 aa)
xapAPurine nucleoside phosphorylase 2; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This protein can degrade all purine nucleosides including xanthosine, inosine and guanosine, but cannot cleave adenosine, deoxyadenosine or hypoxanthine arabinoside. Has a preference for the neutral over the monoanionic form of xanthosine. (277 aa)
yfeNPutative outer membrane protein; Putative sugar hydrolase; Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family. (254 aa)
yfeRPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (308 aa)
yfeHPutative inorganic ion transporter; Putative cytochrome oxidase; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (332 aa)
gcvRTranscriptional repressor, regulatory protein accessory to GcvA; Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity. (190 aa)
hcaRHca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. (296 aa)
yfhHPutative DNA-binding transcriptional regulator. (282 aa)
sdaCPutative serine transporter; Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity. (429 aa)
sdaBL-serine dehydratase 2; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
gcvAGlycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter; Belongs to the LysR transcriptional regulatory family. (305 aa)
lysRTranscriptional activator of lysA; This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression; Belongs to the LysR transcriptional regulatory family. (311 aa)
ygfIPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (298 aa)
nupGNucleoside transporter; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Can transport uridine, adenosine, inosine, guanosine, thymidine and cytidine. Can also transport xanthosine, but with a very low affinity. Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (418 aa)
sstTSodium:serine/threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). (414 aa)
yhaOPutative transporter; Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
tdcFPutative reactive intermediate deaminase; May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2- ketobutyrate. (129 aa)
tdcCL-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
tdcBL-threonine dehydratase, catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine t [...] (329 aa)
tdcATdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon. Belongs to the LysR transcriptional regulatory family. (312 aa)
tdcRL-threonine dehydratase operon activator protein; Probable trans-acting positive activator for the tdc operon. (72 aa)
yhjCPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (299 aa)
ghrBGlyoxylate/hydroxypyruvate reductase B; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D-gluconate (5KDG), 2- keto-D-gluconate (2KDG) to D-gluconate, and 2-keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D- fructose and L-sorbose. Activity with NAD is very low; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
yiaTPutative outer membrane protein YiaT; Pseudogene, internal sequence remnant. (246 aa)
yiaUPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (324 aa)
gltSGlutamate transporter; Catalyzes the sodium-dependent, binding-protein-independent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (401 aa)
yihGInner membrane protein, inner membrane acyltransferase; Putative endonuclease. (310 aa)
yijOPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (283 aa)
yjbBPutative alpha helix protein. (543 aa)
gltPGlutamate/aspartate:proton symporter; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (437 aa)
cycAD-alanine/D-serine/glycine transporter; Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (470 aa)
serB3-phosphoserine phosphatase; Catalyzes the dephosphorylation of phosphoserine (P-Ser). Also catalyzes the hydrolysis of phosphothreonine (P-Thr). Belongs to the HAD-like hydrolase superfamily. SerB family. (322 aa)
yhaMPutative L-serine dehydratase alpha chain; Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase. (436 aa)
tdcGL-serine dehydratase; Protein involved in cellular amino acid catabolic process. (454 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.