(118 nodes) Signal transduction, and Protein dephosphorylation network (Histoplasma capsulatum H143)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCDG_00505	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. (1584 aa)
	HCDG_00561	Uncharacterized protein. (198 aa)
	HCDG_00634	MAP kinase skh1/pek1; Belongs to the protein kinase superfamily. (344 aa)
	HCDG_00681	Protein kinase domain-containing protein. (362 aa)
	HCDG_00717	Tyrosine phosphatase MSG5. (826 aa)
	HCDG_00801	Uncharacterized protein. (280 aa)
	HCDG_00838	Mitogen-activated protein kinase. (421 aa)
	HCDG_00897	LIM domain-containing protein. (817 aa)
	HCDG_01232	Rho GTPase activator. (835 aa)
	HCDG_01282	Uncharacterized protein. (160 aa)
	HCDG_01332	Polysaccharide deacetylase. (421 aa)
	HCDG_00146	SH3 domain-containing protein. (224 aa)
	HCDG_01362	Small GTPase. (192 aa)
	HCDG_01388	Uncharacterized protein. (327 aa)
	HCDG_00238	Serine/threonine protein kinase. (203 aa)
	HCDG_00311	Serine/threonine protein kinase. (155 aa)
	HCDG_00343	Leucine rich repeat domain-containing protein. (970 aa)
	HCDG_00375	Uncharacterized protein. (471 aa)
	HCDG_00376	Rhodanese domain-containing protein. (370 aa)
	HCDG_01786	Small G-protein GPA2. (256 aa)
	HCDG_02130	Uncharacterized protein. (474 aa)
	HCDG_02319	Uncharacterized protein. (60 aa)
	HCDG_02337	cAMP-dependent protein kinase. (188 aa)
	HCDG_01525	Uncharacterized protein. (317 aa)
	HCDG_01540	Cell division control protein. (1182 aa)
	HCDG_01577	Uncharacterized protein. (252 aa)
	HCDG_01635	Cell morphogenesis protein Sog2. (926 aa)
	HCDG_01657	Rho1 GTPase. (192 aa)
	HCDG_02481	Developmental regulator flbA. (123 aa)
	HCDG_02482	Developmental regulator flbA. (566 aa)
	HCDG_02567	Uncharacterized protein. (173 aa)
	HCDG_02694	GTPase Ras2p. (186 aa)
	HCDG_02838	Uncharacterized protein. (281 aa)
	HCDG_02852	Integral membrane protein. (1175 aa)
	HCDG_03055	G_PROTEIN_RECEP_F2_4 domain-containing protein. (484 aa)
	HCDG_03208	Phosphodiesterase. (865 aa)
	HCDG_03270	Sin3p binding protein. (856 aa)
	HCDG_03306	Rap guanine nucleotide exchange factor 5. (490 aa)
	HCDG_03309	Uncharacterized protein. (181 aa)
	HCDG_03858	ELMO/CED-12 family protein. (720 aa)
	HCDG_03341	Rho guanyl nucleotide exchange factor. (1920 aa)
	HCDG_03353	Rho GTPase activator. (289 aa)
	HCDG_03354	Rho GTPase activator. (207 aa)
	HCDG_03355	Rho-GAP domain-containing protein. (189 aa)
	HCDG_03390	Uncharacterized protein. (249 aa)
	HCDG_03458	Cell division control protein. (1117 aa)
	HCDG_03465	Protein kinase domain-containing protein. (383 aa)
	HCDG_03490	Uncharacterized protein. (332 aa)
	HCDG_03599	Serine/threonine protein kinase Sgk2. (230 aa)
	HCDG_03745	Uncharacterized protein. (96 aa)
	HCDG_04034	Protein kinase domain-containing protein. (336 aa)
	HCDG_04321	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family. (163 aa)
	HCDG_04385	Uncharacterized protein. (100 aa)
	HCDG_04496	Hydrophobin 1. (99 aa)
	HCDG_04511	SH3 and Ded_cyto domain-containing protein; Belongs to the DOCK family. (2124 aa)
	HCDG_04769	Serine/threonine protein kinase. (1323 aa)
	HCDG_04873	Uncharacterized protein. (250 aa)
	HCDG_04956	RAS small monomeric GTPase. (247 aa)
	HCDG_04539	Protein kinase. (396 aa)
	HCDG_04614	Serine/threonine protein kinase Sgk2. (143 aa)
	HCDG_04662	PH domain-containing protein. (983 aa)
	HCDG_05230	Rho1 GDP-GTP exchange protein. (1147 aa)
	HCDG_05262	Small G-protein GPA1. (353 aa)
	HCDG_05295	Chimerin 1. (1205 aa)
	HCDG_05298	Mannosylphosphate transferase. (289 aa)
	HCDG_05386	RNA processing factor 1. (348 aa)
	HCDG_05105	Uncharacterized protein. (276 aa)
	HCDG_05117	Integrase_H2C2 domain-containing protein. (214 aa)
	HCDG_05155	Glycogen synthase kinase; Belongs to the protein kinase superfamily. (291 aa)
	HCDG_05217	Uncharacterized protein. (388 aa)
	HCDG_05485	Peptidylprolyl isomerase. (178 aa)
	HCDG_05562	MAP kinase activator. (595 aa)
	HCDG_06282	Serine/threonine protein kinase. (317 aa)
	HCDG_05902	Uncharacterized protein. (381 aa)
	HCDG_06020	Rho guanyl nucleotide exchange factor. (963 aa)
	HCDG_06124	Uncharacterized protein. (201 aa)
	HCDG_06320	Vacuolar membrane protein. (359 aa)
	HCDG_06416	Adenylate cyclase. (985 aa)
	HCDG_06417	Adenylate cyclase. (509 aa)
	HCDG_06493	CAMK kinase. (640 aa)
	HCDG_06569	Uncharacterized protein. (186 aa)
	HCDG_06570	cAMP-dependent protein kinase type 2. (325 aa)
	HCDG_06704	Protein phosphatase 2C. (611 aa)
	HCDG_06738	Uncharacterized protein. (733 aa)
	HCDG_06834	Small G-beta protein GPB. (298 aa)
	HCDG_06842	PH domain-containing protein. (393 aa)
	HCDG_06866	Hr1 domain-containing protein. (82 aa)
	HCDG_06868	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (766 aa)
	HCDG_07551	GTPase activating protein. (624 aa)
	HCDG_07556	Rac1 GTPase. (188 aa)
	HCDG_07616	Calcium/calmodulin dependent protein kinase. (212 aa)
	HCDG_07623	Rho3 protein. (101 aa)
	HCDG_07624	Uncharacterized protein. (40 aa)
	HCDG_07150	Rho-gdp dissociation inhibitor. (160 aa)
	HCDG_07177	Uncharacterized protein. (212 aa)
	HCDG_07334	TRAF-type zinc finger protein. (474 aa)
	HCDG_07393	Rho3 GTPase. (246 aa)
	HCDG_07636	FYVE domain-containing protein. (286 aa)
	HCDG_07713	Extracellular serine-rich protein. (126 aa)
	HCDG_07774	Protein phosphatase 2c. (675 aa)
	HCDG_07914	cAMP-specific phosphodiesterase. (544 aa)
	HCDG_07922	Protein kinase domain-containing protein. (391 aa)
	HCDG_08243	Calcium/calmodulin dependent protein kinase. (206 aa)
	HCDG_08301	Protein phosphatase 2C. (285 aa)
	HCDG_08302	PPM-type phosphatase domain-containing protein. (104 aa)
	HCDG_08873	Chitin synthase export chaperone. (333 aa)
	HCDG_08917	Uncharacterized protein. (196 aa)
	HCDG_08494	Rho GTPase activator. (1247 aa)
	HCDG_08519	Protein-tyrosine phosphatase. (497 aa)
	HCDG_08605	Uncharacterized protein. (267 aa)
	HCDG_08977	Tetraspanin. (224 aa)
	HCDG_08993	Leupaxin. (570 aa)
	HCDG_09033	MAP kinase Hogp. (252 aa)
	HCDG_09143	RhoGAP domain-containing protein. (1749 aa)
	HCDG_09251	AT DNA binding protein. (323 aa)
	HCDG_09382	Uncharacterized protein. (239 aa)
	HCDG_09425	Calcium/calmodulin-dependent protein kinase. (522 aa)
	HCDG_09481	Small G-protein GPA3. (175 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCDG_00146	HCDG_00238	C6H465	C6H4N7	SH3 domain-containing protein.	Serine/threonine protein kinase.	0.642
HCDG_00146	HCDG_00311	C6H465	C6H4Z0	SH3 domain-containing protein.	Serine/threonine protein kinase.	0.642
HCDG_00146	HCDG_00343	C6H465	C6H522	SH3 domain-containing protein.	Leucine rich repeat domain-containing protein.	0.551
HCDG_00146	HCDG_00375	C6H465	C6H554	SH3 domain-containing protein.	Uncharacterized protein.	0.815
HCDG_00146	HCDG_00376	C6H465	C6H555	SH3 domain-containing protein.	Rhodanese domain-containing protein.	0.800
HCDG_00146	HCDG_00561	C6H465	C6H1H9	SH3 domain-containing protein.	Uncharacterized protein.	0.638
HCDG_00146	HCDG_00681	C6H465	C6H1U9	SH3 domain-containing protein.	Protein kinase domain-containing protein.	0.654
HCDG_00146	HCDG_00801	C6H465	C6H269	SH3 domain-containing protein.	Uncharacterized protein.	0.648
HCDG_00146	HCDG_00838	C6H465	C6H2A6	SH3 domain-containing protein.	Mitogen-activated protein kinase.	0.593
HCDG_00146	HCDG_00897	C6H465	C6H2G5	SH3 domain-containing protein.	LIM domain-containing protein.	0.620
HCDG_00146	HCDG_01332	C6H465	C6H411	SH3 domain-containing protein.	Polysaccharide deacetylase.	0.506
HCDG_00146	HCDG_01362	C6H465	C6H4C3	SH3 domain-containing protein.	Small GTPase.	0.638
HCDG_00146	HCDG_01525	C6H465	C6H7W4	SH3 domain-containing protein.	Uncharacterized protein.	0.764
HCDG_00146	HCDG_01540	C6H465	C6H7X9	SH3 domain-containing protein.	Cell division control protein.	0.956
HCDG_00146	HCDG_01577	C6H465	C6H816	SH3 domain-containing protein.	Uncharacterized protein.	0.638
HCDG_00146	HCDG_01635	C6H465	C6H874	SH3 domain-containing protein.	Cell morphogenesis protein Sog2.	0.584
HCDG_00146	HCDG_01657	C6H465	C6H896	SH3 domain-containing protein.	Rho1 GTPase.	0.638
HCDG_00146	HCDG_02130	C6H465	C6H6S9	SH3 domain-containing protein.	Uncharacterized protein.	0.852
HCDG_00146	HCDG_02319	C6H465	C6H7B8	SH3 domain-containing protein.	Uncharacterized protein.	0.620
HCDG_00146	HCDG_02567	C6H465	C6H8N6	SH3 domain-containing protein.	Uncharacterized protein.	0.693