STRINGSTRING
THITE_2123125 THITE_2123125 THITE_2115326 THITE_2115326 THITE_2047529 THITE_2047529 THITE_2170173 THITE_2170173 THITE_2113671 THITE_2113671 THITE_2115090 THITE_2115090 THITE_2115070 THITE_2115070 THITE_2113448 THITE_2113448 THITE_2113428 THITE_2113428 THITE_2111493 THITE_2111493 THITE_2095566 THITE_2095566 THITE_2111309 THITE_2111309 THITE_2113082 THITE_2113082 THITE_2112983 THITE_2112983 THITE_2114674 THITE_2114674 THITE_17825 THITE_17825 THITE_2114381 THITE_2114381 THITE_2112355 THITE_2112355 THITE_35313 THITE_35313 THITE_2112228 THITE_2112228 THITE_2112219 THITE_2112219 THITE_2112208 THITE_2112208 THITE_2108112 THITE_2108112 THITE_2140658 THITE_2140658 THITE_2106430 THITE_2106430 THITE_2106279 THITE_2106279 THITE_2107958 THITE_2107958 THITE_2111128 THITE_2111128 THITE_2109481 THITE_2109481 THITE_2107922 THITE_2107922 THITE_2141865 THITE_2141865 THITE_2107832 THITE_2107832 THITE_2107682 THITE_2107682 THITE_2107614 THITE_2107614 THITE_2107530 THITE_2107530 THITE_2110682 THITE_2110682 THITE_2107397 THITE_2107397 THITE_2109016 THITE_2109016 THITE_2107259 THITE_2107259 THITE_2107200 THITE_2107200 THITE_2110537 THITE_2110537 THITE_2108999 THITE_2108999 THITE_2028140 THITE_2028140 THITE_2042644 THITE_2042644 THITE_131345 THITE_131345 THITE_2142184 THITE_2142184 THITE_2106865 THITE_2106865 THITE_2108468 THITE_2108468 THITE_2108436 THITE_2108436 THITE_2109968 THITE_2109968 THITE_2073202 THITE_2073202 MCM7 MCM7 THITE_2114040 THITE_2114040 THITE_2115717 THITE_2115717 THITE_2117766 THITE_2117766 THITE_2117872 THITE_2117872 THITE_2116522 THITE_2116522 THITE_160571 THITE_160571 FEN1 FEN1 THITE_2117187 THITE_2117187 THITE_2117218 THITE_2117218 THITE_2117497 THITE_2117497 THITE_2117750 THITE_2117750 THITE_43396 THITE_43396 THITE_72000 THITE_72000 THITE_113492 THITE_113492 THITE_2120214 THITE_2120214 THITE_2120221 THITE_2120221 THITE_2069122 THITE_2069122 THITE_2120339 THITE_2120339 THITE_2120345 THITE_2120345 THITE_2118711 THITE_2118711 THITE_2080045 THITE_2080045 THITE_2119436 THITE_2119436 THITE_2119715 THITE_2119715 SLX4 SLX4 THITE_2122445 THITE_2122445 THITE_2122806 THITE_2122806 THITE_2121145 THITE_2121145 THITE_2121480 THITE_2121480 THITE_2121555 THITE_2121555 THITE_2121819 THITE_2121819 THITE_72944 THITE_72944 THITE_2121878 THITE_2121878 THITE_2124521 THITE_2124521 THITE_2124524 THITE_2124524 THITE_2122999 THITE_2122999 THITE_2082549 THITE_2082549 THITE_2123114 THITE_2123114 THITE_2115327 THITE_2115327 THITE_2124823 THITE_2124823 THITE_2059222 THITE_2059222 THITE_2123185 THITE_2123185 THITE_2124869 THITE_2124869 THITE_2082804 THITE_2082804 THITE_2123847 THITE_2123847 THITE_2123952 THITE_2123952 THITE_2124095 THITE_2124095 THITE_159326 THITE_159326 THITE_2124129 THITE_2124129 THITE_2115480 THITE_2115480
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THITE_2123125Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (912 aa)
THITE_2115326PHD-type domain-containing protein. (563 aa)
THITE_2047529Uncharacterized protein. (239 aa)
THITE_2170173Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
THITE_2113671Vezatin domain-containing protein. (641 aa)
THITE_2115090Uncharacterized protein. (435 aa)
THITE_2115070DNA helicase; Belongs to the MCM family. (911 aa)
THITE_2113448CBFD_NFYB_HMF domain-containing protein. (326 aa)
THITE_2113428SLD3 domain-containing protein. (1047 aa)
THITE_2111493DNA polymerase. (1752 aa)
THITE_2095566CBFD_NFYB_HMF domain-containing protein. (196 aa)
THITE_2111309Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (342 aa)
THITE_2113082Uncharacterized protein. (687 aa)
THITE_2112983Uncharacterized protein. (1251 aa)
THITE_2114674DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (274 aa)
THITE_17825Uncharacterized protein. (124 aa)
THITE_2114381Uncharacterized protein. (167 aa)
THITE_2112355Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (781 aa)
THITE_35313Uncharacterized protein. (783 aa)
THITE_2112228MPN domain-containing protein. (603 aa)
THITE_2112219ORC_WH_C domain-containing protein. (711 aa)
THITE_2112208AAA domain-containing protein. (383 aa)
THITE_2108112DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
THITE_2140658Uncharacterized protein. (211 aa)
THITE_2106430Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
THITE_2106279DNA_pol_E_B domain-containing protein. (817 aa)
THITE_2107958Uncharacterized protein. (163 aa)
THITE_2111128Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (327 aa)
THITE_2109481Uncharacterized protein. (380 aa)
THITE_2107922Uncharacterized protein. (779 aa)
THITE_2141865Uncharacterized protein. (1377 aa)
THITE_2107832Uncharacterized protein. (515 aa)
THITE_2107682DNA polymerase. (1103 aa)
THITE_2107614DNA helicase; Belongs to the MCM family. (719 aa)
THITE_2107530Uncharacterized protein. (612 aa)
THITE_2110682Rtf2 domain-containing protein. (291 aa)
THITE_2107397Uncharacterized protein. (106 aa)
THITE_2109016DNA helicase; Belongs to the MCM family. (836 aa)
THITE_2107259Uncharacterized protein. (536 aa)
THITE_2107200DNA_LIGASE_A3 domain-containing protein. (1043 aa)
THITE_2110537RNase H domain-containing protein. (289 aa)
THITE_2108999MRC1 domain-containing protein. (977 aa)
THITE_2028140Uncharacterized protein. (105 aa)
THITE_2042644PUL domain-containing protein. (587 aa)
THITE_131345Uncharacterized protein. (1447 aa)
THITE_2142184Zf-primase domain-containing protein. (828 aa)
THITE_2106865AAA domain-containing protein. (358 aa)
THITE_2108468Uncharacterized protein. (518 aa)
THITE_2108436Uncharacterized protein. (109 aa)
THITE_2109968Uncharacterized protein. (359 aa)
THITE_2073202Uncharacterized protein. (1032 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (829 aa)
THITE_2114040DNA helicase; Belongs to the MCM family. (1000 aa)
THITE_2115717Uncharacterized protein. (1383 aa)
THITE_2117766DNA ligase. (881 aa)
THITE_2117872Sld5 domain-containing protein. (197 aa)
THITE_2116522Protein kinase domain-containing protein. (494 aa)
THITE_160571UmuC domain-containing protein. (618 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa)
THITE_2117187DNA primase; Belongs to the eukaryotic-type primase small subunit family. (555 aa)
THITE_2117218Uncharacterized protein. (560 aa)
THITE_2117497DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1231 aa)
THITE_2117750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa)
THITE_43396DNA ligase. (749 aa)
THITE_72000FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (570 aa)
THITE_113492Uncharacterized protein. (321 aa)
THITE_2120214DNA polymerase. (1484 aa)
THITE_2120221Uncharacterized protein. (342 aa)
THITE_2069122Uncharacterized protein. (415 aa)
THITE_2120339AAA domain-containing protein. (1278 aa)
THITE_2120345Uncharacterized protein. (837 aa)
THITE_2118711POLAc domain-containing protein. (1198 aa)
THITE_2080045DNA ligase. (1040 aa)
THITE_2119436Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (689 aa)
THITE_2119715DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (667 aa)
SLX4Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (936 aa)
THITE_2122445AAA domain-containing protein. (1020 aa)
THITE_2122806DNA helicase; Belongs to the MCM family. (968 aa)
THITE_2121145WD_REPEATS_REGION domain-containing protein. (733 aa)
THITE_2121480Sld5 domain-containing protein. (216 aa)
THITE_2121555DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (842 aa)
THITE_2121819Cell division control protein; Belongs to the CDC6/cdc18 family. (666 aa)
THITE_72944DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
THITE_2121878Uncharacterized protein. (683 aa)
THITE_2124521AAA domain-containing protein. (352 aa)
THITE_2124524Replication factor C subunit 1. (1058 aa)
THITE_2122999Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (366 aa)
THITE_2082549XPGI domain-containing protein. (815 aa)
THITE_2123114Uncharacterized protein; Belongs to the protein kinase superfamily. (494 aa)
THITE_2115327ORC4_C domain-containing protein. (161 aa)
THITE_2124823AAA domain-containing protein. (389 aa)
THITE_2059222Cnn_1N domain-containing protein. (587 aa)
THITE_2123185Uncharacterized protein. (712 aa)
THITE_2124869Uncharacterized protein. (594 aa)
THITE_2082804Uncharacterized protein. (211 aa)
THITE_2123847WD_REPEATS_REGION domain-containing protein. (898 aa)
THITE_2123952ERCC4 domain-containing protein. (714 aa)
THITE_2124095Uncharacterized protein. (331 aa)
THITE_159326AAA_16 domain-containing protein. (506 aa)
THITE_2124129Uncharacterized protein. (2238 aa)
THITE_2115480Uncharacterized protein. (725 aa)
Your Current Organism:
Thermothielavioides terrestris
NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126
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