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THITE_2123125 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (912 aa) | ||||
THITE_2115326 | PHD-type domain-containing protein. (563 aa) | ||||
THITE_2047529 | Uncharacterized protein. (239 aa) | ||||
THITE_2170173 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) | ||||
THITE_2113671 | Vezatin domain-containing protein. (641 aa) | ||||
THITE_2115090 | Uncharacterized protein. (435 aa) | ||||
THITE_2115070 | DNA helicase; Belongs to the MCM family. (911 aa) | ||||
THITE_2113448 | CBFD_NFYB_HMF domain-containing protein. (326 aa) | ||||
THITE_2113428 | SLD3 domain-containing protein. (1047 aa) | ||||
THITE_2111493 | DNA polymerase. (1752 aa) | ||||
THITE_2095566 | CBFD_NFYB_HMF domain-containing protein. (196 aa) | ||||
THITE_2111309 | Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (342 aa) | ||||
THITE_2113082 | Uncharacterized protein. (687 aa) | ||||
THITE_2112983 | Uncharacterized protein. (1251 aa) | ||||
THITE_2114674 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (274 aa) | ||||
THITE_17825 | Uncharacterized protein. (124 aa) | ||||
THITE_2114381 | Uncharacterized protein. (167 aa) | ||||
THITE_2112355 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (781 aa) | ||||
THITE_35313 | Uncharacterized protein. (783 aa) | ||||
THITE_2112228 | MPN domain-containing protein. (603 aa) | ||||
THITE_2112219 | ORC_WH_C domain-containing protein. (711 aa) | ||||
THITE_2112208 | AAA domain-containing protein. (383 aa) | ||||
THITE_2108112 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa) | ||||
THITE_2140658 | Uncharacterized protein. (211 aa) | ||||
THITE_2106430 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa) | ||||
THITE_2106279 | DNA_pol_E_B domain-containing protein. (817 aa) | ||||
THITE_2107958 | Uncharacterized protein. (163 aa) | ||||
THITE_2111128 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (327 aa) | ||||
THITE_2109481 | Uncharacterized protein. (380 aa) | ||||
THITE_2107922 | Uncharacterized protein. (779 aa) | ||||
THITE_2141865 | Uncharacterized protein. (1377 aa) | ||||
THITE_2107832 | Uncharacterized protein. (515 aa) | ||||
THITE_2107682 | DNA polymerase. (1103 aa) | ||||
THITE_2107614 | DNA helicase; Belongs to the MCM family. (719 aa) | ||||
THITE_2107530 | Uncharacterized protein. (612 aa) | ||||
THITE_2110682 | Rtf2 domain-containing protein. (291 aa) | ||||
THITE_2107397 | Uncharacterized protein. (106 aa) | ||||
THITE_2109016 | DNA helicase; Belongs to the MCM family. (836 aa) | ||||
THITE_2107259 | Uncharacterized protein. (536 aa) | ||||
THITE_2107200 | DNA_LIGASE_A3 domain-containing protein. (1043 aa) | ||||
THITE_2110537 | RNase H domain-containing protein. (289 aa) | ||||
THITE_2108999 | MRC1 domain-containing protein. (977 aa) | ||||
THITE_2028140 | Uncharacterized protein. (105 aa) | ||||
THITE_2042644 | PUL domain-containing protein. (587 aa) | ||||
THITE_131345 | Uncharacterized protein. (1447 aa) | ||||
THITE_2142184 | Zf-primase domain-containing protein. (828 aa) | ||||
THITE_2106865 | AAA domain-containing protein. (358 aa) | ||||
THITE_2108468 | Uncharacterized protein. (518 aa) | ||||
THITE_2108436 | Uncharacterized protein. (109 aa) | ||||
THITE_2109968 | Uncharacterized protein. (359 aa) | ||||
THITE_2073202 | Uncharacterized protein. (1032 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (829 aa) | ||||
THITE_2114040 | DNA helicase; Belongs to the MCM family. (1000 aa) | ||||
THITE_2115717 | Uncharacterized protein. (1383 aa) | ||||
THITE_2117766 | DNA ligase. (881 aa) | ||||
THITE_2117872 | Sld5 domain-containing protein. (197 aa) | ||||
THITE_2116522 | Protein kinase domain-containing protein. (494 aa) | ||||
THITE_160571 | UmuC domain-containing protein. (618 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa) | ||||
THITE_2117187 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (555 aa) | ||||
THITE_2117218 | Uncharacterized protein. (560 aa) | ||||
THITE_2117497 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1231 aa) | ||||
THITE_2117750 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa) | ||||
THITE_43396 | DNA ligase. (749 aa) | ||||
THITE_72000 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (570 aa) | ||||
THITE_113492 | Uncharacterized protein. (321 aa) | ||||
THITE_2120214 | DNA polymerase. (1484 aa) | ||||
THITE_2120221 | Uncharacterized protein. (342 aa) | ||||
THITE_2069122 | Uncharacterized protein. (415 aa) | ||||
THITE_2120339 | AAA domain-containing protein. (1278 aa) | ||||
THITE_2120345 | Uncharacterized protein. (837 aa) | ||||
THITE_2118711 | POLAc domain-containing protein. (1198 aa) | ||||
THITE_2080045 | DNA ligase. (1040 aa) | ||||
THITE_2119436 | Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (689 aa) | ||||
THITE_2119715 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (667 aa) | ||||
SLX4 | Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (936 aa) | ||||
THITE_2122445 | AAA domain-containing protein. (1020 aa) | ||||
THITE_2122806 | DNA helicase; Belongs to the MCM family. (968 aa) | ||||
THITE_2121145 | WD_REPEATS_REGION domain-containing protein. (733 aa) | ||||
THITE_2121480 | Sld5 domain-containing protein. (216 aa) | ||||
THITE_2121555 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (842 aa) | ||||
THITE_2121819 | Cell division control protein; Belongs to the CDC6/cdc18 family. (666 aa) | ||||
THITE_72944 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa) | ||||
THITE_2121878 | Uncharacterized protein. (683 aa) | ||||
THITE_2124521 | AAA domain-containing protein. (352 aa) | ||||
THITE_2124524 | Replication factor C subunit 1. (1058 aa) | ||||
THITE_2122999 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (366 aa) | ||||
THITE_2082549 | XPGI domain-containing protein. (815 aa) | ||||
THITE_2123114 | Uncharacterized protein; Belongs to the protein kinase superfamily. (494 aa) | ||||
THITE_2115327 | ORC4_C domain-containing protein. (161 aa) | ||||
THITE_2124823 | AAA domain-containing protein. (389 aa) | ||||
THITE_2059222 | Cnn_1N domain-containing protein. (587 aa) | ||||
THITE_2123185 | Uncharacterized protein. (712 aa) | ||||
THITE_2124869 | Uncharacterized protein. (594 aa) | ||||
THITE_2082804 | Uncharacterized protein. (211 aa) | ||||
THITE_2123847 | WD_REPEATS_REGION domain-containing protein. (898 aa) | ||||
THITE_2123952 | ERCC4 domain-containing protein. (714 aa) | ||||
THITE_2124095 | Uncharacterized protein. (331 aa) | ||||
THITE_159326 | AAA_16 domain-containing protein. (506 aa) | ||||
THITE_2124129 | Uncharacterized protein. (2238 aa) | ||||
THITE_2115480 | Uncharacterized protein. (725 aa) |