(40 nodes) Butanoate metabolism network (Escherichia coli IAI1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ilvI	Acetolactate synthase III, large subunit; Function experimentally demonstrated in the studied species; enzyme. (574 aa)
	ilvH	Acetolactate synthase III, thiamin-dependent, small subunit; Function experimentally demonstrated in the studied species; enzyme. (163 aa)
	mhpF	acetaldehyde-CoA dehydrogenase II, NAD-binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (316 aa)
	sdhC	Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Function experimentally demonstrated in the studied species; membrane component. (129 aa)
	sdhD	Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
	sdhA	Succinate dehydrogenase, flavoprotein subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
	sdhB	Succinate dehydrogenase, FeS subunit; Function experimentally demonstrated in the studied species; carrier. (238 aa)
	ybiW	Putative glycyl radical cofactor protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (810 aa)
	pflB	Pyruvate formate lyase I; Function experimentally demonstrated in the studied species; enzyme. (760 aa)
	adhE	Fused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
	puuE	GABA aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
	ydbK	Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1174 aa)
	paaF	enoyl-CoA hydratase-isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
	paaH	3-hydroxybutyryl-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (475 aa)
	CAQ98343.1	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (256 aa)
	CAQ98345.1	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (307 aa)
	CAQ98346.1	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (401 aa)
	scoB	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (218 aa)
	scoA	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
	gadB	Glutamate decarboxylase B, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the group II decarboxylase family. (466 aa)
	yneI	Putative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (462 aa)
	ydiF	Short chain acyl-CoA transferase: fused alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (531 aa)
	yeaU	Putative tartrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (361 aa)
	yfcX	Fused enoyl-CoA hydratase and epimerase and isomerase; Function experimentally demonstrated in the studied species; enzyme. (714 aa)
	gabD	Succinate-semialdehyde dehydrogenase I, NADP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (482 aa)
	gabT	4-aminobutyrate aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
	yqeF	Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (393 aa)
	tdcE	Pyruvate formate-lyase 4/2-ketobutyrate formate-lyase; Function experimentally demonstrated in the studied species; enzyme. (764 aa)
	gadA	Glutamate decarboxylase A, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (466 aa)
	ilvN	Acetolactate synthase I, small subunit; Function experimentally demonstrated in the studied species; enzyme. (96 aa)
	ilvB	Acetolactate synthase I, large subunit; Function experimentally demonstrated in the studied species; enzyme. (562 aa)
	ilvG	Acetolactate synthase isozyme II large subunit; Function of strongly homologous gene; enzyme. (548 aa)
	ilvM	Acetolactate synthase II, small subunit; Function experimentally demonstrated in the studied species; enzyme. (87 aa)
	fadB	Fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (729 aa)
	yihU	Putative oxidoreductase with NAD(P)-binding Rossmann-fold domain; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (298 aa)
	pflD	Putative formate acetyltransferase 2 (pyruvate formate lyase II); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (765 aa)
	frdD	Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
	frdC	Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
	frdB	Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier. (244 aa)
	frdA	Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme. (602 aa)

Your Current Organism:

Escherichia coli IAI1

NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAQ98343.1	CAQ98345.1	ECIAI1_1486	ECIAI1_1488	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.696
CAQ98343.1	CAQ98346.1	ECIAI1_1486	ECIAI1_1489	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.641
CAQ98343.1	scoA	ECIAI1_1486	ECIAI1_1491	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.969
CAQ98343.1	scoB	ECIAI1_1486	ECIAI1_1490	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.969
CAQ98345.1	CAQ98343.1	ECIAI1_1488	ECIAI1_1486	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.696
CAQ98345.1	CAQ98346.1	ECIAI1_1488	ECIAI1_1489	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.995
CAQ98345.1	fadB	ECIAI1_1488	ECIAI1_4039	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.935
CAQ98345.1	paaF	ECIAI1_1488	ECIAI1_1393	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	enoyl-CoA hydratase-isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.996
CAQ98345.1	paaH	ECIAI1_1488	ECIAI1_1395	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	3-hydroxybutyryl-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme.	0.923
CAQ98345.1	scoA	ECIAI1_1488	ECIAI1_1491	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.979
CAQ98345.1	scoB	ECIAI1_1488	ECIAI1_1490	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.979
CAQ98345.1	ydbK	ECIAI1_1488	ECIAI1_1377	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.635
CAQ98345.1	yfcX	ECIAI1_1488	ECIAI1_2418	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fused enoyl-CoA hydratase and epimerase and isomerase; Function experimentally demonstrated in the studied species; enzyme.	0.936
CAQ98345.1	yqeF	ECIAI1_1488	ECIAI1_2954	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.981
CAQ98346.1	CAQ98343.1	ECIAI1_1489	ECIAI1_1486	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative D-beta-hydroxybutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.641
CAQ98346.1	CAQ98345.1	ECIAI1_1489	ECIAI1_1488	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative 3-hydroxyacyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.995
CAQ98346.1	adhE	ECIAI1_1489	ECIAI1_1259	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.915
CAQ98346.1	fadB	ECIAI1_1489	ECIAI1_4039	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.996
CAQ98346.1	frdA	ECIAI1_1489	ECIAI1_4391	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit; Function experimentally demonstrated in the studied species; enzyme.	0.830
CAQ98346.1	frdB	ECIAI1_1489	ECIAI1_4390	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Fumarate reductase (anaerobic), Fe-S subunit; Function experimentally demonstrated in the studied species; carrier.	0.844