STRINGSTRING
POLL POLL LIG4 LIG4 IFFO2 IFFO2 DCLRE1B DCLRE1B PNKP PNKP ATM ATM ERCC1 ERCC1 PAXX PAXX ERCC8 ERCC8 PSMD14 PSMD14 POLM POLM POLB POLB XRCC4 XRCC4 APLF APLF PRKDC PRKDC POLA1 POLA1 MLH1 MLH1 SETMAR SETMAR ZBTB7A ZBTB7A IFFO1 IFFO1 RNF8 RNF8 ERCC6 ERCC6 CYREN CYREN TP53BP1 TP53BP1 XRCC5 XRCC5 SMARCAL1 SMARCAL1 HMCES HMCES KDM2A KDM2A NHEJ1 NHEJ1 ERCC4 ERCC4 POLQ POLQ LIG3 LIG3 PRPF19 PRPF19 DNTT DNTT XRCC6 XRCC6 DCLRE1A DCLRE1A ATP23 ATP23 HELQ HELQ UVRAG UVRAG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
LIG4DNA ligase. (911 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (287 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
PAXXPAXX non-homologous end joining factor. (204 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
APLFAprataxin and PNKP like factor. (511 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa)
POLA1DNA polymerase. (1465 aa)
MLH1MutL homolog 1. (756 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (564 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1494 aa)
CYRENCell cycle regulator of NHEJ. (159 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
KDM2ALysine demethylase 2A. (1145 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
POLQDNA polymerase theta. (2729 aa)
LIG3DNA ligase. (1009 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (550 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
HELQHelicase, POLQ like. (1101 aa)
UVRAGUV radiation resistance associated. (699 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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