Your Input: | |||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) | ||||
LIG4 | DNA ligase. (911 aa) | ||||
IFFO2 | Intermediate filament family orphan 2; Belongs to the intermediate filament family. (287 aa) | ||||
DCLRE1B | DNA cross-link repair 1B. (532 aa) | ||||
PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) | ||||
PAXX | PAXX non-homologous end joining factor. (204 aa) | ||||
ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) | ||||
PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) | ||||
POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) | ||||
POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) | ||||
XRCC4 | X-ray repair cross complementing 4. (334 aa) | ||||
APLF | Aprataxin and PNKP like factor. (511 aa) | ||||
PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa) | ||||
POLA1 | DNA polymerase. (1465 aa) | ||||
MLH1 | MutL homolog 1. (756 aa) | ||||
SETMAR | SET domain and mariner transposase fusion gene. (684 aa) | ||||
ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) | ||||
IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (564 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1494 aa) | ||||
CYREN | Cell cycle regulator of NHEJ. (159 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) | ||||
XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) | ||||
SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa) | ||||
HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa) | ||||
KDM2A | Lysine demethylase 2A. (1145 aa) | ||||
NHEJ1 | Non-homologous end joining factor 1. (299 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) | ||||
POLQ | DNA polymerase theta. (2729 aa) | ||||
LIG3 | DNA ligase. (1009 aa) | ||||
PRPF19 | Pre-mRNA processing factor 19. (504 aa) | ||||
DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (550 aa) | ||||
XRCC6 | X-ray repair cross complementing 6. (609 aa) | ||||
DCLRE1A | DNA cross-link repair 1A. (1040 aa) | ||||
ATP23 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa) | ||||
HELQ | Helicase, POLQ like. (1101 aa) | ||||
UVRAG | UV radiation resistance associated. (699 aa) |