node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cps-6 | crn-1 | C41D11.8.1 | Y47G6A.8.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.947 |
cps-6 | crn-2 | C41D11.8.1 | CD4.2.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell death-related nuclease 2. | 0.766 |
cps-6 | crn-3 | C41D11.8.1 | C14A4.4a.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | HRDC domain-containing protein. | 0.783 |
cps-6 | crn-4 | C41D11.8.1 | AH9.2.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. | 0.890 |
cps-6 | crn-5 | C41D11.8.1 | C14A4.5.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | RNase_PH domain-containing protein. | 0.873 |
cps-6 | crn-6 | C41D11.8.1 | K04H4.6b.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family. | 0.824 |
cps-6 | crn-7 | C41D11.8.1 | F09G8.2.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Cell-death-related nuclease 7; Belongs to the DNase II family. | 0.498 |
cps-6 | dcr-1 | C41D11.8.1 | K12H4.8.2 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. | 0.403 |
cps-6 | nuc-1 | C41D11.8.1 | C07B5.5.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. | 0.684 |
cps-6 | wah-1 | C41D11.8.1 | Y56A3A.32a.1 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | Worm AIF (Apoptosis inducing factor) Homolog. | 0.973 |
crn-1 | cps-6 | Y47G6A.8.1 | C41D11.8.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | 0.947 |
crn-1 | crn-2 | Y47G6A.8.1 | CD4.2.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cell death-related nuclease 2. | 0.715 |
crn-1 | crn-3 | Y47G6A.8.1 | C14A4.4a.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | HRDC domain-containing protein. | 0.667 |
crn-1 | crn-4 | Y47G6A.8.1 | AH9.2.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. | 0.902 |
crn-1 | crn-5 | Y47G6A.8.1 | C14A4.5.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RNase_PH domain-containing protein. | 0.903 |
crn-1 | crn-6 | Y47G6A.8.1 | K04H4.6b.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family. | 0.755 |
crn-1 | nuc-1 | Y47G6A.8.1 | C07B5.5.1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. | 0.656 |
crn-2 | cps-6 | CD4.2.1 | C41D11.8.1 | Cell death-related nuclease 2. | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. | 0.766 |
crn-2 | crn-1 | CD4.2.1 | Y47G6A.8.1 | Cell death-related nuclease 2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.715 |
crn-2 | crn-3 | CD4.2.1 | C14A4.4a.1 | Cell death-related nuclease 2. | HRDC domain-containing protein. | 0.463 |