STRINGSTRING
wah-1 wah-1 cps-6 cps-6 crn-5 crn-5 crn-3 crn-3 nuc-1 nuc-1 crn-4 crn-4 crn-7 crn-7 crn-6 crn-6 dcr-1 dcr-1 cyn-13 cyn-13 crn-1 crn-1 crn-2 crn-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wah-1Worm AIF (Apoptosis inducing factor) Homolog. (700 aa)
cps-6Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. (308 aa)
crn-5RNase_PH domain-containing protein. (214 aa)
crn-3HRDC domain-containing protein. (876 aa)
nuc-1Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. (375 aa)
crn-4Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. (298 aa)
crn-7Cell-death-related nuclease 7; Belongs to the DNase II family. (367 aa)
crn-6Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family. (378 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
cyn-13Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. (331 aa)
crn-1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
crn-2Cell death-related nuclease 2. (286 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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