Your Input: | |
| | clec-52 | C-type LECtin. (308 aa) |
| | spl-2 | Sphingosine Phosphate Lyase. (542 aa) |
| | lys-7 | Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa) |
| | pgp-5 | p-GlycoProtein related. (1252 aa) |
| | clc-1 | CLaudin-like in Caenorhabditis. (182 aa) |
| | nasp-1 | SHNi-TPR domain-containing protein. (382 aa) |
| | sma-6 | Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (636 aa) |
| | lgg-1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa) |
| | ilys-1 | Invertebrate LYSozyme. (73 aa) |
| | ilys-2 | Invertebrate-type lysozyme 2; Has bacteriolytic activity against Gram-positive bacteria (By similarity). May play a role in resistance to Gram-positive bacterium S.aureus infection. (139 aa) |
| | ilys-3 | Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (139 aa) |
| | gale-1 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa) |
| | abf-2 | Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811. (85 aa) |
| | C50F4.8 | Uncharacterized protein. (300 aa) |
| | bar-1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (811 aa) |
| | ilys-4 | Invertebrate LYSozyme. (159 aa) |
| | ftn-2 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (170 aa) |
| | hpx-2 | Heme peroxidase 2 heavy chain; Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx. It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans. (718 aa) |
| | clec-7 | C-type LECtin. (417 aa) |
| | ksr-1 | Kinase suppressor of Ras A; Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells. In addition, involved in determining vulval precursor cell fate during vulval induction i [...] (771 aa) |
| | ilys-5 | Invertebrate LYSozyme. (139 aa) |
| | thn-2 | THaumatiN family. (233 aa) |
| | cyp-37B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (509 aa) |
| | plc-1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...] (1898 aa) |
| | clec-264 | C-type LECtin. (386 aa) |
| | irg-5 | CUB_2 domain-containing protein. (343 aa) |
| | sur-2 | Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Functi [...] (1589 aa) |
| | mpk-1 | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa) |
| | F43C11.7 | RING-type domain-containing protein. (295 aa) |
| | clec-78 | C-type LECtin. (3514 aa) |
| | skpo-1 | Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily. (655 aa) |
| | drd-50 | Dietary restriction down regulated. (265 aa) |
| | F53A9.8 | Uncharacterized protein. (87 aa) |
| | bli-3 | Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa) |
| | lin-25 | Protein lin-25; Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. (1139 aa) |
| | lys-4 | LYSozyme. (214 aa) |
| | lys-5 | Lysozyme-like protein 5; Plays a role in resistance to Gram-positive bacteria S.aureus or B.thuringiensis infection. (215 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | clec-172 | C-type lectin domain-containing protein. (170 aa) |
| | atg-16.2 | Autophagic-related protein 16.2; Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Plays a role in the recruitment of lipidated lgg-1 probably to the autophagosome membrane to promote autophagosome formation. Furthermore, association with atg-5 is required for the nucleation of lgg-1 positive autophagosomes. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.1 t [...] (534 aa) |
| | sodh-1 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. (349 aa) |
| | dcr-1 | Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa) |
| | egl-30 | Heterotrimeric G protein alpha subunit. (355 aa) |
| | sek-1 | Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa) |
| | srb-6 | Serpentine receptor class beta-6; Mediates recognition and avoidance of Streptomyces species by detecting dodecanoic acid secreted by the bacteria. Also mediates avoidance of decanoic acid which is not secreted by Streptomyces species but this may represent an additional important avoidance response in the environment; Belongs to the nematode receptor-like protein srb family. (337 aa) |
| | lec-8 | Probable galaptin lec-8. (180 aa) |
| | R08F11.7 | Uncharacterized protein. (773 aa) |
| | daf-16 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa) |
| | spp-1 | Saposin B-type domain-containing protein. (108 aa) |
| | math-38 | MATH (Meprin-associated Traf homology) domain containing. (440 aa) |
| | spp-2 | Saposin B-type domain-containing protein. (104 aa) |
| | spp-3 | Saposin B-type domain-containing protein. (100 aa) |
| | spp-5 | Saposin B-type domain-containing protein. (103 aa) |
| | spp-12 | Saposin B-type domain-containing protein. (106 aa) |
| | dkf-2 | Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (1095 aa) |
| | dbl-1 | TGF_BETA_2 domain-containing protein. (365 aa) |
| | hlh-30 | BHLH domain-containing protein. (524 aa) |
| | clec-218 | C-type LECtin. (389 aa) |
| | ilys-6 | Invertebrate-type lysozyme 6; Has bacteriolytic activity against Gram-positive bacteria. Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (138 aa) |
| | dkf-1 | Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (722 aa) |
| | lys-1 | Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection. (298 aa) |
| | lys-2 | Lysozyme-like protein 2; Involved in resistance to Gram-positive bacteria P.aeruginosa or B.thuringiensis infection; Belongs to the glycosyl hydrolase 25 family. (279 aa) |
| | pmk-1 | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa) |
| | clec-61 | C-type LECtin. (403 aa) |
| | clec-60 | VWFA domain-containing protein. (406 aa) |
| | unc-32 | Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa) |
| | lgg-2 | Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...] (142 aa) |
| | lin-45 | Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (855 aa) |
| | wwp-1 | E3 ubiquitin-protein ligase. (794 aa) |
| | clec-82 | C-type lectin domain-containing protein. (464 aa) |
| | mek-2 | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. (387 aa) |
| | hsf-1 | HSF_DOMAIN domain-containing protein. (671 aa) |
| | clec-71 | C-type lectin domain-containing protein. (467 aa) |
| | clec-70 | C-type lectin domain-containing protein. (466 aa) |
