STRINGSTRING
usip-1 usip-1 ntl-2 ntl-2 ife-3 ife-3 exos-4.1 exos-4.1 dis-3 dis-3 cgh-1 cgh-1 crn-5 crn-5 ntl-9 ntl-9 ntl-4 ntl-4 C53A5.16 C53A5.16 skih-2 skih-2 F02E9.10 F02E9.10 pab-2 pab-2 lsm-5 lsm-5 F31C3.2 F31C3.2 exos-7 exos-7 panl-2 panl-2 lsm-4 lsm-4 F33D11.10 F33D11.10 exos-9 exos-9 lsm-1 lsm-1 exos-8 exos-8 F41G3.6 F41G3.6 F43E2.1 F43E2.1 patr-1 patr-1 F43H9.3 F43H9.3 tag-153 tag-153 F44E5.1 F44E5.1 disl-2 disl-2 pqn-39 pqn-39 dcap-2 dcap-2 let-711 let-711 F57B9.3 F57B9.3 inf-1 inf-1 pup-3 pup-3 exos-3 exos-3 H05C05.1 H05C05.1 mut-2 mut-2 K05C4.4 K05C4.4 K07A1.3 K07A1.3 K07A12.4 K07A12.4 parn-1 parn-1 pup-2 pup-2 cid-1 cid-1 ife-2 ife-2 R07H5.11 R07H5.11 T08B2.4 T08B2.4 gut-2 gut-2 pab-1 pab-1 dcs-1 dcs-1 Y34F4.3 Y34F4.3 Y44E3A.6 Y44E3A.6 ttc-37 ttc-37 exos-1 exos-1 dcap-1 dcap-1 mrpl-46 mrpl-46 ntl-3 ntl-3 ccf-1 ccf-1 parn-2 parn-2 lsm-3 lsm-3 panl-3 panl-3 exos-4.2 exos-4.2 lsm-6 lsm-6 exos-2 exos-2 ntl-11 ntl-11 gld-2 gld-2 ccr-4 ccr-4 lsm-7 lsm-7 ZK616.61 ZK616.61
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
usip-1PAP-associated domain-containing protein. (662 aa)
ntl-2NOT2_3_5 domain-containing protein. (444 aa)
ife-3Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (251 aa)
exos-4.1Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family. (240 aa)
dis-3Probable exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. dis-3 has both 3'-5' exonuclease and endonuclease activities (By similarity). (961 aa)
cgh-1ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (430 aa)
crn-5RNase_PH domain-containing protein. (214 aa)
ntl-9NOT-Like (Yeast CCR4/NOT complex component). (330 aa)
ntl-4NOT-Like (Yeast CCR4/NOT complex component). (798 aa)
C53A5.16Uncharacterized protein. (381 aa)
skih-2SKI (Yeast SuperKIller) Helicase homolog. (1266 aa)
F02E9.10WD_REPEATS_REGION domain-containing protein. (455 aa)
pab-2Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (692 aa)
lsm-5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family. (91 aa)
F31C3.2PAP-associated domain-containing protein. (808 aa)
exos-7RNase_PH domain-containing protein. (312 aa)
panl-2Uncharacterized protein F31E3.4. (1131 aa)
lsm-4Probable U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (123 aa)
F33D11.10Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
exos-9EXOSome (Multiexonuclease complex) component. (434 aa)
lsm-1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa)
exos-8RNase_PH domain-containing protein. (277 aa)
F41G3.6Uncharacterized protein. (296 aa)
F43E2.1Uncharacterized protein. (467 aa)
patr-1Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (833 aa)
F43H9.3NTP_transf_2 domain-containing protein. (413 aa)
tag-153NOT2_3_5 domain-containing protein. (733 aa)
F44E5.1Uncharacterized protein. (78 aa)
disl-2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (848 aa)
pqn-39Prion-like-(Q/N-rich)-domain-bearing protein. (733 aa)
dcap-2mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily. (786 aa)
let-711Not1 domain-containing protein. (2641 aa)
F57B9.3Uncharacterized protein; Belongs to the DEAD box helicase family. (394 aa)
inf-1Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. (402 aa)
pup-3PAP-associated domain-containing protein. (482 aa)
exos-3KH_dom_type_1 domain-containing protein. (226 aa)
H05C05.1Uncharacterized protein. (889 aa)
mut-2NTP_transf_2 domain-containing protein. (441 aa)
K05C4.4Uncharacterized protein. (432 aa)
K07A1.3Peptidase C39 domain-containing protein. (232 aa)
K07A12.4Tr-type G domain-containing protein. (610 aa)
parn-13'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa)
pup-2PAP-associated domain-containing protein. (508 aa)
cid-14Fe-4S ferredoxin-type domain-containing protein. (1425 aa)
ife-2Eukaryotic translation initiation factor 4E-2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (228 aa)
R07H5.11Uncharacterized protein. (123 aa)
T08B2.4Uncharacterized protein. (119 aa)
gut-2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa)
pab-1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (646 aa)
dcs-1m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...] (311 aa)
Y34F4.3PAP-associated domain-containing protein. (121 aa)
Y44E3A.6FHA domain-containing protein. (843 aa)
ttc-37TeTratriCopeptide repeat domain protein related. (1114 aa)
exos-1ECR1_N domain-containing protein. (208 aa)
dcap-1mRNA_decap_C domain-containing protein. (332 aa)
mrpl-46Nudix hydrolase domain-containing protein. (265 aa)
ntl-3NOT2_3_5 domain-containing protein. (701 aa)
ccf-1CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa)
parn-2PARN (Poly(A)-specific RiboNuclease) homolog. (490 aa)
lsm-3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
panl-3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (632 aa)
exos-4.2RNase_PH domain-containing protein. (241 aa)
lsm-6Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
exos-2EXOSome (Multiexonuclease complex) component. (303 aa)
ntl-11NOT-Like (Yeast CCR4/NOT complex component). (640 aa)
gld-2Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa)
ccr-4Endo/exonuclease/phosphatase domain-containing protein. (677 aa)
lsm-7Sm domain-containing protein. (104 aa)
ZK616.61Uncharacterized protein. (340 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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